Hiroi Miki

ヒロイミキ | Hiroi Miki

Affiliation and department：
Job title： research associate

Research field (2)： Oral medicine (pathology) , Oral medicine

Research keywords (14)：転写制御 , 情報伝達 , ケモカイン , サイトカイン , 遺伝子発現 , 炎症 , 免疫 , Transcriptional regulation , Signal transduction , Chemokine , Cytokine , Gene expression , Inflammation , Immunology

Research theme for competitive and other funds (9)：

2020 - 2023 Inactivation of IFN-induced chemokines by DPP4 and its clinical significance in oral cancer
2019 - 2022 口腔癌のインターフェロン耐性機構の解明と免疫エピゲノム併用療法の有効性の検討
2017 - 2020 Culture induction mechanism of tumor-associated macrophage and functionals analysis in precancerous lesions and squamous cell carcinoma
2014 - 2017 The mechanism of development of tumor-associated macrophage in oral squamous cell carcinoma
2013 - 2016 The role of the Mediator complexes in transcriptional regulation of the chemokine genes

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Papers (23)：

Ari Matsumoto, Miki Hiroi, Kazumasa Mori, Nobuharu Yamamoto, Yoshihiro Ohmori. Differential Anti-Tumor Effects of IFN-Inducible Chemokines CXCL9, CXCL10, and CXCL11 on a Mouse Squamous Cell Carcinoma Cell Line. Medical sciences (Basel, Switzerland). 2023. 11. 2
Ryosuke Ushio, Miki Hiroi, Ari Matsumoto, Kazumasa Mori, Nobuharu Yamamoto, Yoshihiro Ohmori. Enhanced Cytotoxic Effects in Human Oral Squamous Cell Carcinoma Cells Treated with Combined Methyltransferase Inhibitors and Histone Deacetylase Inhibitors. Biomedicines. 2022. 10. 4
Hana Yamaguchi, Miki Hiroi, Kazumasa Mori, Ryosuke Ushio, Ari Matsumoto, Nobuharu Yamamoto, Jun Shimada, Yoshihiro Ohmori. Simultaneous Expression of Th1- and Treg-Associated Chemokine Genes and CD4+, CD8+, and Foxp3+ Cells in the Premalignant Lesions of 4NQO-Induced Mouse Tongue Tumorigenesis. Cancers. 2021. 13. 8
Hana Yamaguchi, Miki Hiroi, Yoshihiro Ohmori. Silencing of the interferon-inducible gene Ifi204/p204 induces resistance to interferon-γ-mediated cell growth arrest of tumor cells. Cytokine. 2019. 118. 80-92
Iguchi M, Hiroi M, Kanegae H, Ohmori Y. Costimulation of Murine Osteoblasts with Interferon-γ and Tumor Necrosis Factor-α Induces Apoptosis through Downregulation of Bcl-2 and Release of Cytochrome c from Mitochondria. Mediators of inflammation. 2018. 2018. 3979606

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MISC (9)：

山口花, 廣井美紀, 大森喜弘. マウス扁平上皮癌細胞のIFN耐性における細胞増殖制御遺伝子のDNAメチル化による発現抑制. Journal of Oral Biosciences Supplement. 2014. 2014. 200-200
廣井美紀, 山口花, 大森喜弘. IL-4による一酸化窒素合成酵素遺伝子NOS2の発現抑制機構. Journal of Oral Biosciences Supplement. 2013. 2013. 211-211
山口花, 廣井美紀, 大森喜弘. マウス扁平上皮癌細胞におけるIFNγ耐性機構. Journal of Oral Biosciences Supplement. 2013. 2013. 212-212
天野滋, 関根圭輔, 廣井美紀, 大森喜弘. 破骨細胞分化に関与する核内リン酸化蛋白質の2次元電気泳動解析. Journal of Oral Biosciences. 2007. 49. Supplement
廣井美紀, 大森喜弘. p38 MAP kinaseは転写因子STAT1、NF-κBのクロストークによる相乗的な転写活性を制御する. Journal of oral biosciences. 2004. 46. 5. 416-416

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Awards (3)：

2005/10 - International Cytokine Society Ed Leonard Prize Fund for Chemotaxis/Chemokine Research
2004/10 - 歯科基礎医学会優秀ポスター賞
2004/10 - 歯科基礎医学会歯科基礎医学会賞

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