Art

J-GLOBAL ID：200902212375066105   Reference number：09A1236487

Structure of IL-17A in Complex with a Potent, Fully Human Neutralizing Antibody

強力で完全なヒト中和抗体と複合体を形成したIL-17Aの構造

Author (25)： GERHARDT Stefan (AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, GBR) ,  ABBOTT W. Mark (AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, GBR) ,  HARGREAVES David (AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, GBR) ,  PAUPTIT Richard A. (AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, GBR) ,  DAVIES Rick A. (AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, GBR) ,  NEEDHAM Maurice R.C. (AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, GBR) ,  LANGHAM Caroline (AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, GBR) ,  BARKER Wendy (AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, GBR) ,  AZIZ Azad (AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, GBR) ,  SNOW Melanie J. (AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, GBR) ,  SNOW Melanie J. (MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, GBR) ,  SNOW Melanie J. (ExSAR Corp., 11 Deer Park Drive, Suite 103, Monmouth Junction, NJ 08852, USA) ,  DAWSON Sarah (AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, GBR) ,  WELSH Fraser (MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, GBR) ,  WILKINSON Trevor (MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, GBR) ,  VAUGAN Tris (MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, GBR) ,  BESTE Gerald (MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, GBR) ,  BISHOP Sarah (MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, GBR) ,  POPOVIC Bojana (MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, GBR) ,  REES Gareth (MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, GBR) ,  SLEEMAN Matthew (MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, GBR) ,  TUSKE Steven J. (ExSAR Corp., 11 Deer Park Drive, Suite 103, Monmouth Junction, NJ 08852, USA) ,  COALES Stephen J. (ExSAR Corp., 11 Deer Park Drive, Suite 103, Monmouth Junction, NJ 08852, USA) ,  HAMURO Yoshitomo (ExSAR Corp., 11 Deer Park Drive, Suite 103, Monmouth Junction, NJ 08852, USA) ,  RUSSELL Caroline (MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, GBR)
Material： Journal of Molecular Biology  (J Mol Biol)
Volume： 394  Issue： 5  Page： 905-921  Publication year： Dec. 18, 2009 
JST Material Number： D0124B  ISSN： 0022-2836  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *interleukin ,  human(primates) ,  *neutralizing antibody ,  monoclonal antibody ,  crystal structure ,  epitope ,  antigen-antibody complex ,  recombinant protein ,  dimer ,  immunoglobulin fragment ,  disulfide bond ,  folded structure ,  loop structure ,  quarternary structure ,  complementation ,  amino acid sequence ,  antigen
Semi thesaurus term： *IL-17A ,  Fab fragment ,  パラトープ

JST classification (3)： Cytokines  (EB08090G) ,  Biochemistry of antigens,antibodies,complements  (ED04020L) ,  Molecular structure  (EB03020Y)

Terms in the title (4)： ヒト ,  中和抗体 ,  複合体 ,  IL-17A