Chemical modification of anthracycline antibiotics. I. Demethoxycarbonylation, 10-epimerization and 4-o-methylation of aclacinomycin A.

TANAKA H; YOSHIOKA T; SHIMAUCHI Y; MATSUZAWA Y; OKI T; INUI T

Art

J-GLOBAL ID：200902015684381406 Reference number：81A0038164

Chemical modification of anthracycline antibiotics. I. Demethoxycarbonylation, 10-epimerization and 4-o-methylation of aclacinomycin A.

アントラサイクリン抗生物質の化学修飾 I アクラシノマイシンAのデメトキシカルボニル化,10-エピマー化および4-o-メチル化

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Material：
Volume： 33 Issue： 11 Page： 1323-1330 Publication year： Nov. 1980
JST Material Number： G0489A ISSN： 0021-8820 Document type： Article
Article type：原著論文 Country of issue： Japan (JPN) Language： ENGLISH (EN)

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Basic research of antitumor(=antineoplastic)antibiotics , Structure-activity relationship of drugs

Reference (14)：

1) OKI, T.; Y. MATSUZAWA, A. YOSHIMOTO, K. NUMATA, I. KITAMURA, S. HORI, A. TAKAMATSU, H. UMEZAWA, M. ISHIZUKA, H. SUDA, M. HAMADA & T. TAKEUCHI: New antitumor antibiotics, aclacinomycins A and B. J. Antibiotics 28: 830-834, 1975
2) HORI, S.; M. SHIRAI, S. HIRANO, T. OKI, T. INUI, S. TSUKAGOSHI, M. ISHIZUKA, T . TAKEUCHI & H. UMEZAWA:Antitumor activity of new anthracycline antibiotics, aclacinomycin A and its analogs, and their toxicity. Gann 68: 685-690, 1977
3) OKI, T.; et al.: Recent results in Cancer Reserch, in press
4) OKI, T.; N. SHIBAMOTO, Y. MATSUZAWA, T. OGASAWARA, A. YOSHIMOTO, I. KITAMURA, T. INUI, H. NAGANAWA, T. TAKEUCHI & H. UMEZAWA: Production of nineteen anthracyclic compounds by Streptonlyces galilaeus MA144 M1. J. Antibiotics 30: 683-687,1977
5) OKI, T.; I. KITAMURA, A. YOSHIMOTO, Y. MATSUZAWA, N. SHIBAMOTO, T. OGASAWARA, T. INUI, A. TAKAMATSU, T. TAKEUCHI, T. MASUDA, M. HAMADA, M. ISHIZUKA, T. SAWA & H. UMEZAWA: Antitumor anthracyclinc antibiotics, aclacinomycin A and analogues. I. Taxonomy, production, isolation and physicochemical properties. J. Antibiotics 32: 791-800, 1979

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