Rchr
J-GLOBAL ID：200901097708378870   Update date: Jan. 30, 2024

Hosoda Nao

ホソダ ナオ | Hosoda Nao
Affiliation and department：
Nagoya City University Graduate School of Pharmaceutical Sciences Department of Biological Chemistry

About Nagoya City University Graduate School of Pharmaceutical Sciences Department of Biological Chemistry


Homepage URL  (1)： http://www.phar.nagoya-cu.ac.jp/resarch_course/res_course12.html
Research field  (1)： Functional biochemistry
Research keywords  (4)： 翻訳 ,  mRNA ,  遺伝子疾患 ,  ナンセンス変異
Research theme for competitive and other funds  (12)：
  • 2021 - 2025 外来性ウイルスRNAを分解する生体防御機構の全容解明
  • 2019 - 2022 翻訳終結因子eRF3のプロセシング異常がもたらす新しい癌発症メカニズム
  • 2017 - 2021 Mechanism of gene expression by cytoplasmic polyadenylation
  • 2017 - 2019 Development of mRNA stabilization technology for mRNA therapeutics
  • 2014 - 2017 Quality control mechanisms for aberrant mRNA that emerges under stress conditions
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Papers (35)：
  • Koichi Ogami, Yuka Oishi, Kentaro Sakamoto, Mayu Okumura, Ryota Yamagishi, Takumi Inoue, Masaya Hibino, Takuto Nogimori, Natsumi Yamaguchi, Kazuya Furutachi, et al. mTOR- and LARP1-dependent regulation of TOP mRNA poly(A) tail and ribosome loading. Cell Reports. 2022. 41. 4. 111548-111548
  • Takeru Sagae, Mariko Yokogawa, Ryoichi Sawazaki, Yuichiro Ishii, Nao Hosoda, Shin-Ichi Hoshino, Shunsuke Imai, Ichio Shimada, Masanori Osawa. Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail. The Journal of biological chemistry. 2022. 298. 5. 101844-101844
  • Hiroto Inagaki, Nao Hosoda, Shin-ichi Hoshino. DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery. Biochemical and Biophysical Research Communications. 2021. 553. 9-16
  • Hiroto Inagaki, Nao Hosoda, Hitomi Tsuiji, Shin-Ichi Hoshino. Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation. The Journal of biological chemistry. 2020. 295. 47. 15810-15825
  • Takuto Nogimori, Koichi Ogami, Yuka Oishi, Ryoya Goda, Nao Hosoda, Yoshiaki Kitamura, Yukio Kitade, Shin-Ichi Hoshino. ABCE1 Acts as a Positive Regulator of Exogenous RNA Decay. Viruses. 2020. 12. 2
ｍore...
MISC (4)：
Patents (4)：
Education (2)：
  • 1997 - 2002 東京大学大学院 薬学系研究科 機能薬学専攻
  • - 1997 The University of Tokyo
Professional career (1)：
  • 東京大学薬学系研究科/博士(薬学)
Work history (6)：
  • 2019/06 - 現在 Nagoya City University
  • 2011/04 - 2019/05 Nagoya City University Graduate School of Pharmaceutical Sciences
  • 2007/04 - 2011/03 Nagoya City University Graduate School of Pharmaceutical Sciences
  • 2006/06 - 2007/03 Nagoya City University Graduate School of Pharmaceutical Sciences
  • 2004/08 - 2006/05 米国ロチェスター大学医学部歯学部 博士研究員
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