Sasajima Toshio

• 2010 - 2012 Experimental studies of synthesized amino acid analog anti-FACBC as imaging biomarker to monitor treatment response of glioblatomas to temozolomide therapy with interferon-. and bevacizumab
• 2008 - 2010 Development of a novel multi-modal surgical navigation system with the integration of three-dimensional cerebrovascular imaging data.
• 2007 - 2008 Experimental studies of CD133(+) glioblastoma stem cells under normoxic and hypoxic conditions
• 2006 - 2007 Development of the multimodal neuronavigation system integrating structural and functional information in combination with intra-operative ultrasound imaging.
• 2004 - 2005 Establishment of cortical mapping of speech areas by multimodal functional image fusions using neuronavigation system
2004 - 2005 Experimental studies on potentiation of antitumor agent by the second generation MDR1 inhibitors in malignant brain tumors : Monitoring multidrug resistance using ^<99m>Tc-MIBI
2002 - 2003 Integrated analysis of language area using MEG, functional MRI and PET. -Clinical application to brain tumor surgery-
2000 - 2001 Experimental studies of antitumor effects ofangiogenesis inhibitor TNP-470 with a chemotherapeutic agent on a malignant brain tumor.
1999 - 2000 Monitoring the functional expression of multidrug resistance gene (MDR1) and study on potentiation of antitumor agent by MDR1 inhibitors in brain tumors.
1997 - 1998 脳腫瘍における低酸素細胞の増殖能と糖およびアミノ酸代謝に関する研究
1994 - 1994 脳腫瘍における腫瘍壊死因子動注療法による循環代謝の変動と治療効果に関する研究
1993 - 1993 脳腫瘍におけるアミノ酸代謝とシスプラチンの作用機序に関する研究
Experimental studies of antitumor effects of angiogenesis inhibitor TNP-470 with a chemotherapeutic agent on maliqnant gliomas.

• Takahiro Ono, Toshio Sasajima, Yoshihiro Doi, Shuntaro Oka, Masahiro Ono, Masaru Kanagawa, Atsumi Baden, Kazuo Mizoi, Hiroaki Shimizu. Amino acid PET tracers are reliable markers of treatment responses to single-agent or combination therapies including temozolomide, interferon-beta, and/or bevacizumab for glioblastoma. NUCLEAR MEDICINE AND BIOLOGY. 2015. 42. 7. 598-607
• Mishie Tanino, Toshio Sasajima, Hiroshi Nanjo, Shiori Akesaka, Masami Kagaya, Taichi Kimura, Yusuke Ishida, Masaya Oda, Masataka Takahashi, Taku Sugawara, et al. Rapid immunohistochemistry based on alternating current electric field for intraoperative diagnosis of brain tumors (vol 32, pg 12, 2015). BRAIN TUMOR PATHOLOGY. 2015. 32. 1. 20-21
• Mishie Tanino, Toshio Sasajima, Hiroshi Nanjo, Shiori Akesaka, Masami Kagaya, Taichi Kimura, Yusuke Ishida, Masaya Oda, Masataka Takahashi, Taku Sugawara, et al. Rapid immunohistochemistry based on alternating current electric field for intraoperative diagnosis of brain tumors. BRAIN TUMOR PATHOLOGY. 2015. 32. 1. 12-19
• Takeo Uzuka, Kenichiro Asano, Toshio Sasajima, Kaori Sakurada, Toshihiro Kumabe, Takaaki Beppu, Masahiro Ichikawa, Chifumi Kitanaka, Hiroshi Aoki, Kiyoshi Saito, et al. Treatment outcomes in glioblastoma patients aged 76 years or older: a multicenter retrospective cohort study. JOURNAL OF NEURO-ONCOLOGY. 2014. 116. 2. 299-306
• Toshio Sasajima, Takahiro Ono, Naoya Shimada, Yoshihiro Doi, Shuntaro Oka, Masaru Kanagawa, Atsumi Baden, Kazuo Mizoi. Trans-1-amino-3-F-18-fluorocyclobutanecarboxylic acid (anti-F-18-FACBC) is a feasible alternative to C-11-methyl-L-methionine and magnetic resonance imaging for monitoring treatment response in gliomas. NUCLEAR MEDICINE AND BIOLOGY. 2013. 40. 6. 808-815

ｍore...

• 高橋 和孝, 松本 康史, 山口 卓, 小野 隆裕, 小田 正哉, 笹嶋 寿郎, 清水 宏明. 血管内治療と二期的摘出術が有用であった大型・hypervascular聴神経腫瘍の1手術例. 脳神経外科ジャーナル. 2015. 24. 8. 544-551
• 廣嶋 優子, 南條 博, 前田 大地, 後藤 明輝, 笹嶋 寿郎, 清水 宏明, 南谷 佳弘, 津田 真寿美, 田中 伸哉. 迅速免疫組織化学染色を用いた膠腫におけるIDH1染色の術中応用. 日本病理学会会誌. 2015. 104. 1. 296-296
• 南條 博, 吉岡 年明, 廣嶋 優子, 南谷 佳弘, 笹嶋 寿郎, 吉田 誠, 後藤 明輝, 大森 泰文, 中村 竜太, 赤上 陽一. 迅速免疫染色技術(R-IHC)を用いた術中迅速病理診断 当院における180症例の検討. 日本病理学会会誌. 2015. 104. 1. 465-465
• 笹嶋 寿郎. 【神経症候群(第2版)-その他の神経疾患を含めて-】 腫瘍性疾患 神経上皮性腫瘍 そのほかの神経上皮性腫瘍 第三脳室脊索腫様膠腫. 日本臨床. 2014. 別冊. 神経症候群III. 105-108
• 南條 博, 南谷 佳弘, 伊藤 智, 成田 かすみ, 川村 学, 廣嶋 優子, 吉岡 年明, 後藤 明輝, 笹嶋 寿郎, 赤上 陽一. 新しい細胞診機器・技術 機械化・LBC・画像解析 電界非接触撹拌迅速免疫染色技術(R-IHC法)の開発と組織・細胞診断への活用. 日本臨床細胞学会雑誌. 2014. 53. Suppl.1. 116-116

ｍore...

• Early effects of intracarotid recombinant human tumor necrosis factor α on cerebral blood flow and glucose metabolism
  Clinical PET in Oncology 1994

• - 1991 Akita University
• - 1991 Akita University Graduate School, Division of Medicine Neurosurgery
• - 1986 Akita University School of Medicine School of Medicine
• - 1986 Akita University Faculty of Medicine

日本小児脳神経外科学会 ,  日本脳神経外科コングレス ,  日本脳神経CI学会 ,  International Society for Cerebral Blood Flow and Metabolism ,  日本癌治療学会 ,  日本脳神経外科学会 ,  The Japanese Society for Pediatric Neurosurgery ,  The Japanese Congress of Neurological Surgeons ,  The Japan Society for CNS Computed Imaging ,  International Society for Cerebral Blood Flow and Metabolism ,  Japan Society of Clinical Oncology ,  The Japan Neurosurgical Society