Ito Hidenori

イトウヒデノリ | Ito Hidenori

Affiliation and department：
Job title：室長

Research field (5)： Neuroscience - general , Pharmacology , Pharmaceuticals - health and biochemistry , Cell biology , Molecular biology

Research keywords (9)：神経科学 , シナプス , 海馬 , 発達障害 , 低分子量Gタンパク質 , crystallin , phosphorylation , stress proteins , stress response

Research theme for competitive and other funds (28)：

2019 - 2022 Neurodevelopmental disorder related Rac signaling pathways control the neonatal development of the dentate gyrus
2016 - 2019 歯状回神経細胞の発達における知的障害・精神疾患関連Rhoシグナル伝達系の機能解明
2011 - 2015 統合失調症発症脆弱性因子dysbindin-1による細胞機能制御
2011 - 2012 Analyses of pathophysiology for molecules causing mental retardation
2009 - 2012 Septin functions and autistic spectrum disorder/pervasive developmental disorders during neuronal development

2009 - 2011 統合失調症関連分子dysbindin-1の性状機能解析

2007 - 2009 セプチン結合タンパク質の探索と性状・機能解析

2007 - 2009 Analysis of molecular and cellular targets in neurotoxicity of alternatives to ozone-depleting substances and establishment of biomarkers for the central nervous toxicity

2005 - 2007 セプチンの細胞内動態を制御する分子の探索と機能解析

2006 - 2007 Sept8をモデルとした新奇G蛋白質セプチンの性状・機能解析

2003 - 2005 低分子量分子シャペロンと相互作用する蛋白質の解析

2003 - 2004 Small Ubiquitin-related Modifier is Involved in Regulatory Mechanisms of DNA Repair and/or Gene Expression in Pancreatic Acinar Cells.

2001 - 2003 ユビキチン/プロテアソーム系とαBクリスタリンの細胞内動態の関連について

2003 - 2003 分子シャペロン、Hsp27とαBクリスタリンの細胞内蛋白質品質管理に果たす役割

2000 - 2003 Studies on α crystallin small molecular chaperones

2002 - 2002 分子シャペロン、Hsp27とαBクリスタリンの細胞内蛋白質品質管理に果たす役割

2002 - 2002 アグリソームの構成成分であるαBクリスタリンとHsp27の生理的・病理的意義

2001 - 2002 αBクリスタリンの神経組織蓄積機構の解明

2001 - 2002 Roles of Small Ubiquitin-related Modifier in Pancreatic Acinar Cells.

1999 - 2001 細胞内および動物組織におけるαBクリスタリンのリン酸化の生理的意義の解明

2001 - 2001 Aggresomeの構成成分であるリン酸化αBクリスタリンの生理的・病理的意義

2000 - 2000 脳の老化に伴って脳に沈着する分子シャペロンの生理的・病理的意義

2000 - 2000 神経組織での低分子量分子シャペロンのストレス応答と生理的意義

1999 - 1999 神経組織での低分子量分子シャペロンのストレス応答と生理的意義

1998 - 1998 神経障害時の低分子量分子シャペロンの応答と生理的意義

1998 - 1998 αBクリスタリンのリン酸化とその生理的意義

1994 - 1996 Research on the mammalian small stress protein family

Elucidation of physiological function of phosphorylated small heat shock proteins

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Papers (127)：

Masashi Nishikawa, Tohru Matsuki, Nanako Hamada, Atsuo Nakayama, Hidenori Ito, Koh-ichi Nagata. Expression analyses of WAC, a responsible gene for neurodevelopmental disorders, during mouse brain development. Medical Molecular Morphology. 2023
Rie Seyama, Masashi Nishikawa, Yuri Uchiyama, Keisuke Hamada, Yuka Yamamoto, Masahiro Takeda, Takanori Ochi, Monami Kishi, Toshifumi Suzuki, Kohei Hamanaka, et al. A missense variant at the RAC1-PAK1 binding site of RAC1 inactivates downstream signaling in VACTERL association. Scientific Reports. 2023. 13. 1
Naoki Goto, Masashi Nishikawa, Hidenori Ito, Mariko Noda, Nanako Hamada, Hidenori Tabata, Makoto Kinoshita, Koh-Ichi Nagata. Expression analyses of Rich2/Arhgap44, a Rho family GTPase-activating protein, during mouse brain development. Developmental neuroscience. 2023
Hidenori Tabata, Megumi Sasaki, Masakazu Agetsuma, Hitomi Sano, Yuki Hirota, Michio Miyajima, Kanehiro Hayashi, Takao Honda, Masashi Nishikawa, Yutaka Inaguma, et al. Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex. Nature Communications. 2022. 13. 1
Marcello Scala, Masashi Nishikawa, Hidenori Ito, Hidenori Tabata, Tayyaba Khan, Andrea Accogli, Laura Davids, Anna Ruiz, Pietro Chiurazzi, Gabriella Cericola, et al. Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes. Brain. 2022. 145. 9. 3308-3327

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MISC (29)：

Y. Mizutani, H. Ito, I. Iwamoto, R. Morishita, H. Kanoh, M. Seishima, K. Nagata. A septin, SEPT1, is involved in cell spreading of squamaous cell carcinoma DJM-1 cells. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012. 132. S46-S46
H. Ito, R. Morishita, T. Shinoda, I. Iwamoto, K. Sudo, K. Nagata. SCHIZOPHRENIA SUSCEPTIBILITY GENE, DYSBINDIN-1, REGULATES THE DENDRITIC SPINE FORMATION: EVIDENCE SUPPORTING NEURODEVELOPMENTAL HYPOTHESIS. JOURNAL OF NEUROCHEMISTRY. 2010. 115. 15-15
H. Ito, K. Atsuzawa, R. Morishita, N. Usuda, K. Sudo, I. Iwamoto, K. Mizutani, R. Katoh-Semba, Y. Nozawa, T. Asano, et al. Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin. (vol 108, pg 867, 2009). JOURNAL OF NEUROCHEMISTRY. 2009. 108. 6. 1621-1621
BANU Shameema. REVERSIBILITY OF THE ADVERSE EFFECTS OF 1-BROMOPROPANE EXPOSURE IN MALE RATS. 2007. 62. 2. 472-472
Ito Hidenori, Usuda Nobuteru, Atsuzawa Kimie, Iwamoto Ikuko, Sudo Kaori, Katoh-Semba Ritsuko, Mizutani Kosuke, Morishita Rika, Deguchi Takashi, Nozawa Yoshinori, et al. P2-19 Phosphorylation by MAP kinase of a Multi-Domain Adaptor Protein, Vinexin, in Neurons :. 2007. 48. 124-124

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Education (2)：

- 1994 Nagoya City University
- 1992 Nagoya City University Medicin

Professional career (1)：

博士(薬学) (名古屋市立大学)

Work history (4)：

2017/04 - 現在愛知県心身障害者コロニー発達障害研究所室長
2008 - Institute for Developmental Research, Aichi Human Service Center
1998 - Institute for Developmental Research, Aichi Human Service Center
1994 - Institute for Developmental Research, Aichi Human Service Center

Committee career (1)：

2017 - 現在日本臨床分子形態学会評議員

Association Membership(s) (2)：

THE JAPANESE SOCIETY FOR CLINICAL MOLECULAR MORPHOLOGY , 日本生化学会

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