Art

J-GLOBAL ID：200902131053621189   Reference number：97A0786412

2-Cyclopropylindoloquinones and Their Analogues as Bioreductively Activated Antitumor Agents: Structure-Activity in Vitro and Efficacy in Vivo.

生体還元的に活性化される抗腫よう薬としての2-シクロプロピルインドロキノン類および類縁体 in vitroの構造-活性相関とin vivo効力

Author (9)： NAYLOR M A (Mount Vernon Hospital, Middlesex, GBR) ,  JAFFAR M (Univ. Manchester, Manchester, GBR) ,  NOLAN J (Medical Res. Council, Oxon, GBR) ,  STEPHENS M A (Medical Res. Council, Oxon, GBR) ,  BUTLER S (Medical Res. Council, Oxon, GBR) ,  PATEL K B (Mount Vernon Hospital, Middlesex, GBR) ,  EVERETT S A (Mount Vernon Hospital, Middlesex, GBR) ,  ADAMS G E (Mount Vernon Hospital, Middlesex, GBR) ,  STRATFORD I J (Univ. Manchester, Manchester, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 40  Issue： 15  Page： 2335-2346  Publication year： Jul. 18, 1997 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： quinone ,...
Semi thesaurus term： indolines ,...

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Condensed derivatives of pyrroles  (CF07077C)

Substance index (35)： Mitomycin ,  Carbamic acid [[2,3,5,8-tetrahydro-5,8-dioxo-1,2-methano-7-(aziridin-1-yl)-1H-pyrrolo[1,2-a]indol]-9-yl]methyl ester ,  EO-9 ,  EO-7 ,  6-Methoxy-8-(hydroxymethyl)-1,1a,2,8b-tetrahydro-1-carbaazirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione ,  6-(Aziridin-1-yl)-8-(hydroxymethyl)-1,1a,2,8b-tetrahydro-1-carbaazirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione ,  1-Methyl-2-cyclopropyl-5-methoxy-4,7-dihydro-4,7-dioxo-1H-indole-3-carboxylic acid methyl ester ,  1-Methyl-2-cyclopropyl-3-hydroxymethyl-5-methoxy-1H-indole-4,7-dione ,  1-Methyl-2-cyclopropyl-3-(carbamoyloxymethyl)-5-methoxy-1H-indole-4,7-dione ,  1-Methyl-2-cyclopropyl-5-(aziridin-1-yl)-4,7-dihydro-4,7-dioxo-1H-indole-3-carboxylic acid methyl ester ,  1-Methyl-2-cyclopropyl-3-hydroxymethyl-5-(aziridin-1-yl)-1H-indole-4,7-dione ,  1-Methyl-2-cyclopropyl-3-[[(aminocarbonyl)oxy]methyl]-5-(aziridin-1-yl)-1H-indole-4,7-dione ,  1-Methyl-2-cyclopropyl-3-hydroxymethyl-5-(2-methylaziridin-1-yl)-1H-indole-4,7-dione ,  1-Methyl-2-cyclopropyl-3-[[(aminocarbonyl)oxy]methyl]-5-(2-methylaziridin-1-yl)-1H-indole-4,7-dione ,  1-Methyl-2-isopropyl-5-methoxy-4,7-dihydro-4,7-dioxo-1H-indole-3-carboxylic acid methyl ester ,  1-Methyl-2-isopropyl-3-hydroxymethyl-5-methoxy-1H-indole-4,7-dione ,  1-Methyl-2-isopropyl-3-hydroxymethyl-5-(aziridin-1-yl)-1H-indole-4,7-dione ,  1-Methyl-2-isopropyl-3-hydroxymethyl-5-(2-methylaziridin-1-yl)-1H-indole-4,7-dione ,  1-Methyl-2-isopropyl-3-(carbamoyloxymethyl)-5-methoxy-1H-indole-4,7-dione ,  1-Methyl-2-isopropyl-3-[[(aminocarbonyl)oxy]methyl]-5-(aziridin-1-yl)-1H-indole-4,7-dione ,  1-Methyl-2-isopropyl-3-[[(aminocarbonyl)oxy]methyl]-5-(2-methylaziridin-1-yl)-1H-indole-4,7-dione ,  1,3-Dimethyl-2-isopropyl-5-methoxy-1H-indole-4,7-dione ,  1,3-Dimethyl-2-isopropyl-5-(aziridin-1-yl)-1H-indole-4,7-dione ,  1-Methyl-2-cyclohexyl-3-(hydroxymethyl)-5-methoxy-1H-indole-4,7-dione ,  1-Methyl-2-cyclohexyl-3-(hydroxymethyl)-5-(aziridin-1-yl)-1H-indole-4,7-dione ,  1,2-Dimethyl-3-(hydroxymethyl)-5-methoxy-1H-indole-4,7-dione ,  ES-921 ,  1,2-Dimethyl-3-(hydroxymethyl)-5-(2-methyl-1-aziridinyl)-1H-indole-4,7-dione ,  1,2-Dimethyl-3-(hydroxymethyl)-5-(2,3-dimethylaziridin-1-yl)-1H-indole-4,7-dione ,  1,2-Dimethyl-3-(hydroxymethyl)-5-[(2-hydroxy-2-methylpropyl)amino]-1H-indole-4,7-dione ,  1-Methyl-3-(hydroxymethyl)-5-methoxy-1H-indole-4,7-dione ,  1-Methyl-5-(2-methyl-1-aziridinyl)-3-(hydroxymethyl)-1H-indole-4,7-dione ,  1-Methyl-3-(hydroxymethyl)-5-(1-aziridinyl)-1H-indole-4,7-dione ,  3-(Carbamoyloxymethyl)-1-methyl-5-methoxy-1H-indole-4,7-dione ,  1-Methyl-5-(1-aziridinyl)-3-[(carbamoyloxy)methyl]-1H-indole-4,7-dione

Terms in the title (6)： 生体 ,  還元 ,  活性化 ,  抗腫よう薬 ,  類縁体 ,  構造-活性相関