Rii Ko

2018 - 2020 新規急速液体凍結法「凍眠」を用いた移植用臓器保存法の確立およびその機序の解明

2017 - 2020 Establishment of antibody drug on non-alcoholic steatohepatitis through Met signaling.

2017 - 2020 International collaborative effort to study of pathophysiology and development of novel therapy of congenital sideroblastic anemia

2016 - 2019 Development of next-generation immunosuppressive therapy in organ transplantation using anti-CD70 antibody

2016 - 2019 The efficacy of hidrogen-rich solution in ischemia-reperfusion injury and intravital imaging of neutrophil recruitment in liver transplantation

2015 - 2019 Transplantation tolerance by regulatory immune response through innate immunity stimulation

2016 - 2018 A novel cancer treatment by a combination of irradiation and application of iPS cells

2015 - 2018 臓器移植後の免疫抑制剤腎障害の発生機序の解明と新規保護物質の開発に関する研究

2015 - 2018 The application of high pressure gas preservation method in small intestine transplantation

2014 - 2017 Macrophage specific delivery of TNF-a inhibits NASH liver injury.

2014 - 2016 The permanent survival of allografts by tolerance induction mediated by the combined therapy of adoptive transfer of Treg cells and the MF-1-gene transfection

2013 - 2016 Elucidation of mechanisms of high pressure gas preservation method for clinical application in amputated limb preservation

2013 - 2016 Basic research on Photodynamic Therapy in pediatric refractory cancer

2013 - 2016 Permanent acceptance of allografts with CD40 siRNA by use of a novel polysaccharide siRNA delivery system.

2012 - 2015 移植後免疫寛容の誘導における調節T細胞の役割の解明及び心臓乾燥保存法の開発

2011 - 2015 To establish the next generation method for immune cell therapy in transplantation

2010 - 2014 Molecular Imaging Research for Forefront of Cardiovascular Medicine

2009 - 2014 Novel approach of induction of donor specific immune tolerance: adoptive transfer of Treg cells combined with MF1 gene transfection

2011 - 2013 Explore the hepatic niche: spatiotemporal analyses of mesenchymal stem cells using live imaging technique

2011 - 2012 Establishment of immune cell therapy using iPS-derived MDSC

2010 - 2012 臓器移植後免疫寛容機序の解明

2010 - 2012 The clarify of the mechanism of induction of immunological tolerance using mouse liver transplantation model and development of novel immunosuppression.

2009 - 2010 iPS細胞を用いた制御性樹状細胞への分化誘導および免疫細胞療法の開発に関する研究

2008 - 2010 Establishment of immune cell therapy for transplant medical application

2008 - 2009 3種抗体、および、レンチウイルスを用いた移植腎生着延長の試み

2007 - 2009 Induction of kidney graft tplerance using donor-specofoc regulatory T cells

2006 - 2009 A trial of permanent functional renal allografts : combined therapy using a novel approach involving induction of immune tolerance and MF1 gene transfection

2005 - 2007 The mechanisms of the induction and maintenance of the transplantation tolerance and usage of the Treg cells as a cellular therapy for treatment allograft rejection and GvHD

2002 - 2004 HUMAN UMBILICAL CORD BLOOD-DERIVED CELLS DIFFERENTIATE INTO HEPATOCYTE-LIKE CELLS IN THE LIVER INJURY MODEL

2002 - 2004 GENE-EXPRESSION PROFILES OF THE PERIPHERAL BLOOD MONONUCLEAR CELLS FROM TOLERANT RAT AND LIVING-DONOR LIVER TRANSPLANT RECIPIENTS

2002 - 2003 幹細胞移植による子宮内胎児治療法の確立に関する研究

2001 - 2002 DEVELOPMENT OF TRANSPLANTATION REPLACEMENT TREATMENT BY IN UTERO TRANSPLANTATION OF ALLOGENEIC AND XENOGENEIC CELLS INTO FETAL LIVER

2000 - 2001 PROLONGED SURVIVAL OF RAT LIVER ALLOGRAFTS TRANSFECTED WITH ADENOVIRUS VECTORS CONTAINNING FAS-LIGAND AND CRM A GENES

1999 - 2000 Development of the therapy for hepatic congenital metabolic disease by In-Utero-Manipulation.

1998 - 2000 Induction of transplantation tolerance based on bio-molecular technique

1997 - 1999 Development of cell therapy for hepatic failure due to dysfunction of hepatic parenchymal cells.

The induction of immune tolerance after organ transplantation