Art

J-GLOBAL ID：200902131011117901   Reference number：00A0398925

Synthesis of Enantiomerically Pure (+)- and (-)-18-Methoxycoronaridine Hydrochloride and Their Preliminary Assessment as Anti-Addictive Agents.

エナンチオマ的に純粋な(+)-及び(-)-18-メトキシコロナリジン塩酸塩の合成及び抗たんでき薬としての予備的評価

Author (6)： KING C-H R (Albany Molecular Res., Inc., NY, USA) ,  MECKLER H (Albany Molecular Res., Inc., NY, USA) ,  HERR R J (Albany Molecular Res., Inc., NY, USA) ,  TROVA M P (Albany Molecular Res., Inc., NY, USA) ,  GLICK S D (Albany Medical Coll., NY, USA) ,  MAISONNEUVE I M (Albany Medical Coll., NY, USA)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 10  Issue： 5  Page： 473-476  Publication year： Mar. 06, 2000 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *narcotic antagonist ,...
Semi thesaurus term： bridged compound

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JST classification (3)： Seven-membered heterocyclic compounds  (CF07110I) ,  Chromatography,electrophoresis  (CC01050S) ,  Basic research of other drugs acting on central nervous system  (GW03120U)

Substance index (5)： rac-(2β^*,4β^*,5α^*,6β^*)-21-Methoxyibogamine-18α^*-carboxylic acid methyl ester ,  (2α,4α,5β,6α)-21-Methoxyibogamine-18β-carboxylic acid methyl ester ,  18-Methoxycoronaridine ,  (2α,4α,5β,6α)-16-[[(4β)-6-Oxo-7,7-dimethylbicyclo[2.2.1]heptan-1α-yl]methylsulfonyl]-21-methoxyibogamine-18β-carboxylic acid methyl ester ,  16-[[(4β)-6-Oxo-7,7-dimethylbicyclo[2.2.1]heptan-1α-yl]methylsulfonyl]-21-methoxyibogamine-18-carboxylic acid methyl ester

Terms in the title (5)： エナンチオマ ,  18-メトキシコロナリジン ,  塩酸塩 ,  たんでき ,  評価