Art

J-GLOBAL ID：200902001911690975   Reference number：87A0057262

Subjective effects of tizanidine (DS103-282), a centrally acting muscle relaxant in healthy volunteers. Double blind comparative study vs. diazepam and placebo.

中枢性筋弛緩薬Tizanidine(DS103-282)の健常人における自覚効果の検討 Diazepam,Placeboとの二重盲検比較試験

Author (3)： YANAGITA TOMOJI (実験動物中研 前臨床医研) ,  YAMAMURA HIDEO (東京専売病院) ,  IGARASHI SHOGO (東京専売病院)
Material： 臨床薬理  (Japanese Journal of Clinical Pharmacology and Therapeutics)
Volume： 17  Issue： 3  Page： 509-525  Publication year： Sep. 1986 
JST Material Number： F0384B  ISSN： 0388-1601  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： muscle relaxant ,...
Semi thesaurus term： benzodiazepine tranquilizer ,...

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JST classification (1)： Clinical applications of antiepileptics and anticonvulsants  (GW03070O)

Reference (24)：

• 1) Davies, J.: Selective depression of synaptic transmission of spinal neurones in the cat by a new centrally acting muscle relaxant, 5-chlro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-ben-zothiodazole (DS 103-282). Br. J. Pharmac., 76: 473-481 (1982).
• 2) Sayers, A. C., Burki, H. R. and Eichenberger, E.: The pharmacology of 5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-benzothiadiazole (DS 103-282) a novel myotonolytic agent. Arzneim.-Forpch./Drug Res., 30: 793-803 (1980).
• 3) Coward, D. M.: Selective muscle relaxant properties of tizanidine and an examination of its mode of action. Triangle, 20: 151-158 (1981).
• 4) Brasgtad, A. and Blikra, G.: Evaluation of a new skeletal muscle relaxant in the treatment of low back pain. Curr. Ther. Res., 26: 39-43 (1979).
• 5) Lepisto, P.: A comparative trial of DS 103-282 and placebo in the treatment of acute skeletal muscle spasms due to disorders of the back. Curr. Ther. Res., 26: 454-459 (1979).

Terms in the title (4)： 中枢性筋弛緩薬 ,  健常人 ,  自覚 ,  二重盲検比較試験