Art

J-GLOBAL ID：200902015499868153   Reference number：88A0087869

Trimethadione metabolism in patients with normal liver and in patients with chronic liver disease.

正常肝と慢性肝疾患の患者におけるトリメタジオンの代謝

Author (5)： TANAKA E (Univ. Tsukuba, Ibaraki, JPN) ,  ISHIKAWA A (Univ. Tsukuba, Ibaraki, JPN) ,  ONO A (Univ. Tsukuba, Ibaraki, JPN) ,  OKAMURA T (Tsukuba Gakuen Hospital, Ibaraki, JPN, Ibaraki-ken, JPN) ,  MISAWA S (Univ. Tsukuba, Ibaraki, JPN)
Material： Journal of Pharmacobio-Dynamics  (J Pharmacobio Dyn)
Volume： 10  Issue： 9  Page： 499-502  Publication year： Sep. 1987 
JST Material Number： S0989A  ISSN： 0386-846X  CODEN： JOPHDQ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： drug metabolism ,...
Semi thesaurus term： chronic disease ,...

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JST classification (2)： Clinical applications of antiepileptics and anticonvulsants  (GW03070O) ,  Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G)

Reference (14)：

• 1) M. Black: Liver disease and drug therapy, Med. Clin. North. Am., 58, 1051-1057 (1974).
• 2) G. R. Wilkinson and S. Schenker: Effects of liver disease on drug disposition in man, Biochem. Pharmacol., 25, 2675-2681 (1976).
• 3) E. Tanaka, I. Ishikawa, A. Ono, T. Okamura, S. Kobayashi, H. Yasuhara and S. Misawa: Trimethadione tolerance tests for evaluation of functional reserve of the liver in patients with liver cirrhosis and esophageal varices, J. Pharmacobio-Dyn., 9, 298-303 (1986).
• 4) E. Tanaka and S. Misawa: Simultaneous determination of serum trimethadione and its metabolite by gas chromatography, J. Chrmatogr., 413, 376-378 (1987).
• 5) C. D. Withrow: Trimethadione, "Antiepileptic Drugs," ed. by D. M. Wood, J. K. Penry and C. E. Pippenger, Raven Press, New York, 1982.

Terms in the title (5)： 肝 ,  慢性肝疾患 ,  患者 ,  トリメタジオン ,  代謝