Shima Hiroshi

2016 - 2019 Identification of a protein phosphatase which involved in brain tumororigenesis.

2016 - 2019 Cellular senescence induced by chemo/radio-therapy as new therapeutic opportunity of mammary tumors.

2016 - 2018 Insufficiency of a novel anti-oncogene and mouse ovarian tumorigenesis

2015 - 2018 PP6 as a tumor suppressor in mouse two-stage chemical carcinogenesis

2015 - 2018 Identification of the responsible PPase that stabilyze cell cycle regulator Cdc25B

2014 - 2017 Tumor promotion associated with Ppp6c-deficiency.

2014 - 2016 Possible interplay between metabolism and genomic instability during epithelial oncogenesis

2012 - 2015 Phosphatome - targeted therapy for breast cancer

2012 - 2014 Possible interdependence between Warburg effect and genomic instability during colorectal cancer development

2011 - 2013 Development of a novel therapy by targeting Warburg effect of gliomas.

2010 - 2012 Regulation of KIF3 motor by dephosphorylation

2010 - 2012 Aberrant pre-mRNA splicinginvolved in increased fluxof glycolysis in non-small lung cancer

2008 - 2010 Therapeutic effect of the polymeric micellar antineoplastic drugs infused convection-enhanced delivery against intracranial rat glioma models

2008 - 2009 中枢神経系悪性リンパ腫の発生機序に関する研究

2007 - 2009 Development of genetic diagnosis and drugs for lung cancer, based on protein phosphatase targeting

2007 - 2008 Regulation of cell function by protein phosphatases

1998 - 2008 The regulation of mRNA processing by phosphorylation

1998 - 2008 The role of phosphorylation of proteins in carcinogenesis and immune suppression phosphorylation

2005 - 2006 mRNA翻訳効率に対する転写過程での刷り込み現象

2004 - 2006 Regulation of cell function by protein dephosphorylation

2002 - 2005 Molecular mechanisms and their significance of protein phosphatase families which control the network-system of signal transduction

2002 - 2003 Regulation of translation by protein phosphorylation.

2001 - 2001 2重特異性ホスファターゼによる細胞増殖の制御・その破綻による制御異常の解析

2000 - 2001 Regulatgion of translation by protein phosphorylation.

1998 - 2001 Studies on control mechanism of protein phosphatases ds a network system of information

2000 - 2000 S6キナーゼを中心とする翻訳制御の細胞増殖,発がんにおける関与

1999 - 1999 Tリンパ球におけるS6キナーゼの機能とその制御機構の研究

1994 - 1994 発癌過程ならびに癌細胞形質の発現におけるプロテインホスファターゼの意義

1993 - 1993 発癌過程ならびに癌細胞形質の発現におけるプロテインホスファターゼの意義

1992 - 1992 発癌過程ならびに癌細胞形質の発現におけるプロテインホスファターゼの意義

がんにおける染色体・遺伝子の不安定性機構の解明

スプライシングを標的とするがんの診断・治療の開発

プロテインホスファターゼを標的とした、がんの診断・治療の開発