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J-GLOBAL ID：200902165074370242   Reference number：00A0808370

Mutation Analysis of Gsα, Adrenocorticotropin Receptor and p53 Genes in Japanese Patients with Adrenocortical Neoplasms. Including a Case of Gsα Mutation.

副腎皮質腫ようの日本人患者におけるGsα,ACTH受容体及びp53遺伝子の変異解析 Gsα変異の症例報告を含む

Author (6)： KOBAYASHI H (Kyoto Univ. Graduate Shool of Medicine, Kyoto, JPN) ,  USUI T (Kyoto Univ. Graduate Shool of Medicine, Kyoto, JPN) ,  FUKATA J (Kyoto Univ. Graduate Shool of Medicine, Kyoto, JPN) ,  YOSHIMASA T (Kyoto Univ. Graduate Shool of Medicine, Kyoto, JPN) ,  OKI Y (Hamamatsu Univ. School of Medicine, Hamamatsu, JPN) ,  NAKAO K (Kyoto Univ. Graduate Shool of Medicine, Kyoto, JPN)
Material： Endocrine Journal  (Endocr J)
Volume： 47  Issue： 4  Page： 461-466  Publication year： Aug. 2000 
JST Material Number： F0625A  ISSN： 0918-8959  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： ACTH ,...
Semi thesaurus term： tumorigenesis ,...

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JST classification (3)： Carcinogenic mechanisms and factors  (GE02020C) ,  Tumors(=neoplasms)of endocrine system  (GL04000P) ,  Molecular genetics in general  (EC02010J)

Reference (24)：

• 1). Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Valler L (1989) GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 340: 692-696.
• 2). Valler L, Spada A, Giannattasio G (1987) Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Science 330: 566-568.
• 3). Tordjman K, Stern N, Ouaknine G, Yossiphov Y, Razon N, Nordenskjold, Freidman E (1993) Activating mutations of the Gsα-gene in nonfunctioning pituitary tumors. J Clin Endocrinol Metab 77: 765-769.
• 4). Spada A, Vallar L, Faglia G (1994) Cellular alterations in pituitary tumors. Eur J Endocrinol 130: 43-52.
• 5). Lyons J, Landis CA, Harsh G, Vallar L, Grunewald K, Feichtinger H, Duh QY, Clark OH, Kawasaki E, Bourne HR, McCormick F (1990) Two G protein oncogenes in human endocrine tumours. Science 249: 655-659.

Terms in the title (9)： 副腎皮質腫よう ,  日本人 ,  患者 ,  Gsα ,  ACTH受容体 ,  p53遺伝子 ,  変異解析 ,  変異 ,  症例報告