Rchr
J-GLOBAL ID：200901091253467367   Update date: Mar. 30, 2024

Onaka Hiroyasu

オナカ ヒロヤス | Onaka Hiroyasu
Affiliation and department：
東京大学大学院 農学生命科学研究科応用生命工学専攻

About 東京大学大学院 農学生命科学研究科応用生命工学専攻


Job title： 特任教授
Homepage URL  (2)： http://microbial-potential.bt.a.u-tokyo.ac.jp/ ,  http://microbial-potential.bt.a.u-tokyo.ac.jp/en/
Research field  (5)： Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Applied biochemistry ,  Applied microbiology ,  Molecular biology
Research keywords  (9)： 生合成 ,  抗生物質 ,  放線菌 ,  Biosynthesis ,  genetics ,  Streptomyces ,  Actinomycetes ,  Secondary metabolism ,  Antibiotics
Research theme for competitive and other funds  (17)：
  • 2021 - 2025 リボソーム翻訳後修飾ペプチド天然物の構造多様性拡張
  • 2021 - 2024 Using terpenes as a key to unlock "Black box" of microbial interactions in subseafloor
  • 2018 - 2021 the mode of action in the combined-culture methods that induce potential secondary metabolism
  • 2016 - 2021 Synthetic biology of pseudo-natural products by artificial in vitro biosynthesis
  • 2013 - 2017 Secondary metabolite Screening by combined-culture
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Papers (108)：
  • Shotaro Hoshino, Shinta Ijichi, Shumpei Asamizu, Hiroyasu Onaka. Insights into Arsenic Secondary Metabolism in Actinomycetes from the Structure and Biosynthesis of Bisenarsan. Journal of the American Chemical Society. 2023
  • Fumihiro Ishikawa, Natsumi Tsukumo, Erika Morishita, Shumpei Asamizu, Saaya Kusuhara, Shinsuke Marumoto, Katsuki Takashima, Hiroyasu Onaka, Genzoh Tanabe. Biosynthetic diversification of non-ribosomal peptides through activity-based protein profiling of adenylation domains. Chemical communications (Cambridge, England). 2023. 59. 62. 9473-9476
  • Shinta Ijichi, Shotaro Hoshino, Shumpei Asamizu, Hiroyasu Onaka. SolS-catalyzed sulfoxidation of labionin to solabionin drives antibacterial activity of solabiomycins. Bioorganic & medicinal chemistry letters. 2023. 129323-129323
  • Yukun Lei, Shumpei Asamizu, Takumi Ishizuka, Hiroyasu Onaka. Regulation of Multidrug Efflux Pumps by TetR Family Transcriptional Repressor Negatively Affects Secondary Metabolism in Streptomyces coelicolor A3(2). Applied and environmental microbiology. 2023. 89. 3. e0182222
  • Manami Kato, Shumpei Asamizu, Hiroyasu Onaka. Redox-active compound generated by bacterial crosstalk induces hypha branching inStreptomycesspecies. 2023
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MISC (52)：
  • 浅水俊平, 尾崎太郎, 尾崎太郎, 西村慎一, 西村慎一, 掛谷秀昭, 尾仲宏康. 複合培養におけるStreptomyces sp.HEK616による5aTHQの生産機構. 日本農芸化学会大会講演要旨集(Web). 2019. 2019
  • 浅水俊平, 浅水俊平, 尾崎太郎, 西村慎一, 掛谷秀昭, 尾仲宏康, 尾仲宏康. Streptomyces sp.HEK616とTsukamurella pulmonisとの複合培養での二次代謝活性化機構の解析. 日本放線菌学会大会講演要旨集. 2019. 34th
  • 林昌平, 林昌平, 尾崎太郎, 尾崎太郎, 浅水俊平, 尾仲宏康, 大村智, 供田洋, 池田治生, 奥直也, et al. Genome mining reveals a minimum gene set for the biosynthesis of 32-membered macrocyclic thiopeptides lactazoles. Institute for Fermentation, Osaka. Research Communications. 2018. 32
  • 浅水俊平, 尾崎太郎, 尾仲宏康, 佐藤勝也, 寺本華奈江, 寺本華奈江. Requirement of live mycolic acid-containing bacteria for induction of antibiotic production by Streptomyces in combined-culture. Institute for Fermentation, Osaka. Research Communications. 2018. 32
  • 浅水俊平, 菅井佳宣, 尾崎太郎, 尾仲宏康, 佐藤勝也, 大野豊. Analysis of response deficient mutants of Streptomyces coelicolor generated by heavy ion beam induced mutagenesis to contact-dependent stimuli by Tsukamurella pulmonis. Institute for Fermentation, Osaka. Research Communications. 2018. 32
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Education (2)：
  • - 1993 The University of Tokyo
  • - 1993 The University of Tokyo Faculty of Agriculture
Professional career (1)：
  • Ph.D (The University of Tokyo)
Awards (3)：
  • 2008 - 日本農芸化学会奨励賞
  • 2005 - 日本放線菌学会浜田賞
  • 2004 - 日本農芸化学会BBB論文賞
Association Membership(s) (2)：
日本放線菌学会 ,  日本農芸化学会
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