Rchr

J-GLOBAL ID：200901089960462598 Update date: Apr. 17, 2024

Matsuura Yoshiharu

マツウラヨシハル | Matsuura Yoshiharu

Affiliation and department：
Job title： Professor

Research field (3)： Virology , Veterinary medicine , Conservation science (plants)

Research theme for competitive and other funds (52)：

2020 - 2025 ウイルス-人体相互作用ネットワークの理解と制御
2022 - 2025 光コムの医光融合研究に立脚した新興・再興ウイルスの超高感度・迅速検出
2016 - 2023 「ネオウイルス学」の国際活動支援
2021 - 2022 ネオウイルス学:生命の源流から超個体、そしてエコ・スフィアーへ
2019 - 2022 Significance of interaction between SPP and HCV core protein on viral life cycle.

2020 - 2021 Urgent research on COVID-19 utilizing infectious disease research stations in Asia

2016 - 2021 Analysis of host and viral factors involved in flavivirus symbiosis and evolution

2016 - 2021 Neo-virology: the raison d'etre of viruses

2020 - ウイルス-人体相互作用ネットワークの理解と制御

2016 - 2018 Development of viral oncolytic agent using mammalian orthoreovirus with improved infectivity

2015 - 2018 Characterization of SPP involved in pathogenesis of HCV

2015 - 2017 C型肝炎ウイルスの組織親和性の解析

2013 - 2016 Development of replication-selective oncolytic viral vector using modified mammalian orthoreovirus

2013 - 2015 C型肝炎ウイルスの組織親和性の解析

2012 - 2015 Analysis of propagation mechanisms of hepatitis C virus and establishment of novel permissive cell lines

2011 - 2014 Treatment strategies of recurrent hepatitis C after liver transplantation based on IL28B singlencleotide polymorphism.

2009 - 2011 Analysis of infection mechanisms of hepatitis C virus and establishment of the indicator cell lines for viral infection

2009 - 2010 C型肝炎ウイルスの成熟および複製に関与する宿主因子の解析

2007 - 2008 Analysis of host factors involved in the infection and replication of hepatitis C virus

2007 - 2008 フラビウイルスコア蛋白質の核内移行と病原性発現

2004 - 2005 Study on molecular mechanisms of hepatitis C virus infection.

2003 - 2005 Study on infection and maturation mechanisms of hepatitis C virus and its host response.

2003 - 2003 RNAウイルス研究の新展開

2003 - 2003 C型肝炎ウイルスの感染初期過程の分子機構

2002 - 2002 C型肝炎ウイルスの感染初期過程の分子機構

2001 - 2002 ゲノム構成要素としての転移因子の組み換え機構解析のためのバキュロウイルスの利用

2000 - 2002 Study on infection mechanisms of hepatitis C virus

2001 - 2001 C型肝炎ウイルスの感染初期過程の分子機構

2000 - 2001 DEVELOPMENT OF THERAPY FOR HEPATITIS C USING PROTEIN TRANSDUCTION METHOD

1999 - 2000 Identification of Neutralization Epitope of Hepatitis C Virus Using Chimpanzees Inoculated with Transcribed RNA

1998 - 2000 Study on the structure and function of viral proteins using artificial particles of human rotavirus

1999 - 1999 RNAウイルス研究の最前線

1998 - 1998 RNAウイルス研究の新展開

1997 - 1998 Studies on proliferating mechanism of hepatitis C virus using cultured human liver cell lines by radialflowtype-bioreactor

1996 - 1997 Genetic analysis of wild polioviruses and its ecology

1995 - 1997 Cellular and molecular immunology of an emerging zoonosis, Babesia microti-infection.

1995 - 1996 Study on maturation and replication mechanisms of Pestivirus and hepatitis C virus

1994 - 1996 Study on generation of glycoprotein by recombinant technology.

1994 - 1996 STUDIES ON IFN INHIBITORS ACTING IN HEPATIC CELLS

1993 - 1994 MOLECULAR CLONING AND EXPRESSION OF MACAQUE MONKEY CD4 GENES ; FOR ESTABLISHMENT OF AIDS ANIMAL MODELS.

1992 - 1994 Development of a new PDT vaccine in a single molecule

1991 - 1992 CD4 and CD8 Molecules of Non-human Primates; Molecular Cloning and Their Roles in SIV Infection

1990 - 1991 Studies of the ecology and pathogenicity of Newcastle disease virus.

1989 - 1991 Development of flavivirus vaccine including Japanese encephalitis virus by recombinant DNA technologies

1990 - 1990 C型肝炎ウイルスの遺伝子発現と肝炎・肝癌発症

1987 - 1989 Epidemiological study on Lymphocytic choriomeningitis virus in wild rodents of Japan

新しいC型肝炎治療薬の開発

ウイルスベクターの開発

C型肝炎ウイルスの分子生物学的研究

Development of new therapeutics for hepatitis C.

Development of Viral Vectors

Molecular Biology of Hepatitis C Virus

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Papers (420)：

Shohei Minami, Tomohiro Kotaki, Yusuke Sakai, Shinya Okamura, Shiho Torii, Chikako Ono, Daisuke Motooka, Rina Hamajima, Ryotaro Nouda, Jeffery A Nurdin, et al. Vero cell-adapted SARS-CoV-2 strain shows increased viral growth through furin-mediated efficient spike cleavage. Microbiology spectrum. 2024. e0285923
Rae Maeda, Natsumi Seki, Yoshifumi Uwamino, Masatoshi Wakui, Yu Nakagama, Yasutoshi Kido, Miwa Sasai, Shu Taira, Naoya Toriu, Masahiro Yamamoto, et al. Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19. Nature communications. 2023. 14. 1. 8469-8469
Tina Lusiany, Tohru Terada, Jun-Ichi Kishikawa, Mika Hirose, David Virya Chen, Fuminori Sugihara, Hendra Saputra Ismanto, Floris J van Eerden, Songling Li, Takayuki Kato, et al. Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies. Viruses. 2023. 15. 12
Atsushi Kawai, Nagisa Tokunoh, Eigo Kawahara, Shigeyuki Tamiya, Shinya Okamura, Chikako Ono, Jessica Anindita, Hiroki Tanaka, Hidetaka Akita, Sho Yamasaki, et al. Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses. The Journal of clinical investigation. 2023. 133. 23
Kentaro Uemura, Haruaki Nobori, Akihiko Sato, Shinsuke Toba, Shinji Kusakabe, Michihito Sasaki, Koshiro Tabata, Keita Matsuno, Naoyoshi Maeda, Shiori Ito, et al. 2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 42. e2304139120

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MISC (84)：

Sujin Kang, Toshio Tanaka, Hitomi Inoue, Chikako Ono, Shoji Hashimoto, Yoshiyuki Kioi, Hisatake Matsumoto, Hiroshi Matsuura, Tsunehiro Matsubara, Kentaro Shimizu, et al. COVID-19 induces lower extent of cytokines, but damages vascular endothelium by IL-6 signaling. Proceedings of the National Academy of Sciences of the United States of America. 2021. 118. 21
Asuka Sato, Chikako Ono, Tomokazu Tamura, Hiroyuki Mori, Takuma Izumi, Shiho Torii, Yuzy Fauzyah, Takuya Yamamoto, Yuhei Morioka, Daisuke Okuzaki, et al. Rimonabant suppresses RNA transcription of hepatitis B virus by inhibiting hepatocyte nuclear factor 4α. Microbiology and Immunology. 2020. 64. 5. 345-355
泉琢磨, 坂田一仁, 奥崎大介, 井口昭一, 田村友和, 元岡大祐, 中村昇太, 小野慎子, 下川雅弘, 松浦善治, et al. 肝臓移植レシピエントにおけるペギウイルス感染の特徴. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2019. 67th
Virology for hepatitis C. 2017. 262. 14. 1363-1368
Toru Okamoto, Tatsuya Suzuki, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Yoshiharu Matsuura. Regulation of apoptosis during flavivirus infection. Viruses. 2017. 9. 9

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Patents (4)：

C型肝炎に伴う疾患の予防及び/又は治療薬のスクリーニング方法、C型肝炎に伴う疾患の予防及び/又は治療薬
C型肝炎ウイルスの複製に関与する新規宿主因子の同定
抗HCV剤を同定するためのスクリーニング方法
バキュロウイルスベクター、該バキュロウイルスベクターの製造方法及び該バキュロウイルスベクターを用いた遺伝子導入方法

Books (2)：

Structure-based study of viral replication.
World Scientific 2008
戸田新細菌学
南山堂 2007

Lectures and oral presentations (204)：

SARS-CoV-2に対する抗ウイルス活性を有する海洋天然物の探索と作用機序解明
(日本薬学会第143年会 2023)
新型コロナウイルス感染マウスにおける宿主応答解析
(第69回日本ウイルス学会学術集会 2022)
Vero細胞馴化新型コロナウイルスの性状解析 Characterization of Vero cells-adapted SARS-CoV-2 strain
(第68回日本ウイルス学会学術集会 2022)
高増殖性新型コロナウイルスを用いた不活化ワクチンの開発
(第26回日本ワクチン学会学術集会 2022)
プラス鎖RNAウイルスに対して広域的に抗ウイルス活性を示すヌクレオシドアナログの探索
(第69回日本ウイルス学会学術集会 2022)

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Works (2)：

バイオテクノロジーによるワクチンの創製と改良技術の開発
1998 - 2001
Development of new vaccine by using biotechnology
1998 - 2001

Education (4)：

- 1980 Hokkaido University
- 1980 Hokkaido University Graduate School, Division of Veterinary Medicine
- 1978 University of Miyazaki Faculty of Agriculture Department of Veterinary Sciences
- 1978 University of Miyazaki Faculty of Agriculture

Professional career (1)：

Doctor of Veterinary Medicine (Hokkaido University)

Work history (8)：

1982 - 2000 国立感染症研究所研究官
1982 - 2000 National Institute of Infections Diseases, Research Official
2000 - - 大阪大学微生物病研究所教授
2000 - - Research Institute for Microbial Diseases, Professor
1984 - 1986 University of Oxford

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Committee career (1)：

2000 - 2003 日本ウイルス学会理事

Awards (4)：

2014/07 - 大阪大学大阪大学総長顕彰
2013/11 - 公益財団法人野口英世記念会第56回野口英世記念医学賞
1995 - 1995 ウイルス学会杉浦奨励賞受賞
1995 - ウイルス学会杉浦奨励賞

Association Membership(s) (5)：

米国ウイルス学会 , 日本獣医学会 , 日本癌学会 , 日本分子生物学会 , 日本ウイルス学会

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