Rchr

J-GLOBAL ID：200901000072963022 Update date: Apr. 17, 2024

TAKAHIRO OCHIYA

オチヤタカヒロ | TAKAHIRO OCHIYA

Affiliation and department：
Job title：教授
Other affiliations (1)：

National Cancer Center, Research Institute

Homepage URL (1)： http://tokyo-med-mcm.jp

Research field (1)： Medical biochemistry

Research keywords (6)：発生工学 , 分子生物学 , 遺伝子治療学 , 分子腫瘍学 , 細胞工学 , Molecular & Cellular Biology

Research theme for competitive and other funds (36)：

2022 - 2026 変形性関節症に対する間葉系間質細胞由来セクレトーム治療における作用機序の解明
2022 - 2025 破骨細胞由来エクソソーム解析による薬剤関連顎骨壊死発症メカニズム解明への挑戦
2020 - 2025 Decipher cell-cell interactions
2020 - 2025 Maximum accuracy and application of diagnostic performance by integrated analysis of cancer exosome antigen and internal RNA information
2021 - 2024 Transporter-targeted drug development against urological cancers by utilizing liquid biopsy and AI

2020 - 2023 Establishment of aminoacid transporter directed prostate cancer therapy based on the liquid biopsy

2020 - 2023 A Study on Signal Transductions of MSC Culture in Total Autologous Angiogenic Therapy

2019 - 2023 Exploration of diagnostic and therapeutic biomarkers in primary central nervous system lymphoma

2020 - 2022 Single-cell analysis for the study of breast cancer metastasis

2019 - 2022 Development of a safe and efficient methods for the collection of mesenchymal stem cell-derived extracellular vesichles for the treatment of osteoarthritis

2015 - 2020 Achievement of highly accurate diagnosis of early pancreatic cancer in Japanese patients through a comprehensive/integrated approach

2016 - 2018 Generation of hepatic progenitor cells from human hepatocytes using small molecules

2015 - 2018 The elucidation of the molecular mechanism about the acquisition of pancreatic cancer invasion ability and application to cancer therapy

2014 - 2017 Development of biomarkers and novel therapeutic targets for malignant bone and soft tissue tumors using the methods of global expression analysis

2013 - 2015 Inhibition of microRNA functions by novel nucleic acids, iMIR

2012 - 2014 Development of novel cancer specific DDS utilizing circulating microRNA-derived mechanism

2011 - 2014 Development of novel cancer therapy using miRNA containing exosome

2011 - 2014 Mechanism of senescence-associated microRNA inhibiting cell growth and metastasis

2010 - 2014 Search for novel biomarkers and therapeutic targets of malignant bone and soft tissue tumors/sarcomas using the methods of global expression analysis

2011 - 2013 Why methylation and demethylation occur simultaneously in cancers

2010 - 2012 Integrated in vit-roin vivo organization of liver tissues having a functional bile duct network

2011 - 2011 Development of novel drug delivery system for micro RNA nucleic biomedicine using exosome from human cultured cells

2008 - 2011 Approach to Molecular Development of the Drug that induces Mitotic Catastrophe in Cancer cells

2008 - 2009 マイクロアレイによる肺癌のメチル化網羅的解析と診断・治療のターゲットの検討

2005 - 2009 Atelocollagen-mediated delivery of nucleic acid medicines

2007 - 2008 Establishing a new therapeutic strategy for liver failure by recycling phlebotomized blood cells

2007 - 2008 Development and application of functionalized nanocapsules

2000 - 2004 アテロコラーゲン包埋法の応用

1997 - 1999 c-Ha-rasトランスジェニックラットの発がん感受性の解析

1990 - 1990 B型肝炎ウイルスの増殖に関わる因子の研究

1988 - 1990 Studies on the Mechanism of Infection and Replication of Hepatitis B Virus

1989 - 1989 B型肝炎ウイルスの増殖・組込みと肝癌発生との関連

1989 - 1989 肝炎ウイルスと肝癌発生

1988 - 1988 肝炎ウイルスと肝癌発生

1.幹細胞の増殖分化 2.遺伝子改変動物によるがん関連遺伝子の機能解析 3.バイオマテリアルによる遺伝子デリバリー技術の開発

1.Hepatic stem cell differentiation 2.Genetic animal models for cancer genomics 3.Biomaterial-based novel gene transfer technology

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Papers (656)：

Fumihiko Urabe, Yuta Yamada, Shutaro Yamamoto, Shunsuke Tsuzuki, Shoji Kimura, Takahiro Ochiya, Takahiro Kimura. Extracellular vesicles and prostate cancer management: a narrative review. Translational andrology and urology. 2024. 13. 3. 442-453
Ryuichi Ono, Makiko Kuwagata, Mie Naruse, Akihito Watanabe, Masao Takano, Takuro Hasegawa, Hiromasa Takashima, Yusuke Yoshioka, Takahiro Ochiya, Yoko Hirabayashi, et al. Extracellular vesicle small RNAs secreted from mouse amniotic fluid induced by repeated oral administration of VPA to pregnant mice. Fundamental Toxicological Sciences. 2024. 11. 1. 37-56
Tomohiro Umezu, Shogo Tanaka, Shoji Kubo, Masaru Enomoto, Akihiro Tamori, Takahiro Ochiya, Y.-H. Taguchi, Masahiko Kuroda, Yoshiki Murakami. Characterization of circulating miRNAs in the treatment of primary liver tumors. Cancer Reports. 2023
Nobutaka Takeda, Atsunori Tsuchiya, Masaki Mito, Kazuki Natsui, Yui Natusi, Yohei Koseki, Kei Tomiyoshi, Fusako Yamazaki, Yuki Yoshida, Hiroyuki Abe, et al. Analysis of distribution, collection, and confirmation of capacity dependency of small extracellular vesicles toward a therapy for liver cirrhosis. Inflammation and regeneration. 2023. 43. 1. 48-48
Sakura Minami, Daichi Chikazu, Takahiro Ochiya, Yusuke Yoshioka. Extracellular vesicle-based liquid biopsies in cancer: Future biomarkers for oral cancer. Translational oncology. 2023. 38. 101786-101786

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MISC (338)：

山元智史, 中山淳, 落谷孝広, 山本雄介. Alteration of Drug Sensitivity and Metastatic Ability with Human Plasma-Like Medium Culture in Breas. 日本がん転移学会学術集会・総会プログラム抄録集. 2023. 32nd
松崎潤太郎, 津川仁, 中山淳, 山本雄介, 加藤健, 大田信行, 大嶋一輝, 勝田菜友, 吉岡祐亮, 落谷孝広, et al. 加齢による腸内細菌-宿主応答の変化に注目した新規発がんリスクバイオマーカーの探索. がん予防学術大会プログラム・抄録集. 2023. 2023
Tomofumi Yamamoto, Takayuki Mizutani, Yusuke Yoshioka, Takahiro Ochiya. Aberrant Serine Metabolism Promotes Bone metastasis via Extracellular Vesicles Secretion. CANCER SCIENCE. 2022. 113. 1407-1407
山元智史, 山元智史, 中山淳, 山本雄介, 落谷孝広. Aberrant Secretion of Extracellular Vesicles by Increased Serine Metabolism Promotes Breast Cancer Metastasis. 日本がん転移学会学術集会・総会プログラム抄録集. 2022. 31st
山元智史, 山元智史, 中山淳, 山本雄介, 落谷孝広. Aberrant Secretion of Extracellular Vesicles by Increased Serine Metabolism Promotes Breast Cancer Metastasis. 日本がん転移学会学術集会・総会プログラム抄録集. 2022. 31st

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Books (5)：

改訂第3版「バイオ実験の進め方」佐々木博己(編)
羊土社 2007 ISBN:9784897069234
バイオテクノロジージャーナル「生きた細胞を自在に操るテクノロジーレーザー技術が拓くナノバイオの新しい世界」
羊土社 2005 ISBN:9784897061627
実験法Q&Aシリーズ「遺伝子導入なるほどQ&A」落谷孝広(編) 青木一教(編)
羊土社 2005 ISBN:9784897064819
Antisense approaches to in vitro organ culture., T. Ochiya and M. Terada
ANTISENSE TECHNOLOGY Methods in Enzymology, 314: 401-411 (1999).
Antisense approaches to in vitro organ culture. T. Ochiya and M. Terada ANTISENSE TECHNOLOGY
ANTISENSE TECHNOLOGY Methods in Enzymology, 314: 401-411 (1999).

Professional career (1)：

Ph.D.

Work history (12)：

2019 - 現在 National Cancer Center, Research Institute
2018 - 現在 Tokyo Medical University
2018 - 2019 国立がん研究センター研究所分子細胞治療研究分野プロジェクトリーダー
2010 - 2018 National Cancer Center, Research Institute
1998 - 2010 国立がんセンター研究所がん転移研究室室長

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Committee career (1)：

2002 - 日本癌学会評議員

Awards (8)：

2019 - 高松宮妃癌研究基金学術賞
2019 - ISEV (The International Society for Extracellular Vesicles) Special Achievement Award
2019 - 文部科学省ナノテクノロジープラットフォーム「秀でた利用成果」優秀賞
2007 - 第5回IFAT国際会議学会賞
2006 - 日本人工臓器学会オリジナル賞

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Association Membership(s) (9)：

Japan Society for Extracellular Vesicles , 日本分子生物学会 , 日本生化学会 , 日本癌学会 , 日本遺伝子治療学会 , The Molecular Biology Society of JAPAN , The Japanese Biochemical Society , The Japan Society of Gene Therapy , Japanese Cancer Association

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