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J-GLOBAL ID：200901099507789034   Update date: Apr. 17, 2024

Makishima Makoto

マキシマ マコト | Makishima Makoto
Affiliation and department：
Nihon University School of Medicine Department of Medicine -

About Nihon University School of Medicine Department of Medicine -


Job title： Professor
Research field  (4)： Pharmacology ,  Molecular biology ,  Pathobiochemistry ,  Medical biochemistry
Research keywords  (13)： receptor ,  xenobiotic ,  lipid ,  transcription factor ,  metabolism regulation ,  leukemia ,  cancer ,  bile acid ,  cholesterol ,  metabolism ,  gene ,  transcription ,  nuclear receptor
Research theme for competitive and other funds  (9)：
  • 2022 - 2026 The role of vitamin D receptor of hepatic immune cells in the pathogenesis of nonviral liver disease
  • 2016 - 2020 Regulation of intestinal and hepatic immunity by vitamin D receptor signaling
  • 2014 - 2016 The relationship between vitamin D signaling and bile acid metabolism in obesity mice.
  • 2013 - 2016 Regulation of intestinal and hepatic immunity and metabolism by vitamin D receptor
  • 2011 - 2012 Clarify the meaning of Magnolia obovata in Kampo medicine on nuclear receptor activation.
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Papers (324)：
  • Sumie Ohni, Hiromi Yamaguchi, Yukari Hirotani, Yoko Nakanishi, Yutaka Midorikawa, Masahiko Sugitani, Tomohiro Nakayama, Makoto Makishima, Mariko Esumi. Complex phenotypic heterogeneity of combined hepatocellular-cholangiocarcinoma with a homogenous TERT promoter mutation: case study and mini-review of the literature. American Journal of Translational Research. 2024. 16. 2. 690-699
  • Sayuri Takahashi, Ichiro Takada, Kenichi Hashimoto, Atsushi Yokoyama, Tohru Nakagawa, Makoto Makishima, Haruki Kume. ESS2 controls prostate cancer progression through recruitment of chromodomain helicase DNA binding protein 1. Scientific Reports. 2023. 13. 1
  • Kazuki Maekawa, Michiyasu Ishizawa, Takashi Ikawa, Hironao Sajiki, Taro Matsumoto, Hiroaki Tokiwa, Makoto Makishima, Sachiko Yamada. Syntheses of 25-Adamantyl-25-alkyl-2-methylidene-1α,25-dihydroxyvitamin D3 Derivatives with Structure-Function Studies of Antagonistic and Agonistic Active Vitamin D Analogs. Biomolecules. 2023. 13. 7. 1082-1082
  • Hitomi Kubota, Michiyasu Ishizawa, Makoto Kodama, Yoshihiro Nagase, Shigeaki Kato, Makoto Makishima, and Kenichi Sakurai. Vitamin D receptor mediates attenuating effect of lithocholic acid on dextran sulfate sodium induced colitis in mice. International Journal of Molecular Sciences. 2023. 24. 4. 3517
  • Xiaoyan Li, Lijia Guo, Fuyuki Sato, Toshiyasu Kitayama, Nitesh Tewari, Makoto Makishima, Nobushiro Hamada, Yi Liu, and Ujjal K Bhawal. Dec2 negatively regulates bone resorption in periodontitis. Journal of Periodontal Research. 2022. 57. 5. 1056-1069
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MISC (68)：
  • 阿部 百合子, 山口 裕美, Gonzalez Duarte Ramiro Jose, 高田 伊知郎, Qin Xian-Yang, 小嶋 聡一, 高山 忠利, 槇島 誠, 江角 眞理子. 早期再発肝細胞癌に発現亢進するトランスグルタミナーゼ2の解析. 日大医学雑誌. 2020. 79. 1. 54-54
  • Ichiro Takada, and Makoto Makishima. Peroxisome proliferator-activated receptor agonists and antagonists: a patent review (2014-present). Expert Opinion on Therapeutic Patents. 2020. 30. 1. 1-13
  • 渡邉 将貴, 中山 真理子[中村], 瀧奥 真歩, 山田 翔也, 高村 祐太, 藤原 美智子, 槙島 誠, 川崎 真由, 本山 智晴, 伊藤 創平, et al. レチノイドX受容体ホモ二量体選択的アンタゴニストCBTF-EEの創出. ビタミン. 2019. 93. 4. 211-211
  • 安達慶太、櫻井健一、窪田仁美、鈴木佑奈、鈴木周平、槇島誠、越永從道. 年齢を考慮した高齢者男性乳癌の治療経験. 癌と化学療法. 2019. 46. 2. 309-311
  • 安達慶太、櫻井健一、窪田仁美、鈴木佑奈、鈴木周平、槇島誠、越永從道. 頸部リンパ節腫脹を契機に発見された高齢者進行乳癌の1 例. 癌と化学療法. 2019. 46. 2. 312-314
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Patents (8)：
  • パーシャルアゴニスト活性を持つ新規ビタミンD受容体モジュレーター
  • 白血病治療薬
  • 白血病治療薬
  • 9-シス-レチノイン酸-α-トコフェロールエステルを含有する白血病治療薬
  • アディポネクチンプロモーターおよびその用途
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Books (10)：
  • Bile acid-derived vitamin D receptor ligands. In: Feldman D (ed), Vitamin D, fourth edition
    Academic Press 2017 ISBN:9780128099636
  • Cooperative regulation of expression of cytochrome P450 enzymes by aryl hydrocarbon receptor and vitamin D receptor. In: Yamasaki H (ed), Fifty Years of Cytochrome P450 Research
    Springer Japan 2014 ISBN:9784431549918
  • The bile acid derivative lithocholic acid acetate and lithocholic acid propionate are functionally selective vitamin D receptor ligands. In: Feldman D., Pike JW, and Adams JS (eds), Vitamin D, third edition
    Academic Press 2011 ISBN:9780123870346
  • Nuclear receptors sense bile acid metabolism: A hormonal action of bile acids. In: Morikawa K, Tate S (eds), Functional and Structural Biology on the Lipo-network
    Transworld Research Network 2006 ISBN:8178952327
  • 核内レセプターによるコレステロール胆汁酸代謝調節. 食習慣を監視する分子メカニズム. 荒川泰行(編) 消化器病学の進歩 2005 - モノグラフ - 肝・胆・膵 編
    日本消化器病学会 2005
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Lectures and oral presentations  (459)：
  • Regulation of hepatic immune cells by the oxysterol receptors, LXRs
    (The 21st IRCM Symposium on The Dynamics and Development of Normal and Malignant Hematopoietic Stem Cells 2024)
  • リトコール酸のマウス大腸炎抑制効果におけるビタミンD受容体の役割
    (第46回日本分子生物学会年会 2023)
  • 摂食同調後の給餌によるFGF15発現量低下機構の解明
    (第44回胆汁酸研究会 2023)
  • 肝臓免疫細胞におけるVDR依存性の機能発現の解析
    (第377回脂溶性ビタミン総合研究委員会 2023)
  • レチノイドX受容体(RXR)を蛍光標識するNBD結合プローブに関する研究
    (日本レチノイド研究会第34回学術集会 2023)
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Education (1)：
  • - 1987 National Defense Medical College Faculty of Medicine
Work history (8)：
  • 2004/04 - 現在 Professor, Department of Biochemistry, Nihon University School of Medicine
  • 2002/04 - 2004/03 Associate Professor, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University
  • 1998/03 - 2002/03 Associate, Howard Hughes Medical Institute and University of Texas Southwestern Medical Center
  • 1996/04 - 1998/03 Chief-in-Physician, Saitama Comprehensive Mental Health Center
  • 1993/08 - 1996/03 Staff Physician, Saitama Comprehensive Mental Health Center
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Committee career (7)：
  • 2010/11 - 現在 胆汁酸研究会 世話人
  • 2010/06 - 現在 日本ビタミン学会 評議員
  • 2008/11 - 現在 日本レチノイド研究会 幹事
  • 2006/04 - 現在 脂溶性ビタミン総合研究委員会 委員
  • 2005/04 - 現在 日本薬理学会 学術評議員
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Association Membership(s) (14)：
胆汁酸研究会 ,  日本ビタミン学会 ,  日本レチノイド研究会 ,  The Japanese Society of Internal Medicine ,  The Japanese Society of Hematology ,  The Japanese Cancer Association ,  The Japanese Pharmacological Society ,  The Japanese Biochemical Society ,  The Molecular Biology Society of Japan ,  The American Society for Biochemistry and Molecular Biology ,  The Endocrine Society ,  American Society of Microbiology ,  脂溶性ビタミン総合研究委員会 ,  日本内分泌学会
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