Rchr
J-GLOBAL ID:200901089732732712
Update date: Feb. 01, 2024
Fujimoto Nariaki
フジモト ナリアキ | Fujimoto Nariaki
Affiliation and department:
Research field (3):
Environmental effects of chemicals
, Environmental effects of radiation
, Urology
Research keywords (7):
Biological effects of exposure to radioactive particles
, Thyroid tumor; childhood irradiation; animal models
, thyroid hormone; hypothalamus-pituitary-thyroid axis; rat models
, Estrogen
, EDCs
, Pituitary
, androgen; rat prostate; mouse prostate; prostate cancer
Research theme for competitive and other funds (26):
- 2020 - 2023 小児期放射線被曝による甲状腺機能への影響と障害メカニズムの解明
- 2019 - 2023 Biological effects of radioactive MnO2 particles
- 2019 - 2023 Radiation exposure and health effects of the residents around the former Soviet Union nuclear test site in Kazakhstan -A new perspective: radioactive microparticles-
- 2016 - 2019 Influence of chemicals used in consumer products on endocrine-system via activation of nuclear receptors
- 2014 - 2018 Study of the radiation fallout around the former Soviet Union Semipalatinsk nuclear test site - Dosimetry and health effects -
- 2013 - 2015 Estimation of target proteins of hydroxylated PCB and brominated flame retardants for thyroid hormone disruption and the influence by radiation
- 2011 - 2013 Risk assessment of chemicals using chimeric mice with humanized liver
- 2011 - 2013 Quantitative analysis of neonatal exposure to thyroid hormone disrupting chemicals
- 2010 - 2012 Determination of targets for thyroid hormone disruption by brominated flame retardants
- 2009 - 2011 Clarification of the genes involved in the hyperlipidemia and the application to the preventive medicine
- 2008 - 2010 Effects of neonatal exposure to thyroid hormone disrupting chemicals in rats
- 2006 - 2007 Formation of Hydroxylated Metabolites Responsible for the Toxicity of Brominated Flame Retardants and Thyroid Hormone Disrupting Action
- 2007 - 高感受性集団に於ける化学物質の有害性発現メカニズムの解明及び評価手法開発にかかる総合研究
- 2007 - 化学物質による肝肥大誘導機序の解析を基盤とした肝発がんリスク評価系の構築
- 2005 - 2006 Effects of low-dose endocrine disruptors on neonatal prostatic development
- 2004 - 2005 Thyroid hormone-disrupting activity of brominated retardants and hydroxylated PCBs
- 2004 - 内分泌かく乱物質の胎児新生児暴露によるリスク予測に関する総合研究
- 2002 - 2003 エストロゲン受容体プロモーター遺伝子導入/改変動物による内分泌攪乱物質作用の解析
- 2001 - 2002 Metabolic activation of endocrine-disruptors in animal body
- 2001 - 2002 Effect of Dioxin and Endocrine disrupters on Adrenal Hormone
- 2001 - 2001 ラット前立腺モデルによる内分泌攪乱物質のエストロゲン受容体発現への作用解析
- 2001 - 内分泌かく乱物質の生体影響に関する研究特に低用量効果、複合効果、作用機構について
- 1998 - 1999 Mechanisms of hormone dependent growth of cancer : A pituitary model
- 1996 - 1998 Construction of mouse embryonic stem cells for the detection of gene mutation
- 1998 - 内分泌かく乱物質のヒトの健康への影響のメカニズム等に関する調査研究
- 1996 - 胃の腸上皮化生の遺伝子異常とそのがん化
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Papers (126):
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Valeriy Stepanenko, Andrey Kaprin, Sergey Ivanov, Peter Shegay, Viktoria Bogacheva, Hitoshi Sato, Kazuko Shichijo, Shin Toyoda, Noriyuki Kawano, Megu Ohtaki, et al. Microdistribution of internal radiation dose in biological tissues exposed to 56Mn dioxide microparticles. Journal of radiation research. 2022. 63. Supplement_1. i21-i25
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Valeriy Stepanenko, Andrey Kaprin, Sergey Ivanov, Peter Shegay, Hitoshi Sato, Shin Toyoda, Noriyuki Kawano, Nariaki Fujimoto, Satoru Endo, Viktoria Bogacheva, et al. Estimation of 'dose-depth' profile in the surface layers of a quartz-containing tile from the former Hiroshima University building indicates the possible presence of beta-irradiation from residual radioactivity after A-bombing. Journal of radiation research. 2022. 63. Supplement_1. i54-i60
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Valeriy Stepanenko, Hitoshi Sato, Nariaki Fujimoto, Kazuko Shichijo, Shin Toyoda, Noriyuki Kawano, Satoru Endo, Andrey Kaprin, Sergey Ivanov, Peter Shegay, et al. External dose estimates of laboratory rats and mice during exposure to dispersed neutron-activated 56Mn powder. Journal of radiation research. 2022. 63. Supplement_1. i16-i20
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Keiko Otani, Megu Ohtaki, Nariaki Fujimoto, Darkhan Uzbekov, Ynkar Kairkhanova, Aisulu Saimova, Nailya Chaizhunusova, Dariya Habdarbaeva, Almas Azhimkhanov, Kassym Zhumadilov, et al. Effects of internal exposure to neutron-activated 56MnO2 powder on locomotor activity in rats. Journal of radiation research. 2022. 63. Supplement_1. i38-i44
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Fujimoto, Nariaki, Matsuu-Matsuyama, Mutsumi, Nakashima, Masahiro. Single neonatal irradiation induces long-term gene expression changes in the thyroid gland, which may be involved in the tumorigenesis. SCIENTIFIC REPORTS. 2021. 11. 1. 23620-23620
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MISC (17):
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藤本 成明, 松山 睦美, 中島 正洋. ラット新生仔期甲状腺への放射線被曝で誘発される甲状腺機能不全. 日本内分泌学会雑誌. 2019. 95. 1. 449-449
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藤本 成明, 松山 睦美, 中島 正洋. 新生仔期での甲状腺被曝で特異的に誘発される甲状腺病変. 日本毒性病理学会講演要旨集. 2019. 35回. 54-54
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佐能正剛, 中村直樹, 鈴木賢一, 柏木啓子, 花田秀樹, 山本卓, 新海正, 杉原数美, 藤本成明, 北村繁幸, et al. 環境化学物質におけるカエル甲状腺ホルモン作用のアゴニストおよびアンタゴニスト活性. 衛生薬学・環境トキシコロジー講演要旨集. 2014. 2014. 189
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佐能正剛, 柏木啓子, 花田秀樹, 松原加奈, 川畑公平, 中村直樹, 鈴木賢一, 山本卓, 新海正, 藤本成明, et al. 甲状腺ホルモン様化学物質アミオダロン曝露によるカエルの変態に対する影響. 日本内分泌かく乱化学物質学会研究発表会要旨集. 2012. 15th. 107
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佐能正剛, 柏木啓子, 花田秀樹, 松原加奈, 川畑公平, 新海正, 山本卓, 鈴木賢一, 藤本成明, 杉原数美, et al. 甲状腺ホルモン様物質のアフリカツメガエルの自然変態に対する影響評価. 日本内分泌かく乱化学物質学会研究発表会要旨集. 2011. 14th. 91
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Lectures and oral presentations (19):
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Single neonatal irradiation induces long-term morphological and gene expression changes in the thyroid of rats - a possible mechanism of thyroid carcinogenesis by childhood radiation
(Modern Perspectives for Biomedical Sciences 2022)
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Gene expression alternation by neonatal irradiation in rats II
(The 94th annual congress of the Japan Endocrine Society 2022)
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Gene expression alternation by neonatal irradiation in rats
(The 94th annual congress of the Japan Endocrine Society 2022)
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Changes in morphology and gene expressions of neonatally X-irradiated thyroid gland in rats
(22nd European Congress of Endocrinology 2020)
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Changes in gene expression in the lung and the testis of rats exposed to 56MnO2 particles
(The 23rd Hiroshima International Symposium - International Research Meeting for Studies of Biological Effects of Radioactive Dust in Kazakh, Russia & Japan 2020)
more...
Education (2):
- 1988 - 1992 Hiroshima University Graduate School, Division of Medical Sciences Pathlogy
- 1978 - 1982 Hiroshima University Faculty of Science
Professional career (1):
- Ph.D. (Hiroshima University)
Committee career (3):
- 2018/04 - 2024/03 Food Safety Commission of Japan, Cabinet Office Commission member / Food Safety Commission of Japan
- 2016/04 - 2018/03 Food Safety Commission of Japan, Cabinet Office Expert advisor / Food Safety Commission of Japan
- 2005/04 - 2016/03 Food Safety Commission of Japan, Cabinet Office commission member / Food Safety Commission of Japan
Awards (3):
- 2022/05/26 - Semey Medical University Cooperative Research Award of Semey Medical University
- 2013 - Best Poster Award, ISPROF 2013
- 2003 - Best Paper Award 2003 in Journal of Health Science
Association Membership(s) (5):
The Japan Society of Endocrine Disrupters Research
, Japanese Society of Toxicologic Pathology
, Japan Hormonal Steroid Society
, The European Society of Endocrinology
, The Japan Endocrine Society
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