Art

J-GLOBAL ID：200902023127512304   Reference number：83A0095263

Quaternary heterocyclylamino β-lactams. III. The mode of action of L-640,876 and the effect of NaCl on membrane permeability and binding.

四部分から成るヘテロ環アミノβ-ラクタム III L-640,876の作用機作および膜透過と結合に及ぼすNaClの影響

Author (4)： KOUPAL L R (Merck, New Jersey) ,  PELAK B A (Merck, New Jersey) ,  CASSIDY P J (Merck, New Jersey) ,  GADEBUSCH H H (Merck, New Jersey)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 36  Issue： 1  Page： 54-63  Publication year： Jan. 1983 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： cephalosporins ,...
Semi thesaurus term： MIC(concentration) ,...

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JST classification (1)： Basic research of antibiotics acting on pathogenic organisms  (GX05020C)

Reference (28)：

• 1) HANNAH, J.; C. R. JOHNSON, A. F. WAGNER & E. WALTON : Quaternary heterocyclylamino β-lactams : A generic alternative to the classical aminoacyl side chain. J. Med. Chem. 25 : 457-469, 1982
• 2) KOUPAL, L. R.; B. WEISSBERGER, D. L. SHUNGU, E. WEINBERG & H. H. GADEBUSCH : Quaternary hetero-cyclylamino β-lactams. II. The in vitro antibacterial properties of L-640,876, a new type of β-lactam antibiotic. J. Antibiotics 36 : 47-53, 1983
• 3) TYBRING, L. & N. H. MELCHIOR : Mecillinam (FL 1060), a 6β-amidinopenicillanic acid derivative : Bactericidal action and synergy in vitro. Antimicrob. Agents Chemother. 8 : 271-276, 1975
• 4) NEU, H.: Mecillinam, a novel penicillanic acid derivative with unusual activity against Gram-negative bacteria. Antimicrob. Agents Chemother. 9 : 793-799, 1976
• 5) GREENWOOD, D. & F. O'GRADY : FL 1060 : A new beta-lactam antibiotic with novel properties. J. Clin. Path. 26 : 1-6, 1973

Terms in the title (5)： ヘテロ環 ,  β-ラクタム ,  作用機作 ,  膜透過 ,  NaCl