Rchr
J-GLOBAL ID：200901092726320810   Update date: Mar. 30, 2024

Nakamichi Yuko

ナカミチ ユウコ | Nakamichi Yuko
Affiliation and department：
Matsumoto Dental University Institute for Oral Science, Division of Hard Tissue Research

About Matsumoto Dental University Institute for Oral Science, Division of Hard Tissue Research


Job title： Associate Professor
Other affiliations (1)：
  • Washington University in St. Louis  Division of Biology & Biomedical Sciences   Visiting Scholar
Research field  (3)： Oral medicine ,  Functional biochemistry ,  Laboratory animal science
Research keywords  (9)： Vitamin D ,  Osteoblast ,  Wnt ,  ビタミンD ,  骨芽細胞 ,  骨代謝 ,  破骨細胞 ,  Bone remodeling ,  Osteoclast
Research theme for competitive and other funds  (51)：
  • 2023 - 2026 Identification of a calcium paradox factor through transcriptomic and secretomic analysis of osteoblasts
  • 2022 - 2026 細胞種特異的老化モデル創出による老化細胞除去機構の解明と抗フレイル戦略の開拓
  • 2022 - 2025 Elucidation of the mechanism of action of Siglec-15 antibody drugs in the treatment of secondary osteoporosis during growth and development
  • 2021 - 2025 Anlysis of the RANKL-Siglec-15 signal molecular mechanism for alveolar bone regeneration
  • 2020 - 2024 Identification of regulators of bone regeneration using multiple modes of CRISPR-Cas9 genetic screens
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Papers (61)：
  • Tohru Hosoyama, Minako Kawai-Takaishi, Hiroki Iida, Yoko Yamamoto, Yuko Nakamichi, Tsuyoshi Watanabe, Marie Takemura, Shigeaki Kato, Akiyoshi Uezumi, Yasumoto Matsui. Lack of vitamin D signalling in mesenchymal progenitors causes fatty infiltration in muscle. Journal of cachexia, sarcopenia and muscle. 2024
  • Yuko Nakamichi, Ziyang Liu, Tomoki Mori, Zhifeng He, Hisataka Yasuda, Naoyuki Takahashi, Nobuyuki Udagawa. The vitamin D receptor in osteoblastic cells but not secreted parathyroid hormone is crucial for soft tissue calcification induced by the proresorptive activity of 1,25(OH)2D3. The Journal of steroid biochemistry and molecular biology. 2023. 232. 106351-106351
  • Takafumi Mizuno, Tohru Hosoyama, Makiko Tomida, Yoko Yamamoto, Yuko Nakamichi, Shigeaki Kato, Minako Kawai-Takaishi, Shinya Ishizuka, Yukiko Nishita, Chikako Tange, et al. Influence of vitamin D on sarcopenia pathophysiology: A longitudinal study in humans and basic research in knockout mice. Journal of cachexia, sarcopenia and muscle. 2022. 13. 6. 2961-2973
  • 何 治鋒, 溝口 利英, 平賀 徹, 中道 裕子, 山下 照仁, 小出 雅則, 宇田川 信之, 小林 泰浩. マクロファージはLepR陽性細胞を活性化し骨再生を促進する(Macrophages promote bone regeneration through the activation of LepR(+) cells). Journal of Oral Biosciences Supplement. 2022. 2022. 166-166
  • Hyun-Taek Kim, Paolo Panza, Khrievono Kikhi, Yuko Nakamichi, Ann Atzberger, Stefan Guenther, Clemens Ruppert, Andreas Guenther, Didier Y R Stainier. WNT/RYK signaling functions as an antiinflammatory modulator in the lung mesenchyme. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 24. e2201707119
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MISC (39)：
  • 玉井雅人, 宇野智, 山田悟生, 中村翔太郎, 曽我皓平, 中道裕子, 小出雅則, 高野智弘, 宇多川信之, 清野宏, et al. Roles of IL-4 in developing bone loss associated with food allergic enteropathy. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
  • 何治鋒, 溝口利英, 平賀徹, 村上康平, 中道裕子, 山下照仁, 小出雅則, 宇田川信之, 小林泰浩. マクロファージはLepR陽性細胞を活性化し骨再生を促進する. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2021. 39th
  • 何治鋒, 平賀徹, 石莉楠, 李若萱, 中道裕子, 中道裕子, 山下照仁, 山下照仁, 小出雅則, 小出雅則, et al. Macrophages promote bone regeneration through the activation of LepR(+)cells. 松本歯学. 2021. 47. 2
  • 鶴田敏博, 小出雅則, 中道裕子, 中村美どり, 宇田川信之, 北村和雄. Osteoprotegerin: a possible protective factor for cardiovascular system. Journal of Oral Biosciences Supplement (Web). 2020. 2020
  • 松下雅衣, 小出雅則, 芳澤享子, 堀部寛治, 小林泰浩, 山下照仁, 中道裕子, 上原俊介, 宇田川信之. Long-term observation of sclerostin expression in BMP-induced ectopic bone. Journal of Oral Biosciences Supplement (Web). 2020. 2020
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Books (6)：
  • Vitamin D; 5th Edition, Chapter 20 - Osteoclastogenesis and Vitamin D
    Academic Press 2023
  • Encyclopedia of Bone Biology; Vitamin D in The Regulation of Osteoclasts Pages 290-302
    Academic Press 2020
  • Chapter 18 - Osteoclastogenesis and Vitamin D
    Academic Press 2018
  • Keyword M-CSF/IL-34 骨ペディア 骨疾患・骨代謝キーワード事典
    日本骨代謝学会編/羊土社 2015
  • Encyclopedia of Bone Biology;Osteoclast Cell Lineage: Characteristics and Behavior of Osteoclast Precursors In Vivo Pages 181-192
    Academic Press 2014
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Lectures and oral presentations  (11)：
  • 活性型ビタミンDによるカルシウム代謝制御における骨芽細胞のビタミンD受容体(VDR)とWntシグナルの役割
    (九州歯科大学 大学院特別講義 2023)
  • The vitamin D receptor in osteoblastic cells controls disease outcomes of disorders of Ca and P metabolism.
    (Weekly seminar @ Major lab (WashU, St. Louis) 2023)
  • The Vitamin D Receptor (VDR) in Osteoblastic Cells but Not Parathyroid Hormone (PTH) Secretion Is Critical for Soft tissue Calcification Induced by the Proresorptive Activity of 1,25(OH)2D3
    (2023)
  • 活性型ビタミンDの骨吸収促進作用による軟組織の石灰化に、副甲状腺ホルモンは関与せず、骨芽細胞内のビタミンD受容体が決定的な役割を果たす
    (第65回歯科基礎医学会学術大会 2023)
  • 活性型ビタミンDの骨吸収促進作用による軟組織の石灰化に、副甲状腺ホルモンは関与せず、骨芽細胞内のビタミンD受容体が決定的な役割を果たす
    (第41回日本骨代謝学会学術集会 2023)
ｍore...
Education (5)：
  • - 2002 The University of Tokyo
  • - 2002 The University of Tokyo Graduate School of Agricultural and Life Sciences Department of Applied Biological Chemistry
  • - 1998 The University of Tokyo
  • - 1996 Tokyo University of Science Faculty of Science, Division 1 Chemistry
  • - 1996 Tokyo University of Science Faculty of Science Chemistry
Professional career (1)：
  • PhD (The University of Tokyo)
Work history (7)：
  • 2022/04 - Matsumoto Dental University Institute for Oral Science Associate Professor
  • 2017/09 - 2019/09 ノースカロライナ大学チャペルヒル校ラインバーガー癌センター 客員研究員
  • 2011 - - 松本歯科大学 総合歯科医学研究所 講師
  • 2011 - - Assistant Professor, Institute for Oral Science
  • 2007 - - 松本歯科大学 総合歯科医学研究所 助教
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Committee career (8)：
  • 2014/09 - 現在 JSBMR JBMM Editorial board member
  • 2014/09 - 現在 日本骨代謝学会誌 Journal of Bone and Mineral Metabolism Editorial board
  • - 2017/07 JSBMR 35th Annual Meeting Program Committee Member
  • - 2017/07 日本骨代謝学会 第35回 日本骨代謝学会プログラム選定委員
  • - 2016/07 JSBMR 34th Annual Meeting Program Committee Member
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Awards (6)：
  • 2022/09 - 24th Vitamin D Workshop Plenary Poster Award
  • 2017 - 20th Vitamin D Workshop Plenary Poster Award
  • 2016 - 第2回 Neo Vitamin D workshop 優秀演題賞
  • 2012/06 - 4th International Conference on Osteoimmunology Travel Award
  • 2004 - アメリカ骨代謝学会 Young Investigator Award
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Association Membership(s) (7)：
松本歯学会 ,  JAOB ,  Japanese Society of Osteoimmunology ,  米国骨代謝学会 ,  日本骨代謝学会 ,  ASBMR ,  JSBMR
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