Art

J-GLOBAL ID：200902165080125900   Reference number：03A0055793

A Novel Potent Cell Cycle Inhibitor Dehydrophenylahistin. Enzymatic Synthesis and Inhibitory Activity toward Sea Urchin Embryo.

新規強力細胞周期阻害剤デヒドロフェニルアヒスチン 酵素的合成およびウニはいに対する阻害活性

Author (4)： KANZAKI H (Okayama Univ., Okayama, JPN) ,  YANAGISAWA S (Okayama Univ., Okayama, JPN) ,  KANOH K (Marine Biotechnol. Inst., Iwate, JPN) ,  NITODA T (Okayama Univ., Okayama, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 55  Issue： 12  Page： 1042-1047  Publication year： Dec. 25, 2002 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Streptomyces ,...
Semi thesaurus term： Streptomyces albulus

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JST classification (2)： Basic research of antitumor(=antineoplastic)antibiotics  (GX05040Y) ,  Synthesis of antibiotics  (GX04000Z)

Substance index (4)： (-)-Phenylahistin ,  Albonoursin ,  (E)-Dehydrophenylahistin ,  NPI-2352

Reference (11)：

• 1) SAMMES, P. G.: Naturally occurring 2,5-diketopiperazines and related compounds. Fortschr. Chrm. Org. Naturst. 32: 51-118, 1975
• 2) KANZAKI, H.; D. IMURA, T. NITODA & K. KAWAZU: Enzymatic dehydrogenation of cyclo (L-Leu-L-Phe) to a bioactive derivative, albonoursin. J. Mol. Cat. B Enz. 6: 265-270, 1999
• 3) KANZAKI, H.; D. IMURA, T. NITODA & K. KAWAZU: Effective production of a dehydro cyclic dipeptide albonoursin with pronuclear fusion inhibitory activity. II. Biosynthetic and bioconversion studies. J. Antibiotics 53: 58-62, 2000
• 4) KANZAKI, H.; D. IMURA, T. NITODA & K. KAWAZU: Enzymatic conversion of cyclic dipeptides to dehydro derivatives that inhibit cell division. J. Biosci. Bioeng. 90: 86-89, 2000
• 5) KANOH, K.; S. KOHNO, T. ASARI, T. HARADA, J. KATADA, M. MURAMARTSU, H. KAWASHIMA, H. SEKIYA & I. UNO: (-)-Phenylahistin: a new mammalian cell cycle inhibitor produced by Aspergillus ustus. Bioorg. Med. Chem. Lett. 7: 2847-2852, 1997

Terms in the title (7)： 細胞周期 ,  阻害剤 ,  デヒドロフェニルアヒスチン ,  酵素的合成 ,  ウニ ,  はい ,  阻害活性