Tohda Shuji

トウダシュウジ | Tohda Shuji

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.tmd.ac.jp/med/mlab/mlab-J.html

Research field (2)： Other , Other

Research keywords (7)： Clinical microbiology , Cellular biology of leukemia , 感染症学 , Clinical hematology , Cellular and molecular biology of leukemia , Molecular diagnostic test , Laboratory Medicine

Research theme for competitive and other funds (22)：

2020 - 2023 白血病の遺伝子パネル検査とシグナル蛋白解析を統合した分子標的薬感受性検査法の開発
2017 - 2020 Companion Diagnostics to predict the effects of molecularly-targeted drugs on acute leukemia stem cells
2017 - 2019 急性白血病の幹細胞を根絶する分子標的薬の効果を予測するコンパニオン検査法の開発
2014 - 2017 Tests for self-renewal signals of acute leukemia stem cells and prediction of the effects of molecular-targeted drugs for the signals
2014 - 2016 急性白血病の症例ごとの幹細胞自己複製シグナルとその分子標的薬の効果予測の検査法

2011 - 2013 Tests for quantity and characteristics of acute leukemia stem cells to search molecular-targeted therapies suitable for each case

2008 - 2010 Role of Notch in the pathophysiology of leukemia stem cells and drug sensitivity tests for Notch inhibitors

2006 - 2007 A novel therapy targeting Notch molecule against leukemia and a method to select patients suitable for the therapy

2004 - 2005 The method to surmise the prognosis of leukemia patients by analyzing the function of Notch protein

2004 - 2005 Study on the System Detecting the Effect of the Molecular-Targeting Therapy for Leukemia and the Patients Prognosis.

2002 - 2003 Study on the System Detecting the residual Leukeinic Cells after the Gene-targeted Therapy forLeukemia

2001 - 2002 Development of the method to surmise the prognosis of acute myeloblastic leukemia patients by analyzing the expression of Notch protein

1999 - 2000 The establishment of the system that predicts the prognosis of acute leukemia patients on the basis of the biological properties of leukemic blast progenitors.

1998 - 1999 Development of the method to infer the responsiveness of acute myeloblastic leukemia cells for G-CSF

1997 - 1998 The establishment of the method which detects the minimal residual leukemic cells in acute myelogenous patients in remisson and predicts the patients prognosis.

1995 - 1995 白血病細胞における造血因子の細胞内情報伝達系の解明

1994 - 1994 B細胞リンパ腫に関与する遺伝子(BCL-5)の同定と発症メカニズムの研究

1994 - 1994 白血病細胞の増殖阻止を目的とした制癌剤とサイトカインの併用療法に関する研究

1993 - 1993 白血病細胞の増殖阻止を目的とした制癌剤とサイトカインの併用療法に関する研究

白血病の遺伝子パネル検査とシグナル蛋白解析を統合した分子標的薬感受性検査法の開発

造血器腫瘍や感染症の遺伝子診断法の開発

細胞分子生物学的手法を用いた白血病細胞の増殖機構の検査法

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Papers (260)：

Azusa Yamazaki, Yoko Nukui, Takahiro Kameda, Ryoichi Saito, Yuki Koda, Naoya Ichimura, Shuji Tohda, Ryunosuke Ohkawa. Variation in presepsin and thrombomodulin levels for predicting COVID-19 mortality. Scientific Reports. 2023. 13. 1
Yuna Takatsuki, Yuta Takahashi, Jun Nakajima, Yumi Iwasaki, Katsutoshi Nagano, Chihiro Tani-Sassa, Sonoka Yuasa, Saki Kanehira, Kazunari Sonobe, Yoko Nukui, et al. Viral load of SARS-CoV-2 Omicron BA.5 is lower than that of BA.2 despite the higher infectivity of BA.5. Immunity, Inflammation and Disease. 2023. 11. 2
Yusuke Ota, Natsune Hongou, Yoko Nukui, Ryuji Koike, Shuji Tohda, Ryoichi Saito. Evaluation of polymerase chain reaction-based open reading frame typing method for the clonality investigation of Clostridioides difficile isolates. Anaerobe. 2021. 72. 102462-102462
Nagano K, Tani-Sassa C, Iwasaki Y, Takatsuki Y, Yuasa S, Takahashi Y, Nakajima J, Sonobe K, Ichimura N, Nukui Y, et al. SARS-CoV-2 R.1 lineage variants that prevailed in Tokyo in March 2021. Journal of medical virology. 2021
Mitsumura Takahiro, Okamoto Tsukasa, Shirai Tsuyoshi, Iijima Yuki, Sakakibara Rie, Honda Takayuki, Ishizuka Masahiro, Aiboshi Junichi, Tateishi Tomoya, Tamaoka Meiyo, et al. Predictors associated with clinical improvement of SARS-CoV-2 pneumonia. JOURNAL OF INFECTION AND CHEMOTHERAPY. 2021. 27. 6. 857-863

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MISC (92)：

東田修二. 新型コロナウイルス検査の感度・特異度と検査結果の標準化. 日本臨床検査医学会誌. 2021. 69. 6. 405-409
藤井祐葵, 島野志都子, 渡部芽以, 堀内優奈, 亀田貴寛, 大野一彦, 市村直也, 東田修二, 大川龍之介. 自動分析装置による高比重リポタンパク亜分画コレステロールの測定. 臨床病理. 2020. 68
山崎あずさ, 堀内優奈, 頼劭睿, 亀田貴寛, 市村直也, 東田修二, 大川龍之介. 赤血球膜コレステロール含有量測定法の検討. 臨床病理. 2020. 68
堀内優奈, 堀内優奈, 頼劭睿, 島野志都子, 亀田貴寛, 市村直也, 東田修二, 戸塚実, 大川龍之介. 無細胞系コレステロール引き抜き能測定法におけるreference serumに代わるタンパクの探索. 臨床病理. 2020. 68
亀田貴寛, 島野志都子, 堀内優奈, 矢野康次, 頼劭睿, 市村直也, 東田修二, 栗原由利子, 戸塚実, 大川龍之介. MPO酸化修飾およびN-ホモシステイン化修飾がHDLの血管内皮修復能に及ぼす影響について. 臨床化学. 2020. 49

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Books (53)：

今日の臨床検査2021-2022
南江堂 2021
スタンダード検査血液学第4版
医歯薬出版 2021
遺伝子・染色体検査学第2版
医歯薬出版 2021
病期・病態・重症度からみた疾患別看護過程第4版
医学書院 2020
臨床検査ガイド2020年版
文光堂 2020

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Lectures and oral presentations (131)：

Inhibition of USP14 induces apoptosis in FLT3-ITD-positive AML cells through upregulation of Nrf-2
(2021)
Dramatic change of high-density lipoprotein structure and serum amyloid A distribution after orthopedic surgery
(2020 AACC Annual Scientific Meeting & Clinical Lab Expo 2020)
Novel cholesterol efflux assay using immobilized liposome-bound gel beads: confirmation and improvement for application in clinical laboratory
(2020 AACC Annual Scientific Meeting & Clinical Lab Expo 2020)
Novel cholesterol efflux assay using immobilized liposome-bound gel beads: confirmation and improvement for application in clinical laboratory
(2020 AACC Annual Scientific Meeting & Clinical Lab Expo 2020)
生化学自動分析装置を用いたアポリポタンパクE含有高比重リポタンパクコレステロール測定試薬の性能評価
(第67回日本臨床検査医学会学術集会 2020)

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Education (1)：

- 1984 Tokyo Medical and Dental University Faculty of Medicine School of Medicine

Professional career (1)：

Doctor of Medicine (Tokyo Medical and Dental University)

Work history (16)：

2019/05/01 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Comprehensive Patient Care Laboratory Medicine Professor
2015/10/01 - 現在 Tokyo Medical and Dental University Medical Hospital Central Clinical Facilities Clinical Laboratory Director
2015/09/16 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Comprehensive Patient Care Laboratory Medicine Professor
2007/04/01 - 2015/09/15 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Comprehensive Patient Care Laboratory Medicine Associate Professor
1999/04/01 - 2007/03/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Comprehensive Patient Care Laboratory Medicine

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Committee career (8)：

2011 - 2016 厚生労働省臨床検査技師国家試験試験委員
日本臨床検査専門医会常任幹事
一般社団法人臨床試験医師養成協議会理事
日本臨床検査同学院二級臨床検査士資格認定試験試験委員
日本血液学会評議員、専門医試験問題作成委員

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Awards (9)：

2018/02 - 東田修二:公益信託臨床検査医学研究振興基金「小酒井望賞」
2008 - 日本臨床検査医学会学会賞(生命科学賞)
2001 - 黒住医学研究振興財団第9回研究助成金
1996 - 平成7年度公益信託臨床病理学研究奨励金
1995 - 第11回井上研究奨励賞

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Association Membership(s) (9)：

American Society of Hematology , 日本癌学会 , 日本医療検査科学会 , 日本感染症学会 , 日本臨床微生物学会 , 日本検査血液学会 , 日本血液学会 , 日本内科学会 , 日本臨床検査医学会

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