Art

J-GLOBAL ID：200902165084746852   Reference number：95A0625983

Synthesis and Cytotoxicity of Novel Lignans.

新規なリグナン類の合成と細胞毒性

Author (9)： MIDDEL O (Univ. Groningen, Groningen, NLD) ,  WOERDENBAG H J (Univ. Groningen, Groningen, NLD) ,  VAN UDEN W (Univ. Groningen, Groningen, NLD) ,  VAN OEVEREN A (Univ. Groningen, Groningen, NLD) ,  JANSEN J F G A (Univ. Groningen, Groningen, NLD) ,  FERINGA B L (Univ. Groningen, Groningen, NLD) ,  KONINGS A W T (Univ. Groningen, Groningen, NLD) ,  PRAS N (Univ. Groningen, Groningen, NLD) ,  KELLOGG R M (Univ. Groningen, Groningen, NLD)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 38  Issue： 12  Page： 2112-2118  Publication year： Jun. 09, 1995 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： lignan ,...
Semi thesaurus term： small cell lung cancer ,...

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Other natural substances of biological origin  (CF10090R)

Substance index (18)： (3S)-3α-[(αS)-α-Hydroxy-3,4,5-trimethoxybenzyl]-4β-[2-(4-methoxy-1,3-benzodioxol-5-yl)-1,3-dithian-2-yl]-5α-(menthyloxy)-4,5-dihydrofuran-2(3H)-one ,  (3S)-3α-[(αS)-α-Hydroxy-4-(benzyloxy)-3,5-dimethoxybenzyl]-4β-[2-(4-methoxy-1,3-benzodioxol-5-yl)-1,3-dithian-2-yl]-5α-(menthyloxy)-4,5-dihydrofuran-2(3H)-one ,  (3S)-3α-[(αS)-α-(2-Ethoxyethyl)oxy-3,4,5-trimethoxybenzyl]-4β-[2-(4-methoxy-1,3-benzodioxol-5-yl)-1,3-dithian-2-yl]-5α-(menthyloxy)-4,5-dihydrofuran-2(3H)-one ,  (3S)-3α-[(αS)-α-Hydroxy-4-(benzyloxy)-3,5-dimethoxybenzyl]-4β-[2-(3,4-dihydroxy-2-methoxyphenyl)-1,3-dithian-2-yl]-5α-(menthyloxy)-4,5-dihydrofuran-2(3H)-one ,  (3S)-3α-[(αS)-α-Hydroxy-3,4,5-trimethoxybenzyl]-4β-[(4-methoxy-1,3-benzodioxol-5-yl)carbonyl]-5α-(menthyloxy)-4,5-dihydrofuran-2(3H)-one ,  (3R)-3α,4β-Bis(3,4-dimethoxybenzyl)-5α-(menthyloxy)dihydrofuran-2(3H)-one ,  (3R)-3α-(4-(Benzyloxy)-3-methoxybenzyl)-4β-[(1,3-benzodioxol-5-yl)bis(phenylthio)methyl]-5α-(menthyloxy)dihydrofuran-2(3H)-one ,  (3R)-3α-(1,3-Benzodioxol-5-ylmethyl)-4β-[(1,3-benzodioxol-5-yl)bis(phenylthio)methyl]-5α-(menthyloxy)dihydrofuran-2(3H)-one ,  (3R)-3α-(1,3-Benzodioxol-5-ylmethyl)-4β-[(1,3-benzodioxol-5-yl)bis(phenylthio)methyl]-5α-methoxydihydrofuran-2(3H)-one ,  (4R)-4β-[2-(4-Methoxy-1,3-benzodioxol-5-yl)-1,3-dithian-2-yl]-5α-(menthyloxy)-4,5-dihydrofuran-2(3H)-one ,  (4R)-4β-[2-(4-Methoxy-1,3-benzodioxol-5-yl)-1,3-dithian-2-yl]-4,5-dihydrofuran-2(3H)-one ,  (4R)-4β-[2-(1,3-Benzodioxol-5-yl)-1,3-dithian-2-yl]-4,5-dihydrofuran-2(3H)-one ,  5-Methoxypodophyllotoxin ,  Pluviatolide ,  Deoxypodophyllotoxin ,  Podophyllotoxin ,  4'-Demethylpodophyllotoxin ,  Podophyllotoxin glucoside

Terms in the title (2)： リグナン類 ,  細胞毒性