Hirata Azumi

Affiliation and department：
Job title： Associate Professor

Research field (1)： Oral medicine

Research keywords (2)：口腔解剖学 , Oral histology

Research theme for competitive and other funds (22)：

2022 - 2026 Structure and function of Collagen-binding protein from Streptococcus mutans
2019 - 2022 Analysis of the mechanism of cleft palate development after palatal fusion-Effect of extracellular matrixes-
2018 - 2022 Elucidation of pathogenic acquisition mechanism from the crystal structure of the collagen-binding proteins of Streptococcus mutans
2021 - 2022 疾患特異iPS細胞を用いた神経系3次元培養によるアレキサンダー病発症機序の解析
2016 - 2019 Research on metabolic mechanism of palatal processes and cleft palate onset mechanism from genes

2016 - 2019 Influence of human muscle related genes and dynamics of palatine basement membrane involved in cleft palate development

2015 - 2019 Structural analysis of collagen-binding-proteins from Streptococcus mutans

2018 - セメント芽細胞分化メカニズムの解明

2014 - 2017 a study of early stage of dental formation by a novel organ culture system

2012 - 2016 Localization of serotonin and serotonin transporter during tooth and periodontal tissue formation

2011 - 2013 A study of tooth root formation by a novel co-culture system -Three Dimensional and Layered (TDL) culture.

2010 - 2012 Localization of Perlecan and Heparanase in the Epithelial

2009 - 2011 Heparanase localization and stimulatory effect during formation and regeneration of periodontal tissues

2008 - 2010 Analysis of cleft palate pathogenesis caused by post-fusional rupture

2008 - 2010 A study of the dental root formation by extracellular environment through Perlecan?SHH interaction.

2008 - 2009 口蓋裂発生の機序解析の新展開-口蓋突起癒合時の上皮索基底膜の動態からの検討-

2007 - 2008 Molecular and genetic analysis of osteoclast differentiantion factor and osteoclastgenesis inhibitory factor in osteoporosis and control of inhibition of bone resorption by 1, 4-dihydroxy-2-naphthoic acid(DHNA)

2007 - 2008 Evaluation of Biological tissue engineering for craniomaxillofacial surgery

2008 - セメント芽細胞分化調節機構の解明に関する研究

2005 - 2006 歯の発生に係るミッドカイン(MK)の機能についての研究

2004 - 2005 セメント芽細胞分化過程における上皮鞘基底膜プロテオグリカンの動態に関する研究

2003 - Runx2およびPTHrPのセメント芽細胞分化制御に関する研究

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Papers (46)：

Akari Nishi, Hikaru Matsui, Azumi Hirata, Atsushi Mukaiyama, Shun-ichi Tanaka, Takuya Yoshizawa, Hiroyoshi Matsumura, Ryota Nomura, Kazuhiko Nakano, Kazufumi Takano. Structure, Stability and Binding Properties of Collagen-Binding Domains from Streptococcus mutans. Chemistry. 2023. 5. 3. 1911-1920
Wataru Hamada, Nahoko Kato-Kogoe, Koji Yamanegi, Hirofumi Kanetake, Azumi Hirata, Tetsuya Terada, Yoshitaka Kurisu, Hidenori Une, Yoshinobu Hirose, Tohru Nakanishi, et al. Tetraspanin CD81 is expressed in human parotid cancer tissue and mediates cell proliferation. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2023
Chisato Sakuma, Hideto Imura, Tomohiro Yamada, Azumi Hirata, Yayoi Ikeda, Masaaki Ito, Nagato Natsume. Histological and Immunohistochemical Studies to Determine the Mechanism of Cleft Palate Induction after Palatal Fusion in Mice Exposed to TCDD. International Journal of Molecular Sciences. 2022. 23. 4. 2069-2069
Tanaka SI, Tsutaki M, Yamamoto S, Mizutani H, Kurahashi R, Hirata A, Takano K. Exploring mutable conserved sites and fatal non-conserved sites by randam mutation of esterase from Sulfolobus tokodai and subtilisin from Thermococcus kodakarensis. Int J Biological Macromolecules. 2021. 170. 343-353
Sakudo A, Imanishi Y, Hirata A, Koga Y, Shintani H. Effect of nitrogen gas plasma generated by a fast pulsed power supply using a static induction thyristor on scrapie prion. Pathogens. 2020. 9. 10. 819

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MISC (15)：

林真凜, 田中晶子, 中野旬之, 米戸邦夫, 米戸千賀, 平田あずみ, 小越菜保子, 中島世市郎, 鈴木慶, 植野高章, et al. Therapeutic effects of hyaluronic acid sheets on oral mucositis. 日本薬剤学会年会講演要旨集(CD-ROM). 2022. 37th
平田あずみ, 井村英人, 山田朋弘, 植野高章, 三島克章, 南克浩, 夏目長門, 菅原利夫. Homeobox family HOXC遺伝子は口蓋形成に関与する. 日本口腔外科学会雑誌. 2010. 56. Suppl. 211-211
井村英人, 平田あずみ, 山田朋弘, 南克浩, 新美照幸, 古川博雄, 三島克章, 藤原久美子, 鈴木聡, 菅原利夫, et al. 口唇口蓋裂に関する実験的研究(第124報) 器官培養による口蓋突起癒合時の観察. 日本口腔外科学会雑誌. 2010. 56. Suppl. 212-212
平田あずみ, 山田朋弘, 植野高章, 井村英人, 香川智正, 山近英樹, 松村達志, 森谷徳文, 三島克章, 菅原利夫. 口蓋の骨形成過程におけるヘパラン硫酸とヘパラナーゼの役割. 日本口腔外科学会雑誌. 2009. 55. Suppl. 288-288
A. Hirata, T. Tsuji, T. Ueno, T. Yamada, H. Imura, T. Kagawa, T. Matsumura, N. Moritani, K. Mishima, T. Sugahara, et al. Localization of heparanase during palatal bone formation in palatogenesis in mice. BONE. 2009. 44. 2. S294-S295

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Education (2)：

1986 - 1992 Okayama University Dental School School of Dentistry
- 1986 岡山県立岡山朝日高等学校

Professional career (1)：

博士(歯学) (岡山大学)

Work history (11)：

2021/04 - 現在大阪医科薬科大学医学部生命科学講座解剖学教室准教授
2018/04 - 2021/03 大阪医科大学生命科学講座解剖学教室准教授
2014/11 - 2018/03 大阪医科大学生命科学講座解剖学教室講師
2012/10 - 2014/10 大阪医科大学生命科学講座解剖学教室助教
2011/04 - 2012/09 京都府立大学大学院生命環境科学研究科応用生命科学専攻特任助教

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Awards (6)：

2012/10 - 公益社団法人日本口腔外科学会第57回日本口腔外科学会総会優秀ポスター賞(ゴールドリボン賞)
2010/10 - 公益社団法人日本口腔外科学会第55回日本口腔外科学会総会優秀ポスター賞(ゴールドリボン賞)
2008/10 - 公益社団法人日本口腔外科学会第53回日本口腔外科学会総会優秀ポスター賞(ゴールドリボン賞)
2007/09 - 公益社団法人日本口腔外科学会第52回日本口腔外科学会総会優秀ポスター賞(ゴールドリボン賞)
2007/08 - 一般社団法人歯科基礎医学会第19回歯科基礎医学会賞

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