Handa Naofumi

ハンダナオフミ | Handa Naofumi

Affiliation and department：
Homepage URL (1)： http://www.researchgate.net/profile/Naofumi_Handa/#target-disciplines

Research field (5)： Bacteriology , Molecular biology , Systems genomics , Genomics , Genetics

Research keywords (4)： Homologous recombination , Genome rearrangement , Self and non-self recognitandion , DNA-Protein interaction

Research theme for competitive and other funds (11)：

2010 - 2011 天然変性部位がDNAの分解と組換えの切り替えを行う酵素の反応機構
2010 - 2011 自己DNA識別修復酵素の自己DNAシグナル配列認識の分子機構
2009 - 2010 ゲノムの高レベル進化速度に寄与する相同組換えの分子機構
2009 - 2010 無害な細菌が病原性遺伝子を獲得して病原細菌になることを防ぐ機構
2008 - 2009 ゲノムに潜む全く新しい構造と機能をもつDNaseファミリーの探索と解析

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Papers (39)：

Huan Chen, Roberto A. Donnianni, Naofumi Handa, Sarah K. Deng, Julyun Oh, Leonid A. Timashev, Stephen C. Kowalczykowski, Lorraine S. Symington. Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015. 112. 15. E1880-E1887
HANDA Naofumi. MCM8-9 complex promotes resection of double-strand break ends by Mre11-Rad50-Nbs1 complex. Nature Communications. 2015. 6. 7744
Yuen-Ling Chan, M. Scott Brown, Daoming Qin, Naofumi Handa, Douglas K. Bishop. The Third Exon of the Budding Yeast Meiotic Recombination Gene HOP2 Is Required for Calcium-dependent and Recombinase Dmc1-specific Stimulation of Homologous Strand Assimilation. JOURNAL OF BIOLOGICAL CHEMISTRY. 2014. 289. 26. 18076-18086
Liang Yang, Naofumi Handa, Bian Liu, Mark S. Dillingham, Dale B. Wigley, Stephen C. Kowalczykowski. Alteration of chi recognition by RecBCD reveals a regulated molecular latch and suggests a channel-bypass mechanism for biological control. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012. 109. 23. 8907-8912
Naofumi Handa, Liang Yang, Mark S. Dillingham, Ichizo Kobayashi, Dale B. Wigley, Stephen C. Kowalczykowski. Molecular determinants responsible for recognition of the single-stranded DNA regulatory sequence, chi, by RecBCD enzyme. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012. 109. 23. 8901-8906

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Books (10)：

相同組換え初期反応に重要なリセクション
日本生化学会 2010
Double-strand Breaks and their Consequences in Bacteria.
In Encyclopedia of Life Sciences, A21652, Nature Publishing Group, Macmillan Reference Limited, London 2009
組換え酵素
東京化学同人 2007
RecBCD酵素の精製法
朝倉書店 2006
ゲノムを維持する組換え酵素の一分子生化学
共立出版 2005

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Professional career (1)：

博士(医学) (東京大学)

Work history (2)：

2011/04 - University of California, Davis
2004/10 - 2011/03 University of Tokyo Assistant Professor

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