Art

J-GLOBAL ID：200902165017579305   Reference number：98A0527001

Synthesis and Structure - Activity Relationships of Carboxyflavones as Structurally Rigid CysLT₁(LTD₄) Receptor Antagonists.

構造固定CysLT₁(LTD₄)受容体きっ抗薬としてのカルボキシフラボンの合成と構造活性相関

Author (7)： ZWAAGSTRA M E (Vrije Univ., Amsterdam, NLD) ,  TIMMERMAN H (Vrije Univ., Amsterdam, NLD) ,  VAN DE STOLPE A C (Vrije Univ., Amsterdam, NLD) ,  DE KANTER F J J (Vrije Univ., Amsterdam, NLD) ,  TAMURA M (Kowa Co. Ltd., Tokyo, JPN) ,  WADA Y (Kowa Co. Ltd., Tokyo, JPN) ,  ZHANG M-Q (Vrije Univ., Amsterdam, NLD)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 41  Issue： 9  Page： 1428-1438  Publication year： Apr. 23, 1998 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： aromatic carboxylic acid ,...
Semi thesaurus term： leukotriene receptor ,...

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JST classification (2)： Basic research of histaminergic drugs and antihistaminergic drugs  (GW06010V) ,  Quinolines,isoquinolines  (CF07096H)

Substance index (26)： 2-[4-[2-(2-Quinolyl)ethenyl]phenyl]-4-oxo-4H-1-benzopyran-8-carboxylic acid ,  VUF-5017 ,  2-[3-[2-(2-Quinolyl)ethenyl]phenyl]-4-oxo-6-fluoro-4H-1-benzopyran-8-carboxylic acid ,  2-[3-[2-(2-Quinolyl)ethenyl]phenyl]-4-oxo-6-methyl-4H-1-benzopyran-8-carboxylic acid ,  2-[3-[2-(2-Quinolyl)ethenyl]phenyl]-4-oxo-6-chloro-4H-1-benzopyran-8-carbonitrile ,  2-[3-[2-(2-Quinolyl)ethenyl]phenyl]-4-oxo-4H-1-benzopyran-7-carboxylic acid ,  2-[4-[2-(2-Quinolyl)ethenyl]phenyl]-4-oxo-4H-1-benzopyran-6-carboxylic acid ,  2-[3-[2-(2-Quinolyl)ethenyl]phenyl]-4-oxo-4H-1-benzopyran-6-carboxylic acid ,  2-[3-[2-(2-Quinolyl)ethenyl]phenyl]-4-oxo-4H-1-benzopyran-6-carbonitrile ,  2-[3-(Benzyloxy)phenyl]-4-oxo-4H-1-benzopyran-8-carboxylic acid ,  2-[4-(Benzyloxy)phenyl]-4-oxo-4H-1-benzopyran-8-carboxylic acid ,  2-[4-(Benzyloxy)phenyl]-4-oxo-4H-1-benzopyran-6-carboxylic acid ,  2-[3-[(2-Quinolyl)methoxy]phenyl]-4-oxo-4H-1-benzopyran-8-carboxylic acid ethyl ester ,  2-[4-[(2-Quinolyl)methoxy]phenyl]-4-oxo-4H-1-benzopyran-8-carboxylic acid ethyl ester ,  VUF-4918 ,  VUF-4871 ,  2-[4-[(2-Naphthyl)methoxy]phenyl]-4-oxo-4H-1-benzopyran-8-carboxylic acid ,  2-[4-[(2-Quinazolinyl)methoxy]phenyl]-4-oxo-4H-1-benzopyran-8-carboxylic acid ,  VUF-5165 ,  2-[3-[(2-Naphthyl)methoxy]phenyl]-4-oxo-6-bromo-4H-1-benzopyran-8-carboxylic acid ,  2-[3-[(2-Quinazolinyl)methoxy]phenyl]-4-oxo-6-bromo-4H-1-benzopyran-8-carboxylic acid ,  2-[3-[(2-Benzothiazolyl)methoxy]phenyl]-4-oxo-6-bromo-4H-1-benzopyran-8-carboxylic acid ,  2-[3-[(1-Methyl-1H-benzimidazole-2-yl)methoxy]phenyl]-4-oxo-6-bromo-4H-1-benzopyran-8-carboxylic acid ,  2-[3-[(7-Chloro-2-quinolyl)methoxy]phenyl]-4-oxo-6-bromo-4H-1-benzopyran-8-carboxylic acid ,  2-[4-[(2-Quinolyl)methoxy]phenyl]-4-oxo-6-bromo-4H-1-benzopyran-8-carboxylic acid ,  N-(Phenylsulfonyl)-2-[4-[(2-quinolyl)methoxy]phenyl]-4-oxo-6-bromo-4H-1-benzopyran-8-carboxamide

Terms in the title (2)： 受容体きっ抗薬 ,  構造活性相関