Art

J-GLOBAL ID：200902002059239001   Reference number：91A0230452

Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.

HMG-CoAレダクターゼ阻害薬における組織選択性と親油性の関係

Author (9)： ROTH B D (Warner-Lambert Co., Michigan) ,  BOCAN T M A (Warner-Lambert Co., Michigan) ,  BLANKLEY C J (Warner-Lambert Co., Michigan) ,  CHUCHOLOWSKI A W (Warner-Lambert Co., Michigan) ,  CREGER P L (Warner-Lambert Co., Michigan) ,  CRESWELL M W (Warner-Lambert Co., Michigan) ,  FERGUSON E (Warner-Lambert Co., Michigan) ,  NEWTON R S (Warner-Lambert Co., Michigan) ,  WILSON M W (Warner-Lambert Co., Michigan)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 34  Issue： 1  Page： 463-466  Publication year： Jan. 1991 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： HMG-CoA reductase ,...
Semi thesaurus term： ロバスタチン ,...

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JST classification (1)： Basic research of drugs acting on lipid metabolism  (GW13040M)

Substance index (15)： Lovastatin ,  Pravastatin ,  Fluvastatin ,  BMY-21950 ,  (3R,5R)-3,5-Dihydroxy-7-[3-phenyl-4-phenylcarbamoyl-2-(4-fluorophenyl)-5-isopropyl-1H-pyrrol-1-yl]heptanoic acid sodium salt ,  (3R,5R)-3,5-Dihydroxy-7-[3,4-dibromo-2-(4-fluorophenyl)-5-isopropyl-1H-pyrrol-1-yl]heptanoic acid sodium salt ,  SDZ-63370 ,  (3R,5S,6E)-3,5-Dihydroxy-7-[5-(4-fluorophenyl)-3-isopropyl-1-(2-pyridinyl)-1H-pyrazol-4-yl]-6-heptenoic acid sodium salt ,  (3R,5S,6E)-3,5-Dihydroxy-7-[5-(4-fluorophenyl)-3-isopropyl-1-(2-pyrazinyl)-1H-pyrazol-4-yl]-6-heptenoic acid sodium salt ,  (3R,5S,6E)-3,5-Dihydroxy-7-[4-(4-fluorophenyl)-2-isopropyl-6-methyl-3-pyridinyl]-6-heptenoic acid sodium salt ,  4-(4-Fluorophenyl)-3-[(1E,3S,5R)-3,5-dihydroxy-6-sodiooxycarbonyl-1-hexenyl]-2-isopropyl-6-methylpyridine 1-oxide ,  HOE-708 ,  (3R,5S,6E)-3,5-Dihydroxy-7-[6-chloro-4-(4-fluorophenyl)-2-isopropyl-3-quinolinyl]-6-heptenoic acid sodium salt ,  (3R,5S)-3,5-Dihydroxy-6-(2-cycloheptyl-4,6-dimethylphenoxy)hexanoic acid sodium salt ,  (3R,5S)-3,5-Dihydroxy-6-[2-(4-fluorophenyl)-6-isopropyl-3-(4-methylphenyl)phenoxy]hexanoic acid sodium salt

Terms in the title (3)： HMG-CoAレダクターゼ阻害薬 ,  組織選択性 ,  親油性