Kazunori Aoki

アオキカズノリ | Kazunori Aoki

Affiliation and department：
Job title： Chief

Research field (3)： Gastroenterology , Immunology , Medical biochemistry

Research keywords (9)：免疫細胞ネットワーク , 免疫 , ベクター , 遺伝子治療 , がん , Immunology , gene therapy , pancreas , cancer

Research theme for competitive and other funds (13)：

2022 - 2025 術後せん妄発症を制御する免疫ランドスケープの解明
2021 - 2024 膵がんに特徴的なCAFとTreg相互作用の遮断に基づく免疫抑制環境の解除
2021 - 2024 Development study on pathological predictive biomarkers for cancer treatment
2019 - 2023 Clinical application of boron-conjugated adenovirus vector for neutron capture therapy
2018 - 2021 外科的がん切除後のデクスメデトミジンによる鎮静に不応な重症せん妄発症を予測するバイオマーカーの開発

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Papers (68)：

Panyawut Sri-iesaranusorn, Ryoichi Sadahiro, Syo Murakami, Saho Wada, Ken Shimizu, Teruhiko Yoshida, Kazunori Aoki, Yasuhito Uezono, Hiromichi Matsuoka, Kazushi Ikeda, et al. Data-driven categorization of postoperative delirium symptoms using unsupervised machine learning. Frontiers in Psychiatry. 2023. 14
Masato Karayama, Yukihiro Mizoguchi, Yusuke Inoue, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, et al. Association between increased peripheral blood CD86-positive plasmacytoid dendritic cells and immune-related adverse events in patients with non-small cell lung cancer. Glob Health Med. 2022. 4. 6. 301-308
Ayumu Arakawa, Hitoshi Ichikawa, Takashi Kubo, Noriko Motoi, Tadashi Kumamoto, Miho Nakajima, Kan Yonemori, Emi Noguchi, Kuniko Sunami, Kouya Shiraishi, et al. Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants. The New England journal of medicine. 2021. 384. 1. 42-50
Shun Yamamoto, Ken Kato, Hiroyuki Daiko, Takashi Kojima, Hiroki Hara, Tetsuya Abe, Yasuhiro Tsubosa, Kengo Nagashima, Kazunori Aoki, Yukihiro Mizoguchi, et al. Feasibility study of nivolumab as neoadjuvant chemotherapy for locally esophageal carcinoma: FRONTiER (JCOG1804E). Future Oncology. 2020. 16. 19. In press-1357
Lankadasari MB, Aparna JS, Mohammed S, James S, Aoki K, Binu VS, Nair S, Harikumar KB. Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine. Theranostics. 2018. 8. 14. 3824-3840

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MISC (38)：

Yuki Yamamoto, Masaki Nagasato, Teruhiko Yoshida, Kazunori Aoki. Recent advances in genetic modification of adenovirus vectors for cancer treatment. CANCER SCIENCE. 2017. 108. 5. 831-837
Amanda Oliveira Salzwedel, Christopher LaRocca, Joohee Han, Kazunori Aoki, Julia Davydova, Masato Yamamoto. Oncolytic Adenovirus Expressing IFN-alpha synergistically potentiates chemotherapy, radiation, and chemoradiation in pancreatic cancer cells. FASEB JOURNAL. 2017. 31
青木一教, 上田亮介, 鳴海兼太, 橋本尚佳, 猪野義典, 平岡伸介, 庄司広和, 濱口哲弥, 多田耕平, 北野滋久, et al. MDSC除去は化学療法による抗腫瘍免疫を増強する. 日本癌学会総会記事. 2015. 74回. E-1230
Tomoyoshi Aoyagi, Dorit Avini, Masayuki Nagahashi, Akimitsu Yamada, Krista P. Terracina, Wei-Ching Huang, Kazunori Aoki, Yasunori Matsumoto, Sarah Spiegel, Hisahiro Matsubara, et al. FTY720 suppressed CT26 murine colon cancer peritoneal carcinomatosis progression by decreasing tumor associated macrophages and TNF-alpha. CANCER RESEARCH. 2015. 75
Ryosuke Ueda, Kenta Narumi, Reina Miyakawa, Hisayoshi Hashimoto, Kazunori Aoki. Natural Killer Cell-Mediated Antitumor Effect of Syngeneic Hematopoietic Stem Cell Transplantation. BLOOD. 2014. 124. 21

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Professional career (1)：

Medicine

Work history (10)：

2018/04 - 現在 National Cancer Center, Research Institute Deputy Director
2016/11 - 現在 National Cancer Center, Research Institute Department of Immune Medicine Chief
2014/08 - 2016/10 国立がん研究センター研究所分子細胞治療研究分野分野長
2010/10 - 2014/08 国立がん研究センター研究所遺伝子免疫細胞治療研究分野分野長
1999/06 - 2010/09 国立がん研究センター研究所がん宿主免疫研究室室長

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Committee career (2)：

日本遺伝子治療学会評議員
日本癌学会評議員

Association Membership(s) (7)：

American Society of Clinical Oncology , American Association of Cancer Research , American Society of Gene Therapy , 日本分子生物学会 , 日本内科学会 , 日本遺伝子治療学会 , 日本癌学会

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