Rchr
J-GLOBAL ID：200901001290528989
Update date: Oct. 25, 2021
Itou Hiroshi
イトウ ヒロシ | Itou Hiroshi
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Affiliation and department：
National Institute of Genetics Structural Biology Center
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Detailed information
Job title：
Assistant Professor
Research field (1)：
Structural biochemistry
Research keywords (2)：
タンパク質X線結晶構造解析学
, Protein Xray Crystallography
Research theme for competitive and other funds (8)：
2013 - 2014 DNA複製開始機構を時系列で可視化し、その分子機構を明らかとする試み
2013 - 2014 DNA複製開始調節に関与するSld3-Sld7複合体の構造生物学的研究
2009 - 2011 転写開始複合体によるプロモーター依存的転写レベル調節機構の構造学的研究
2009 - Structural study of ColE2-Rep an unique DNA replication initiator protein
2009 - Structural studies of promoter-dependent transcription level control by the transcription initiation complex
2006 - 2008 Structural study of multidrug recognition mechanism of bacterial multidrug resistance related transcription factor
2006 - 2007 バクテリア新規多剤調節因子による多剤認識機構の構造学的研究
2002 - 2007 Structural genomics of the proteins involved in transcription and translation
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Papers (16)：
Hiroshi Itou, Masaru Yagura, Yasuo Shirakihara, Tateo Itoh. Structural Basis for Replication Origin Unwinding by an Initiator Primase of Plasmid ColE2-P9 DUPLEX DNA UNWINDING BY A SINGLE PROTEIN. JOURNAL OF BIOLOGICAL CHEMISTRY. 2015. 290. 6. 3601-3611
Hiroshi Itou, Sachiko Muramatsu, Yasuo Shirakihara, Hiroyuki Araki. Crystal Structure of the Homology Domain of the Eukaryotic DNA Replication Proteins SId3/Treslin. STRUCTURE. 2014. 22. 9. 1341-1347
Hironori Aramaki, Hiroyuki Kabata, Shuso Takeda, Hiroshi Itou, Hideki Nakayama, Nobuo Shimamoto. Formation of repressor-inducer-operator ternary complex: negative cooperativity of d-camphor binding to CamR. GENES TO CELLS. 2011. 16. 12. 1200-1207
Hironori Aramaki, Hiroyuki Kabata, Shuso Takeda, Hiroshi Itou, Hideki Nakayama, Nobuo Shimamoto. Formation of repressor-inducer-operator ternary complex: negative cooperativity of d-camphor binding to CamR. GENES TO CELLS. 2011. 16. 12. 1200-1207
Hiroshi Itou, Nobuhisa Watanabe, Min Yao, Yasuo Shirakihara, Isao Tanaka. Crystal Structures of the Multidrug Binding Repressor Corynebacterium glutamicum CgmR in Complex with Inducers and with an Operator. JOURNAL OF MOLECULAR BIOLOGY. 2010. 403. 2. 174-184
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MISC (12)：
Hiroshi Itou, Nobuhisa Watanabe, Min Yao, Yasuo Shirakihara, Isao Tanaka. Crystal structures of the multidrug binding repressor corynebacterium glutamicum CgmR in Complex with Inducers and with an Operator. Journal of Molecular Biology. 2010. 403. 2. 174-184
Yong-Gui Gao, Hiroaki Suzuki, Hiroshi Itou, Yong Zhou, Yoshikazu Tanaka, Masaaki Wachi, Nobuhisa Watanabe, Isao Tanaka, Min Yao. Structural and functional characterization of the LldR from Corynebacterium glutamicum: a transcriptional repressor involved in L-lactate and sugar utilization. NUCLEIC ACIDS RESEARCH. 2008. 36. 22. 7110-7123
Yong-Gui Gao, Min Yao, Hiroshi Itou, Yong Zhou, Isao Tanaka. The structures of transcription factor CGL2947 from Corynebacterium glutamicum in two crystal forms: A novel homodimer assembling and the implication for effector-binding mode. PROTEIN SCIENCE. 2007. 16. 9. 1878-1886
Hiroshi Itou, Min Yao, Nobuhisa Watanabe, Isao Tanaka. Crystal structure of the PH1932 protein, a unique archaeal ArsR type winged-HTH transcription factor from Pyrococcus horikoshii OT3. Proteins. 2007. 70. 1931-1634
H Itou, U Okada, H Suzuki, M Yao, M Wachi, N Watanabe, Tanaka, I. The CGL2612 protein from Corynebacterium glutamicum is a drug resistance-related transcriptional repressor - Structural and functional analysis of a newly identified transcription factor from genomic DNA analysis. JOURNAL OF BIOLOGICAL CHEMISTRY. 2005. 280. 46. 38711-38719
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Books (3)：
遺伝子が語る生命38億年の謎 なぜ、ゾウはネズミより長生きか?
悠書館 2014
遺伝子図鑑
悠書館 2013
分子生物学への招待
三共出版 2002
Lectures and oral presentations (20)：
Structure of the homology domain of the DNA replication proteins Sld3/Treslin
(23rd congress and general assembly of the international union of crystallography 2014)
Sld3とTreslinが持つ相同領域の立体構造に基づいたSld3-Cdc45相互作用の考察
(第14回蛋白質科学会年会 2014)
Sld3とTreslinが持つ相同領域の立体構造に基づいたSld3-Cdc45相互作用の考察
(第31回PFシンポジウム 2014)
Sld3とTreslinが持つ相同領域の立体構造に基づいたSld3-Cdc45相互作用の考察
(第36回日本分子生物学会 2013)
複製開始因子ColE2-Rep DNA結合領域と複製開始点との複合体の結晶構造解析:プライマーゼ活性を持つユニークなRepタンパク質による特異的ori認識ならびに2本鎖DNA解裂機構の構造学的研究
(第35回日本分子生物学会年会 2012)
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Education (4)：
- 2002 Hokkaido University
- 2002 Hokkaido University Graduate School, Division of Natural Science
- 1997 University of Tsukuba
- 1997 University of Tsukuba Second Cluster of College
Professional career (1)：
Doctor of Philosophy (Hokkaido University)
Work history (7)：
2007 - - 国立遺伝学研究所助教
2005 - 2006 National Institute of Genetics
2005 - - Assistant professor at National Institute of Genetics
2002 - 2004 北海道大学理学研究科博士研究員
2002 - 2004 Post doctoral fellow at Hokkaido University
1998 - 2001 日本学術振興会特別研究員
1998 - 2001 Research fellow of the Japan Society for Promotion of Science
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Association Membership(s) (6)：
日本分子生物学会
, 日本結晶学会
, 日本生化学会
, The molecular biology society of Japan
, The crystallographic society of Japan
, The Japanese biochemical society
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