Research theme for competitive and other funds (14)：
2017 - 2021 細胞中心方向物質輸送機構の構造基盤解明
2017 - 2020 Light-mediated regulation of flagellar and ciliary motility by a novel photoreceptor protein
2014 - 2017 ダイニン運動制御機構の構造基盤解明
2012 - 2016 構造から迫る細胞内輸送マシナリー
2011 - 2014 巨大モーター蛋白質ダイニンのX線結晶構造解析による作動機構の解明
2008 - 2011 Structure and mechanism of cytoplasmic dynein
2008 - 2010 ダイニンの構造解析に基づいた、AAA型分子モーター作動機構の解明
2005 - 2009 Molecular Mechanism of energy transduction of dynein revealed by genetic engineering, structural and enzyme kinetics studies
2004 - 2008 Regulation of information flow by motor protein systems
2005 - 2007 AAA型分子モーター、ダイニンの作動メカニズム解明
2003 - 2004 Studies on Molecular Mechanism of Force Generation by Recombinant Dynein
2001 - 2002 Molecular design of the single-headed processive myosin
Studies on force generating mechanism of molecular motors
Molecular mechanism of cell motility
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Papers (60)：
Ryosuke Yamamoto, Takahide Kon. Functional and structural significance of the inner-arm-dynein subspecies d in ciliary motility. Cytoskeleton (Hoboken, N.J.). 2024
Shintaroh Kubo, Tomohiro Shima, Takahide Kon, Shoji Takada. Key residue on cytoplasmic dynein for asymmetric unbinding and unidirectional movement along microtubule. 2022
Ryosuke Yamamoto, Juyeon Hwang, Takashi Ishikawa, Takahide Kon, Winfield S. Sale. Composition and function of ciliary inner-dynein-arm subunits studied in Chlamydomonas reinhardtii. Cytoskeleton. 2021
Osamu Kutomi, Ryosuke Yamamoto, Keiko Hirose, Katsutoshi Mizuno, Yuuhei Nakagiri, Hiroshi Imai, Akira Noga, Jagan Mohan Obbineni, Noemi Zimmermann, Masako Nakajima, et al. A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light. Science advances. 2021. 7. 9
Ryosuke Yamamoto, Shiho Yanagi, Masahito Nagao, Yuya Yamasaki, Yui Tanaka, Winfield S. Sale, Toshiki Yagi, Takahide Kon. Mutations in PIH proteins MOT48, TWI1 and PF13 define common and unique steps for preassembly of each, different ciliary dynein. PLOS Genetics. 2020. 16. 11. e1009126-e1009126
Narutoshi Kamiya, Tadaaki Mashimo, Yu Takano, Takahide Kon, Genji Kurisu, Haruki Nakamura. Elastic Property of Dynein Motor Domain Obtained from All-Atom Molecular Dynamics Simulations in Explicit Water. BIOPHYSICAL JOURNAL. 2015. 108. 2. 466A-466A
S. Uchimura, T. Fujii, H. Takazaki, R. Ayukawa, Y. Nishikawa, Itsushi Minoura, Y. Hachikubo, G. Kurisu, K. Sutoh, T. Kon, et al. A Mechanical Switch from Diffusion to Directional Motion Activates ATPase in Dynein Motor. Biophysical Journal. 2015. 108. 2 Suppl. 22a
Kamiya Narutoshi, Mashimo Tadaaki, Takano Yu, Kon Takahide, Kurisu Genji, Nakamura Haruki. 1P155 Elastic property of dynein motor domain obtained from all-atom molecular dynamic simulations in explicit water(11. Molecular motor,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)). Seibutsu Butsuri. 2014. 54. 1. S166
Stanley A. Burgess, Takahide Kon, Peter J. Knight, Kazuo Sutoh. Mechanistic Insights of Dynein Motor Action from Electron Microscopy Studies. BIOPHYSICAL JOURNAL. 2014. 106. 2. 232A-232A
1993 - 1995 Tokyo Institute of Technology Bioscience and Biotechnology
1989 - 1993 Tokyo Institute of Technology School of Science
Professional career (2)：
PhD (The University of Tokyo)
MSc (Tokyo Institute of Technology)
Work history (6)：
2015 - 現在 Osaka University Graduate School of Science
2013 - 2015 Hosei University Faculty of Bioscience and Applied Chemistry
2010 - 2013 Osaka University Institute for Protein Research
2007 - 2010 The University of Tokyo Graduate School of Arts and Sciences
2000 - 2007 The University of Tokyo Graduate School of Arts and Sciences
1995 - 1997 日本ロシュ 応用微生物部 研究員
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Association Membership(s) (9)：
THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN
, PROTEIN SCIENCE SOCIETY OF JAPAN
, Biophysical Society
, The American Society for Cell Biology
, 日本生物物理学会
, Biophysical Society
, The American Society for Cell Biology
, The Biophysical Society of Japan
, Japan Society for Cell Biology
