- 2018 - 2021 Identification of the genes for mechanical stress diseases
- 2017 - 2019 Analysis on the pathogenesis of idiopathic scoliosis using Gpr126 conditional knock-out mice
- 2017 - 2019 Systematic sequence analysis for early onset skeletal dysplasia
- 2016 - 2019 Mechanism of biosynthesis of glycosaminoglycan by Golgin, and its hereditary bone and skin disorders
- 2013 - 2016 Roles of chondroitin sulfate interacting with RAGE involved in tumor and Alzheimer's disease
- 2011 - 2013 骨系統疾患の疾患遺伝子と分子病態の解明
- 2011 - 2012 Pathogenic mechanisms of the bone diseases caused by defect in chondroitin sulfate biosynthesis
- 2009 - 2011 Identification of susceptibility gene for lumbar disc disease and clarification of its molecular pathogenesis
- 2008 - 2010 Identification of the causative genes and investigation of the molecular pathogenesis for skeletal dysplasias
- 2007 - 2008 Identification of susceptibility gene for lumbar disc herniation and clarification of its molecular pathogenesis
- 2006 - 2007 Identification of the genes for skeletal dysplasia and onstruction of its diagnostic system
- 2005 - 2006 Molecular pathogenesis of lumbar disc degeneration
- 2002 - 2004 Regeneration of Articular Cartilage Tissue from Cultured Chondrocytes using a Photo-polymerizing Gelatin as a Cell Carrier
- 2002 - 2004 Study of the function of cystatin 10, a novel chondrocyte-specific gene.
- 2002 - 2003 Analysis of disease genes for skeletal dysplasias
- 2001 - 2003 Regulation of bona and cartilage metabolism by nucleotide pyrophosphatase (NPPS) -skeletal analysis of ttw mice and its contribution to the human npps gene SNPs -
- 1999 - 2000 Genetic analysis and diagnosis of skeletal dysplasias
- 1997 - 1998 Genetic analysis of skeletal dysplasias
- 1996 - 1998 LINKAGE ANALYSIS OF UNKNOWN GENETIC DISEASES
- 変形性関節症の感受性遺伝子の同定
- 変形性関節症の治療薬の開発
- 椎間板疾患の分子診断法の開発
- 椎間板疾患治療薬の開発
- 椎間板疾患関連遺伝子の機能解析
- 疾患のリスク診断、遺伝子診断
- 相関解析
- 軟骨細胞の機能解析
- インビトロ軟骨形成モデル
- SNP タイピング
- 相関解析により同定した変形性関節症感受性遺伝子の分子病態の解明を突破口に、変形性関節症の治療薬を開発
- 相関解析により同定した新規疾患感受性遺伝子、LDD1(特許申請中)の分子病態の解明を突破口に、椎間板ヘルニアの治療薬を開発
- 臨床機関、遺伝子多型センターの他チームとの連係のもとに、椎間板ヘルニア(椎間板変性症)の患者サンプルを用いて、遺伝統計学的解析(相関解析、連鎖解析)、発現解析(細胞、患者組織)を行い、椎間板ヘルニアの疾患感受性遺伝子を同定
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