Art

J-GLOBAL ID：200902001837470240   Reference number：90A0562577

Evaluation of the neuroprotective action of WEB 1881 FU on hypoglycemia/hypoxia-induced neuronal damage using rat striatal slices.

ラット線条体スライスを使った低血糖/酸素欠乏誘発神経障害に及ぼすWEB1881FUの神経保護活性の評価

Author (5)： KOIZUMI S (Kyushu Univ., Fukuoka, JPN) ,  KATAOKA Y (Nagasaki Univ. School of Medicine, Nagasaki, JPN) ,  SHIGEMATSU K (Nagasaki Univ. School of Medicine, Nagasaki, JPN) ,  NIWA M (Nagasaki Univ. School of Medicine, Nagasaki, JPN) ,  UEKI S (Kyushu Univ., Fukuoka, JPN)
Material： Japanese Journal of Pharmacology  (Jpn J Pharmacol)
Volume： 53  Issue： 2  Page： 175-183  Publication year： Jun. 1990 
JST Material Number： G0813A  ISSN： 0021-5198  CODEN： JJPAA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： brain metabolic stimulant ,...
Semi thesaurus term： WEB1881FU ,...

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JST classification (1)： Basic research of other drugs acting on central nervous system  (GW03120U)

Reference (23)：

• 1) Benveniste, H., Drejer, J., Schousboe, A. and Diemer, N.H.: Elevation of extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43, 1369-1374 (1984)
• 2) Engelsen, B., Westerberg, E., Fonnum, F. and Wieloch, T.: Effect of insulin-induced hypoglycemia on the concentrations of glutamate and related amino acids and energy metabolites in the intact and decorticated rat neostriatum. J. Neurochem. 47, 1634-1641 (1986)
• 3) Simon, R.P., Swan, J.H., Griffith, T. and Meldrum, B.S.: Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Science 226, 850-852 (1984)
• 4) Wieloch, T.: Hypoglycemia-induced neuronal damage prevented by N-methyl-D-aspartate anagonist. Science 230, 681-683 (1985)
• 5) Kumakura, K., Ohara, M. and Sato, G.P.: Realtime monitoring of the secretory function of cultured adrenal chromaffin cells. J. Neurochem. 50, 1765-1768 (1986)

Terms in the title (10)： ラット ,  線条体 ,  スライス ,  低血糖 ,  酸素欠乏 ,  誘発 ,  神経障害 ,  神経 ,  活性 ,  評価