Art

J-GLOBAL ID：200902131052553880   Reference number：02A0829901

A Very Late Activating Antigen-α4 (CD49d) Monoclonal Antibody, BU49 Induces Phosphorylation of a cAMP Response Element-Binding Protein (CREB), Resulting in Induction of Homotypic Cell Aggregation and Enhancement of Interleukin-8 (IL-8) Production.

VLA抗原α4(CD49d)モノクローナル抗体のBU49はcAMP応答配列結合蛋白質(CREB)のりん酸化を誘導し,同型細胞凝集とIL8産生増加をもたらす

Author (2)： IKEWAKI N (Kyushu Univ. Health and Welfare, Fac. Health and Sci., Miyazaki, JPN) ,  INOKO H (Tokai Univ. School of Medicine, Kanagawa, JPN)
Material： Microbiology and Immunology  (Microbiol Immunol)
Volume： 46  Issue： 10  Page： 685-695  Publication year： Oct. 20, 2002 
JST Material Number： F0715A  ISSN： 0385-5600  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *monoclonal antibody ,...
Semi thesaurus term： BU49 ,...

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JST classification (1)： Biochemistry of antigens,antibodies,complements  (ED04020L)

Substance index (1)： H-89

Reference (48)：

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• ALBELDA, S. M. Molecular and cellular properties of PECAM-1 (endo CAM/CD31) : a novel vasucular cell-cell adhesion molecule. J. Cell Biol. 1991, 114, 1059-1068
• ARMSTRONG, R. C. Transsynaptic control of gene expression. Annu. Rev. Neurosci. 1993, 16, 17-29
• BEDNARCZYK, J. L. A monoclonal antibody to VLA-4 alpha-chain (CDw49d) induces homotypic lymphocyte aggregation. J. Immunol. 1990, 144, 777-784
• BERLIN, C. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin-1 (MAdCAM-1). Cell. 1993, 74, 185-195

Terms in the title (8)： VLA抗原 ,  モノクローナル抗体 ,  cAMP応答配列結合蛋白質 ,  CREB ,  りん酸化 ,  誘導 ,  細胞凝集 ,  IL8