Kira Junichi | Researcher Information

2022 - 2025 単一細胞RNA解析による多系統萎縮症増悪性ミクログリア亜群の同定と同細胞標的療法
2022 - 2025 毒性ターンAβ42含有エキソソームによるアルツハイマー病早期診断と病態伝搬の解明
2022 - 2025 Mechanisms and therapy of autoimmune nodopathy type central and peripheral demyelination by newly discovered anti-nodal antibodies
2022 - 2025 中枢神経炎症性疾患の治療を遺伝・免疫・血清学的指標を用いて最適化する方法の確立
2021 - 2024 グリアコネキシン低分子量イソフォーム発現エキソソームによる脱髄炎の悪化と治療開発

2020 - 2023 A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expression

2020 - 2023 活性化グリア細胞制御による進行性多発性硬化症および多系統萎縮症の画期的治療法開発

2020 - 2023 Novel therapy for spinal cord damage of neuromyelitis optica via regulation of BK channel

2019 - 2022 Challenges to the hypothesis that the blood-arachnoid barrier efflux transport systems function as central nervus system detoxification system

2019 - 2022 Elucidation of autoimmune mechanisms and developement of novel therapy for demyelinating diseases based on genetic and envrionmental risk factors and disease-specific anti-neural antibodies

2018 - 2021 Parent-of-origin effect in multiple sclerosis susceptibility

2016 - 2020 A Study of improving treatment efficiency of acute stroke care by revamping acute phase protocol

2017 - 2019 Establishment of world-premier pachymeningitis animal model and development of new therapeutic option targeting TGF-beta.

2016 - 2019 Elucidation of mechanisms for destruction and fixation of glia-syncytium in demyelinating diseases by whole-genome sequencing and immunohistochemical analysis.

2015 - 2018 Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange

2015 - 2018 Retro-element insertion polymorphism in pathogenic Th17 cells specific for multiple sclerosis and its action

2013 - 2018 Glial assembly:a new regulatory machinery of brain function and disorders

2015 - 2017 Induction of concentric demyelinating lesion in glia-specific connesin conditional deficient mice.

2013 - 2017 Elucidasion of functional contribution of glial dysturbances in pathomechanisms of demyelinating diseases and schizophrenia and development of new therapeutic options

2013 - 2016 Investigation of the role of TRPV4 in acute ischemic stroke

2013 - 2015 To generate and analyze new Parkinson's disease mice model with increased oxidative stress

2013 - 2015 connexin cytopathy in the pathogenesis of demyelinating disorders

2013 - 2014 Developing a cell transplantation therapy for chronic multiple sclerosis by using Schwann cells induced from mesenchymal stem cells

2011 - 2012 Connexin astrocytopathy in the pathogenesis of demyelination in concentric sclerosis and multiple sclerosis

2010 - 2012 The influence of genetic polymorphism on preoperative platelet function testing in patients undergoing Carotid Artery Stenting

2010 - 2012 Development of molecular targeted therapy of multiple sclerosis on the basis of membrane protein microarray analysis and gene interactions

2008 - 2009 軸索型ギラン・バレー症候群先行感染菌由来蛋白の軸索膜ポア形成による傷害とその治療

2006 - 2008 Role of IL-17 producing T cells in opticospinal multiple sclerosis

2006 - 2007 筋萎縮性側索硬化症に対するG-CSF療法の開発

2002 - 2007 多発性硬化症の神経免疫学的研究

2002 - 2007 Neuroimmunological study on multiple sclerosis

2005 - 2006 HLA class II polymorphism and worldwide susceptibility to optico-spinal multiple sclerosis.

2002 - 2004 Development and pharmacological analysis of therapeutic drugs for conformation diseases and prion diseases

2002 - 2003 Analysis of the effect with the, expanded CTG repeat for cell toxicity, especially tauopathy in the central nervous system in patietnt of myotonic dystrophy type 1 (DM 1)

2002 - 2003 Development of an animal model of opticospinal form of multiple sclerosis using the HLA-DP5 transgenic mice.

2002 - 2002 アトピー素因を伴う脊髄炎・ミエロパチーにおける疾患感受性遺伝子の検索

2001 - 2002 STUDY OF ALLERGIC REACTION IN PATHOGENESIS OF MYASTHENIA GRAVIS

2000 - 2002 Detection of prion infectivity of vibrinogen in human blood

2000 - 2001 Identification of a specific autoantigen in opticospinal form of multiple sclerosis based on the HLA-DPB1 binding motif

2000 - 2001 MOLECULAR AND PATHOLOGICAL ANALYSIS OF SPINAL CORD EOSINOPHILIC LESIONS IN ATOPIC MYELITIS

1999 - 2001 Analysis of TCR/HLA/ peptide interaction and investigation of etiology of autoimmune diseases

1999 - 2001 THE DIVESITY IN ANTIGEN RECOGNITION AND RESPONSE OF ANTIGEN-SPECIFIC HUMAN CD4^+ T-CELL CLONES

2000 - 2000 アトピー性疾患に伴う脊髄前角運動ニューロン傷害の発生機序に関する分子免疫学的研究

1999 - 2000 アジア型多発性硬化症特異的なHLA-DPB1*0501拘束性T細胞株の樹立と対応する脳自己抗原の同定

1998 - 2000 アストロサイト由来の自己反応性T細胞抑制因子の解明と遺伝子クローニング

1999 - 1999 HIV-1のヒト正常リンパ球ーの潜伏感染機構の解明

1999 - 1999 アトピー性皮膚炎自然発症マウスを用いたアトピー性脊髄炎動物モデルの作製

1998 - 1999 Establishment of a polyreactive T cell clone from Asian type multiple sclerosis patients and identification of the responsible antigens

1998 - 1999 Induction of chronic inflammatory myelopathy in rats infected with recombinant HTLV-I

1998 - 1998 日本人の自己免疫疾患に特有のHLAクラスII・自己抗原ペプチド複合体の解析

1998 - 1998 ダニ抗原特異的なアトピーを特徴とする脊髄炎におけるTh2タイプT細胞応答の解析

1996 - 1997 Analysis of T cell epitope in Asian type multiple sclerosis

1994 - 1994 HTLV-1に対するペプチドワクチンの開発

1993 - 1994 The presence of mutant HTLV-I in the central nervous system

1991 - 1992 神経親和性ヒトレトロウイルスによる神経障害機構の分子遺伝学的及び細胞生物学的解析

1988 - 1990 Study of Immunomechanisms in HTLV-I-Associated Myelopathy(HAM)

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Senri Ko, Ryo Yamasaki, Tasuku Okui, Wataru Shiraishi, Mitsuru Watanabe, Yu Hashimoto, Yuko Kobayakawa, Susumu Kusunoki, Jun-ichi Kira, Noriko Isobe. A nationwide survey of facial onset sensory and motor neuronopathy in Japan. Journal of the Neurological Sciences. 2024. 122957-122957
Yuri Mizuno, Taira Uehara, Yuri Nakamura, Toshiki Okadome, Takahiko Mukaino, Kishin Koh, Yoshihisa Takiyama, Takashi Kanbayashi, Noriko Isobe, Jun-Ichi Kira, et al. A case of monozygotic twins with hereditary spastic paraplegia type 4 and epilepsy, of whom only one developed narcolepsy type 1. Journal of sleep research. 2023. e14102
Satoshi Nagata, Ryo Yamasaki, Ezgi Ozdemir Takase, Kotaro Iida, Mitsuru Watanabe, Katsuhisa Masaki, Marion Heleen Cathérine Wijering, Hiroo Yamaguchi, Jun-Ichi Kira, Noriko Isobe. Iguratimod Ameliorates the Severity of Secondary Progressive Multiple Sclerosis in Model Mice by Directly Inhibiting IL-6 Production and Th17 Cell Migration via Mitigation of Glial Inflammation. Biology. 2023. 12. 9
原田雅也, 眞崎勝久, 松瀬大, 山口浩雄, 西村由宇慈, 高瀬オズデミールエズギ, 田中栄蔵, 田中辰典, 山崎亮, 竹内英之, et al. 中枢神経作用コネキシン阻害薬による多系統萎縮症小脳型モデルマウスの治療. 神経免疫学. 2023. 28. 1. 191-191
林信太郎, 山崎亮, 小早川優子, 吉良潤一, 磯部紀子. 活性化ミクログリアが産生する蛋白に着目した運動神経細胞変性相関因子の同定と診断バイオマーカーの探求. 神経免疫学. 2023. 28. 1. 206-206

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磯部紀子, 渡邉充, 新野正明, 中島一郎, 松下拓也, 酒井康成, 中原仁, 河内泉, 河内泉, 越智博文, et al. 神経免疫疾患の診断・重症度分類・ガイドラインの妥当性検証・改定と全国調査による患者QOLの改善の検証第5回全国調査からみた多発性硬化症の重症度に寄与する因子の検討. 神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証令和3年度総括・分担研究報告書(Web). 2022
新野正明, 福元尚子, 奥野龍禎, 三條伸夫, 深浦彦彰, 森雅裕, 大橋高志, 竹内英之, 清水優子, 藤盛寿一, et al. 日本人多発性硬化症患者における認知機能とQOL,疲労,抑うつとの相関. 日本神経学会学術大会プログラム・抄録集. 2022. 63rd
吉良潤一, 吉良潤一, 磯部紀子, 渡邉充, 松下拓也, 福元尚子, 林史恵, 新野正明, 宮崎雄生, 中島一郎, et al. 神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証第5回多発性硬化症・視神経脊髄炎全国臨床疫学調査結果第2報. 神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証令和2年度総括・分担研究報告書(Web). 2021
岩永育貴, 齋藤万有, 迫田礼子, 柳原由記, 中村優理, 山下謙一郎, 飛松省三, 緒方英紀, 吉良潤一. 抗Contactin-1抗体陽性CIDPの一例. 臨床神経学(Web). 2021. 61. 11
Jun-ichi Kira, Noriko Isobe, Masaaki Niino, Takuya Matsushita, Yuri Nakamura, Ichiro Nakashima, Mitsuru Watanabe, Yasunari Sakai, Ayako Sakoda, Jin Nakahara, et al. Continued Increase of Multiple Sclerosis and Neuromyelitis Optica in Japan: Updates from the 5th Nationwide Survey. ANNALS OF NEUROLOGY. 2020. 88. S199-S200

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神経内科研修ノート : neurology
診断と治療社 2015 ISBN:9784787820792
MS FRONTIER 3ー2-多発性硬化症の先端情報誌座談会多発性硬化症の環境因子をめぐって
メディカルレビュー社 2014 ISBN:4779213878
今日の神経疾患治療指針第2版 (今日の治療指針シリーズ)
医学書院 2013 ISBN:4260016210
今日の神経疾患治療指針
医学書院 2013 ISBN:9784260016216
最新アプローチ多発性硬化症と視神経脊髄炎 (アクチュアル脳・神経疾患の臨床)
中山書店 2012 ISBN:4521734413

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