Research field (3)：
Medical biochemistry
, Cell biology
, Molecular biology
Research keywords (7)：
バイオイメージング
, 癌
, シグナル伝達
, 増殖因子
, Cancer
, Signal Transduction
, Growth Factor
Research theme for competitive and other funds (57)：
2022 - 2028 Advanced Bioimaging Support
2023 - 2027 Construction of control technology for cell behavior and bone tissue formation using metallographic microstructures
2021 - 2024 Elucidation of the pathophysiology of OA fibrosis and establishment of therapeutic methods using innovative imaging technology and single-cell analysis
2021 - 2024 上皮間葉転換の生体内動態可視化によるがん転移の時空間的理解と新規治療法開発
2015 - 2021 Accelerating international cooperative researches
2016 - 2021 先端バイオイメージング支援プラットフォーム
2015 - 2020 Cancer metastasis research that makes full use of innovative imaging technology and medaka as a model of cancer
2015 - 2020 Resonance Biology for Innovative Bioimaging
2015 - 2018 Development of an innovative imaging system for clarifying cell-cell interactions linking cancer bone metastasis and bone metabolism
2015 - 2017 Functional analysis of Arkadia in bone metabolism using innovative imaging technique and KO mice
2013 - 2016 Bio-imaging for Cornea stromal Stem Cell Biology
2010 - 2016 Multi-dimensional fluorescent live imaging of cellular functions and molecular activities
2010 - 2015 Development of new intravital fluorescence imaging system and analysis of the cancer microenvironment
2012 - 2014 Nonliner optical imaging for deep tissue using hollow fiber bundle
2012 - 2014 Analysis of the TGF-b signaling in cartilage by nonlinear optics imaging combined with genetic engineering techniques
2011 - 2014 Development of advanced fluorescent imaging systems for the study of bone remodeling
2011 - 2012 Development of advanced in vivo EMT imaging system and its application for the study of cancer metastasis
2009 - 2011 新規骨特異的チャネル分子パネキシン3の骨形成における機能解析
2009 - 2010 革新的ユビキチンシステムイメージング法の開発
2008 - 2010 Study of TGFβ signaling during angiogenesis in bone metastasis sites by using in vivo optical imaging
2005 - 2009 Establishment of New Strategies for Treatment of Cancer Using TGF-beta Signaling
2005 - 2009 The core unit supporting research, communication, network and young scientists in the cancer research field
2007 - 2008 ユビキチンシステムのインビボイメージング法の開発
2007 - 2007 トランスジェニックマウスを用いたBMPシグナルのインビボイメージング
2006 - 2007 インビボイメージングを利用した癌転移と微小環境におけるシグナリングの解析
2005 - 2007 Analysis of TGF-β/BMP signaling during bone metastasis and development of cancer therapy
2006 - 2006 ヒト全ゲノムタイリングアレイを用いた骨軟骨細胞分化研究の新戦略
2003 - 2004 Screening of novel signal transducers for BMP using DNA affinity purification
2000 - 2004 Mechanisms of TGF-β signaling and its abnormalities in human cancer
2000 - 2004 骨格系の制御プログラムにおける骨形成因子の機能と役割
2001 - 2002 Screening and characterization of BMP-specific R-Smads binding proteins
1999 - 2001 Development of methods using protein-protein interaction to identify signaling proteins
1999 - 2001 Signal transduction by Smad proteins and their biological activities
2000 - 2000 Smadによる細胞増殖調節機構の解明
2000 - 2000 Smadの転写調節機構
2000 - 2000 BMPおよびアクチビンの細胞内シグナル伝達機構の解析
1999 - 2000 骨・軟骨形成におけるBMPsのシグナル伝達機構と生物学的作用
1999 - 2000 Signal transduction of the TGF-βsuperfamily and its disturbances.
1999 - 1999 TGF-βによる血管壁細胞の増殖調節機構の分子レベルでの解明
1999 - 1999 BMPsとアクチビンの細胞内シグナル伝達因子Smadの機能解析
1999 - 1999 Smadによる細胞増殖制御機構の解明
1998 - 1998 TGF-βによる血管壁細胞の増殖調節機構の分子レベルでの解明
1998 - 1998 セリン・スレオニンキナーゼ型レセプターの情報伝達経路の解明
1998 - 1998 Smadによる細胞増殖制御機構の解明
1997 - 1998 Signainrg Mechanism and Biological Action of the Members of the Transforming Growh Factor beta Superfamily
1997 - 1997 骨・軟骨形成におけるBMPsのシグナル伝達機構と生物学的作用
1997 - 1997 TGF-Bによる血管壁細胞の増殖調節機構の分子レベルでの解明
1997 - 1997 セリン・スレオニンキナーゼ型レセプターの情報伝達経路の解明
1997 - 1997 Smadがん抑制遺伝子産物による細胞増殖制御機構の解明
1994 - 1995 Biomolecular Analysis on Decorin associated with Ossification of the Longitudinal Ligament
1994 - Signal transduction of TGF-B superfamily
バイオイメージング
TGF-β/BMPシグナル伝達
がんの細胞生物学
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Papers (210)：
Kazuki Yatsuzuka, Ryosuke Kawakami, Yosuke Niko, Teruko Tsuda, Kenji Kameda, Nobushige Kohri, Satoshi Yoshida, Ken Shiraishi, Jun Muto, Hideki Mori, et al. A fluorescence imaging technique suggests that sweat leakage in the epidermis contributes to the pathomechanism of palmoplantar pustulosis. Scientific reports. 2024. 14. 1. 378-378
Mai Nagasaka, Yasumichi Inoue, Yuji Nagao, Chiharu Miyajima, Daisuke Morishita, Hiromasa Aoki, Mineyoshi Aoyama, Takeshi Imamura, Hidetoshi Hayashi. SET8 is a novel negative regulator of TGF-β signaling in a methylation-independent manner. Scientific Reports. 2023. 13. 1
Tatsuya Konishi, Toshiki Ochi, Masaki Maruta, Kazushi Tanimoto, Yukihiro Miyazaki, Chika Iwamoto, Takashi Saitou, Takeshi Imamura, Masaki Yasukawa, Katsuto Takenaka. Reinforced anti-myeloma therapy via dual-lymphoid activation mediated by a panel of antibodies armed with Bridging-BiTE. Blood Journal. 2023
Takashi Saitou, Takeshi Imamura. Extended Depth of Focus Two-Photon Light-Sheet Microscopy for In Vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution. International journal of molecular sciences. 2023. 24. 12
小西達矢, 越智俊元, 越智俊元, 丸田雅樹, 谷本一史, 齋藤卓, 今村健志, 安川正貴, 安川正貴, 竹中克斗. Development of novel immunotherapy for myeloma using a new BiTE-based modality. 日本血液学会学術集会抄録(Web). 2021. 83rd
2010 - 現在 Ehime University Graduate School of Medicine
Japanese Foundation for Cancer Research Cancer Institute, Biochemistry, Department of Biochemistry Department Director
Committee career (2)：
日本骨代謝学会 評議員
日本癌学会 評議員
Awards (2)：
2000 - 日本癌学会奨励賞
2000 - Incitement Award of the Japanese Cancer Association
Association Membership(s) (10)：
米国骨代謝学会 (ASBMR)
, 日本生化学会
, 日本分子生物学会
, 日本整形外科学会
, 日本骨代謝学会
, 日本癌学会
, The Molecular Biology Society of Japan
, The Japanese Society for Bone and Mineral Research
, The Japanese Orthopaedic Association
, The Japanese Cancer Association
