Yuasa Hiroaki

ユアサヒロアキ | Yuasa Hiroaki

Affiliation and department：
Job title： Professor
Homepage URL (2)： http://www.phar.nagoya-cu.ac.jp/hp/yzg , http://www.phar.nagoya-cu.ac.jp/hp/yzg/e-index.html

Research field (1)： Clinical pharmacy

Research keywords (4)： drug therapy , transporter , drug disposition , drug development

Research theme for competitive and other funds (8)：

2020 - 2023 新規ポリアミントランスポーターの機能及び生理的役割の解明
2013 - 2016 Nucleobase Transport Function of Aquaporin 10: Its Role in the Intestinal Absorption of Nucleobases and Analogous Drugs
2011 - 2012 Functional Characteristics of a Novel Transporter Specifically Expressed in the Endoplasmic Reticulum in Dendritic Cells and its Role in Immune System
2008 - 2010 Identification and Functional Analysis of the Na^+-Dependent Glycerol Transporter in HCT-15 Cells
2006 - 2007 Molecular and Functional Characteristics of Glycerol Transporter in HCT-15 Cell Model

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Papers (119)：

Shogo Akino, Tomoya Yasujima, Takahiro Yamashiro, Hiroaki Yuasa. Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H⁺-driven lysosomal pyridoxine exporter. Life Science Alliance. 2023. 6. 2. e202201629-e202201629
Kohei Miyake, Tomoya Yasujima, Syunsuke Takahashi, Takahiro Yamashiro, Hiroaki Yuasa. Identification of the amino acid residues involved in the species-dependent differences in the pyridoxine transport function of SLC19A3. Journal of Biological Chemistry. 2022. 298. 8
Takahiro Yamashiro, Tomoya Yasujima, Hiroaki Yuasa. Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine. Drug Metabolism and Pharmacokinetics. 2022. 44. 100456
Yutaro Shinoda, Takahiro Yamashiro, Akira Hosooka, Tomoya Yasujima, Hiroaki Yuasa. Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter. Drug Metabolism and Pharmacokinetics. 2022. 43. 100443
Tomoki Kabeya, Shinji Mima, Yuki Imakura, Toshihide Miyashita, Izumi Ogura, Tadanori Yamada, Tomoya Yasujima, Hiroaki Yuasa, Takahiro Iwao, Tamihide Matsunaga. Pharmacokinetic functions of human induced pluripotent stem cell-derived small intestinal epithelial cells. Drug Metabolism and Pharmacokinetics. 2020. 35. 4. 374-382

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MISC (14)：

保嶋智也, 湯浅博昭. 【高尿酸血症Update】尿酸の全身動態を支配する代謝酵素・トランスポーター. 日本腎臓病薬物療法学会誌. 2022. 11. 2. 193-198
保嶋智也, 湯浅博昭. 【生活習慣と免疫異常】痛風の分子病態. 臨床免疫・アレルギー科. 2022. 77. 6. 657-663
Hiroaki Yuasa, Tomoya Yasujima, Katsuhisa Inoue. Current understanding of the intestinal absorption of nucleobases and analogs. Biological and Pharmaceutical Bulletin. 2020. 43. 9. 1293-1300
井上勝央, 湯浅博昭. 【トランスポーターのすべて】薬剤応答性とトランスポーター核酸塩基トランスポーターSLC43A3/ENBT1の輸送特性とガンシクロビルを用いた自殺遺伝子療法における役割. 医学のあゆみ. 2019. 271. 1. 122-127
湯浅博昭. 【ビタミンこの古くて新しき世界】水溶性ビタミン類の腸管吸収に関わるトランスポーター群. ファルマシア. 2015. 51. 3. 201-205

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Patents (1)：

小腸上皮細胞特異的な尿酸トランスポーター及びその利用

Books (5)：

Drug absorption from the colon in situ
"Drug Absorption Studies: In Situ, In Vitro and In Silico Models" ed. by Carsten Ehrhardt and Kwang-Jin Kim, Springer, New York, NY, pp. 77 - 88 (Ch. 3) 2008
消化管吸収の評価法
「分子薬物動態学」,杉山雄一,楠原洋之編,南山堂,東京,pp. 447 - 459(第24章) 2008
消化管吸収性の予測:in vitroからin vivoへ
「薬物バイオアベイラビリティ評価と改善の科学:より良き医薬品開発のために」,杉山雄一編,現代医療社,東京,pp. 229 - 245(第7章,第1部) 1998
腸管吸収の予測:in vitroからin vivoへ
「ファーマコキネティクス研究の方法と技術」,日本薬物動態学会ワークショップ実行委員会編,日本薬物動態学会,東京,pp. 169 - 181(第8章) 1993
薬物生体膜輸送のヒトへの外挿
「続医薬品の開発(第4巻):薬物の生体膜輸送と組織標的化II」,寺田弘,辻彰編,廣川書店,東京,pp. 518 - 523(第5章,第8節) 1991

Education (3)：

1985 - 1986 The University of Tokyo Graduate School of Pharmaceutical Sciences Ph.D. Course
1983 - 1985 The University of Tokyo Graduate School of Pharmaceutical Sciences M.S. Course (completed)
1979 - 1983 The University of Tokyo Faculty of Pharmaceutical Sciences (completed)

Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (6)：

2002 - 現在 Nagoya City University Graduate School of Pharmaceutical Sciences Professor
2000 - 2002 Nagoya City University Faculty of Pharmaceutical Sciences Professor
1992 - 2000 Nagoya City University Faculty of Pharmaceutical Sciences Associate Professor
1991 - 1992 Nagoya City University Faculty of Pharmaceutical Sciences Senior Assistant Professor
1989 - 1991 The University of Michigan College of Pharmacy Postdoctoral Fellow

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Awards (2)：

1995 - Japanese Society for the Study of Xenobiotics Young Investigator Award
1993 - Pharmaceutical Society of Japan (Tokai Chapter) Young Investigator Award

Association Membership(s) (8)：

American Society for Pharmacology and Experimental Therapeutics , International Society for the Study of Xenobiotics , International Pharmaceutical Federation , Controlled Release Society , American Association of Pharmaceutifical Scientists , Academy of Pharmaceutical Science and Technology, Japan , Japanese Society for the Study of Xenobiotics , Pharmaceutical Society of Japan

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