Rchr
J-GLOBAL ID：200901089585244561
Update date: Jan. 30, 2024
Nishiya Naoyuki
ニシヤ ナオユキ | Nishiya Naoyuki
Affiliation and department：
Job title：
Professor
Research field (3)：
Pharmaceuticals - chemistry and drug development
, Pharmacology
, Pharmaceuticals - health and biochemistry
Research keywords (5)：
ケミカルバイオロジー
, シグナル伝達
, 細胞接着
, Signal transduction
, Cell adhesion
Research theme for competitive and other funds (21)：
- 2021 - 2024 Development of a new macrolide derivative targeting mTORC
- 2019 - 2022 Development of A- and F-ring-modified lamellarin type inhibitors effective for C797S mutated EGFR
- 2016 - 2018 Approach of production of dental epithelial cells from periodontal ligament mesenchymal cells for tooth regeneration
- 2014 - 2017 Development of EGFR-Tyrosine Kinase Inhibitors Effective for Non-Small Cell Lung Cancer Resistant to Gefitinib
- 2013 - 2015 非プロテアソーム系β-catenin分解を誘導する化合物群の分子標的基盤研究
- 2011 - 2013 Study of inhibitors and characterization of naturally occurring spheroids from monolayer culture
- 2010 - 2012 脊椎動物ケミカルジェネティクスによるWnt経路阻害剤の作用機構解
- 2008 - 2009 がん抑制遺伝子産物TSLC1による膜輸送制御とその細胞増殖抑制への意義の解析
- 2006 - 2007 反発性ガイド分子受容体の同定と機能解析
- 2001 - 2003 Redox regulation of cell adhesion signals
- 2001 - 2002 integrinの細胞増殖制御におけるHic-5の機能
- 2001 - 2001 細胞老化関連遺伝子を標的とした新規抗がん剤の探索
- 2001 - 2001 細胞接着斑蛋白質Hic-5によるがん細胞形質の調節機構
- 1999 - 2001 Regulation of adhesion signals by a focal adhesion protein, Hie5.
- 2000 - 2000 増殖制御遺伝子エンハンサーを用いた抗がん剤の探索
- 2000 - 2000 細胞接着斑蛋白質Hic-5によるがん細胞形質の調節機構
- 1999 - 2000 新規細胞接着斑蛋白質HIC-5によるマクロファージ機能の制御機構
- 1998 - 2000 ANALYSIS OF CYTOPLASMIC FACTORS THAT PARTICIPATE IN GROWTH ARREST INDUCED BY OXIDATIVE STRESS
- 1999 - 1999 細胞接着斑蛋白質Hic-5の細胞老化、がん化における役割
- Development of an anti-cancer drug screening system in zebrafish
- Identification of repulsive guidance receptors and analysis of their functions
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Papers (38)：
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Honami Yonezawa, Akari Ikeda, Ryo Takahashi, Haruka Endo, Yasuyo Sugawara, Mikako Goto, Mirute Kanno, Sosuke Ogawa, Karin Nakamura, Haruki Ujiie, et al. Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases. iScience. 2022. 25. 3. 103912-103912
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Naoyuki Nishiya, Honami Yonezawa. Domestication of chemicals attacking metazoan embryogenesis: identification of safe natural products modifying developmental signaling pathways in human. The Journal of Antibiotics. 2021. 74. 10. 651-659
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HARUKI UJIIE, SATORU NIHEI, NAOYUKI NISHIYA, SHINPEI GOTO, YOSHIKO ASAKURA, SHOKO MIURA, DAISHI HIRAI, MIKIYA ENDO, TATSUO OYAKE, SHIGEKI ITO, et al. Switching from Intravenous to Oral Tacrolimus Reduces its Blood Concentration in Paediatric Cancer Patients. Anticancer Research. 2021. 41. 5. 2591-2596
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Tsutomu Fukuda, Mizuho Anzai, Akane Nakahara, Kentaro Yamashita, Kazuaki Matsukura, Fumito Ishibashi, Yusuke Oku, Naoyuki Nishiya, Yoshimasa Uehara, Masatomo Iwao. Synthesis and evaluation of azalamellarin N and its A-ring-modified analogues as non-covalent inhibitors of the EGFR T790M/L858R mutant. Bioorganic and Medicinal Chemistry. 2021. 34
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Naoyuki Nishiya, Yusuke Oku, Chie Ishikawa, Tsutomu Fukuda, Shingo Dan, Tetsuo Mashima, Masaru Ushijima, Yoko Furukawa, Yuka Sasaki, Keishi Otsu, et al. Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor. Cancer Science. 2021. 112. 5. 1963-1974
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MISC (7)：
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西谷直之, 河野富一, 上原至雅. ゼブラフィッシュ胚を用いたWnt/β-catenin経路ケミカルサプレッサーの探索. 食品薬学シンポジウム講演要旨集. 2013. 5th
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Christopher A. Jones, Nyall R. London, Haoyu Chen, Kye Won Park, Dominique Sauvaget, Rebecca A. Stockton, Joshua D. Wythe, Wonhee Suh, Frederic Larrieu-Lahargue, Yoh-suke Mukouyama, et al. Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability (vol 14, pg 448, 2008). NATURE MEDICINE. 2008. 14. 5. 585-585
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Qisheng Zhang, Michael B. Major, Shinichi Takanashi, Nathan D. Camp, Naoyuki Nishiya, Eric C. Peters, Mark H. Ginsberg, Xiaoying Jian, Paul A. Randazzo, Peter G. Schultz, et al. Small-molecule synergist of the Wnt/beta-catenin signaling pathway (vol 104, pg 7444, 2007). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007. 104. 30. 12581-12581
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N Nishiya. alpha 4 integrins control front-rear polarity during cell migration. SEIKAGAKU. 2006. 78. 4. 334-337
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CC Feral, N Nishiya, CA Fenczik, H Stuhlmann, M Slepak, MH Ginsberg. CD98hc (SL3A2) mediates integron signaling and tumorigenesis. MOLECULAR BIOLOGY OF THE CELL. 2004. 15. 4A-4A
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Patents (1)：
Books (3)：
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薬系薬理学書
南江堂 2018
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化学療法学-病原微生物・がんと戦う-
南江堂 2009
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がん分子標的治療研究実践マニュアル、日本がん分子標的治療学会編
金芳堂 2009
Lectures and oral presentations (11)：
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ゼブラフィッシュ表現型を利用した化合物スクリーニングと毒性評価
(日本学術振興会 アカデミアとインダストリーをつなぐ委員会 2019)
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トポイソメラーゼ阻害剤ラメラリンの標的指向性変換による薬剤耐性EGFR阻害剤の創出
(日本がん分子標的治療学会 第14回TRワークショップ「低分子抗がん剤開発最前線~アカデミアの夢、企業の現実」 2019)
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Chemical suppressors of the Wnt/β-catenin signaling pathway and their molecular targets
(2018 The 6th Tripartite Conference on Tooth and Bone in Development & Regeneration, Hong Kong 2018)
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Identifying chemical suppressors of the Wnt/β-catenin signaling pathway.
(Yonsei Biomedical Dialogue 2018 2018)
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ゼブラフィッシュを用いたケミカルサプレッサーの探索と毒性評価
(平成28年度文部科学省新学術領域研究学術研究支援基盤形成 先端モデル動物支援プラットフォーム 成果発表会 2017)
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Professional career (1)：
Work history (8)：
- 2017/07 - 現在 Iwate Medical University School of Pharmacy Professor
- 2017/01 - 2017/06 Iwate Medical University School of Pharmacy Associate Professor
- 2007/10 - 2016/12 Iwate Medical University School of Pharmacy
- 2006 - 2007 (独)理化学研究所 脳科学総合研究センター 基礎科学特別研究員
- 2006 - 2007 University of California, San Diego
- 2004 - 2006 University of California, San Diego
- 2002 - 2004 スクリップス研究所(カリフォルニア州ラホヤ) 博士研究員
- 1996 - 2002 昭和大学・薬学部 助手
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Association Membership(s) (7)：
JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, The American Society for Cell Biology
, がん分子標的治療研究会
, 日本薬学会
, 日本分子生物学会
, 日本細胞生物学会
, 日本癌学会
