Rchr
J-GLOBAL ID：200901001730062340
Update date: Feb. 21, 2024
Harada Hidemitsu
ハラダ ヒデミツ | Harada Hidemitsu
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://oralhist.iwate-med.ac.jp/stuff.html
Research field (4)：
Regenerative dentistry and dental engineering
, Oral medicine
, Developmental biology
, Cell biology
Research keywords (4)：
発生生物学 歯 再生医学
, regenerative medicine
, Tooth
, Developmental Biology
Research theme for competitive and other funds (50)：
- 2023 - 2027 セメント芽細胞分化の微小環境の解明とセメント質再生医療の開発
- 2022 - 2025 歯原性細胞に依存しないiPS細胞によるエナメル芽細胞誘導と歯胚作成技法の創出
- 2021 - 2024 Elucidation of the regulatory mechanism of ameloblasts by lipid mediators and the etiology due to their destruction.
- 2020 - 2023 Clarification of the origin and maintenance mechanisms of junctional epithelium and identification of its stem cells using allogenic tooth germ transplantation
- 2019 - 2023 顎骨骨髄炎発症要因における歯原性細胞と細胞極性調節因子相互作用の解析
- 2018 - 2021 Regeneration of dentin-pulp complex from iPS cells using new odontoblasts differentiation mechanism and polarity regulation
- 2018 - 2020 ウスタビガ繭シルクプロテインとiPS細胞による歯槽骨再生技術の開発
- 2018 - 2020 マラッセ上皮遺残は歯周組織恒常性を制御するシグナルセンターか?
- 2018 - 2020 エナメル上皮細胞の動態を制御するストレス応答性糖代謝調節機構の解明
- 2016 - 2017 歯根膜間葉細胞から歯の再生のためのエナメル上皮細胞が作れるか?
- 2015 - 2016 Basic research on technology development of tooth regeneration with regard to transcription factor Cebpb and Runx2
- 2014 - 2015 Does a novel signal center exsist at outer enamel epithelium in incisor germ?
- 2012 - 2014 Relationship between development of Hertwig's epithelial root sheath and molecular mechanism that controls cell migration.
- 2012 - 2013 Is epithelial-mesenchymal transition of stellate reticulum cells in enamel organ associated with induction of vasculogenesis?
- 2010 - 2012 Interaction between dental pulp stem cells and bone-marrow-derived cells during pulpal regeneration and its clinical implication
- 2009 - 2011 Development of technical bases for biotooth formation by using iPS cells
- 2007 - 2011 Development of tooth root and regeneration
- 2009 - 2010 Research for developing drug to inhibit malignant melanoma bone metastasis by targeting Wnt5a signaling
- 2008 - 2010 Culture of human dental stem cells from human mandibular third molars and its application of the recombinant tooth germ
- 2000 - 2010 Regeneration of teeth
- 1991 - 2010 歯根の発生と再生に関する研究
- 2007 - 2009 Study on mechanisms of odontoblasts processes formation and dentin development
- 2007 - 2008 外エナメル上皮の潜在的可能性の追求と歯根再生療法への展開
- 2007 - 2008 Cell dynamics in transition stage from crown to tooth root formation and effects of growth factors in development of Hertwig epithelial root sheath
- 2007 - 2008 Possible involvement of sulfation of heparan sulfate proteoglycan in tooth regeneration.
- 2008 - ヒト歯胚細胞を用いた歯と歯周組織の再生
- 2006 - 2007 Elucidation of the capacity of dental pulp differentiation as demonstrated by autogenic and allogenic tooth transplantation
- 2004 - 2006 Regeneration of tooth germ using dental epithelial stem cells and dental papilla mesenchymal stem cells in rodent incisors
- 2004 - 2006 Development and regeneration of synapse and peripheral sensory receptors of trigeminal mesencephalic neurons
- 2004 - 2006 Research on Dental Pulp Stem Cells and Pulpal Healing Process
- 1999 - 2005 Study on cell fate decision of stem cells
- 1997 - 2005 エナメル芽細胞の増殖と分化に関する研究
- 1997 - 2005 Study on growth and differentiation of Ameloblasts
- 2003 - 2004 Localization and chronological changes of the adult stem cells in the pulpal regeneration process after tooth replantation and transplantation
- 2003 - 2004 Development of poiodontal regenerative medicine that based on molecular mechanism of cementogenesis.
- 2003 - 2004 歯髄に存在する神経提由来間葉系幹細胞の多能性および可塑性の検討
- 2002 - 2004 Cell biology of taste buds and analysis of taste transduction mechanisms
- 2001 - 2003 Elucidation of molecular mechanisms on transition from crown to root in tooth development
- 2001 - 2002 エナメル上皮幹細胞の多能性の検討
- 1999 - 2001 Neurobiology on the development and regeneration of taste buds.
- 2000 - 2000 歯胚発生研究のための培養技術の向上を目的としたワークショップ開催
- 1999 - 2000 マウス下顎切歯の器官培養法を用いたエナメル芽細胞の増殖と分化の機構の解明
- 1996 - 1997 Neurobiological Study of Taste Buds
- 1995 - 1996 Growth and differentiation of keratinocytes : Molecular and histological study
- 1995 - 1996 The study of mouse salivary gland morphogeensis.
- 歯の再生
- ヒト歯胚細胞と間葉系幹細胞のための完全合成培地の開発
- regeneration of teeth
- Drug system for regeneration of periodontal tissue.
- Development of Dental Implant with periodontal ligament
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Papers (144)：
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H Ida-Yonemochi, K Otsu, T Irié, A Ohazama, H Harada, H Ohshima. Loss of Autophagy Disrupts Stemness of Ameloblast-Lineage Cells in Aging. Journal of dental research. 2023. 220345231209931-220345231209931
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Shojiro Ikezaki, Keishi Otsu, Mika Kumakami-Sakano, Hidemitsu Harada. A novel junctional epithelial cell line, mHAT-JE01, derived from incisor epithelial cells. Journal of Oral Biosciences. 2023
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Marii Azumane, Shojiro Ikezaki, Keishi Otsu, Mika Kumakami-Sakano, Haruno Arai, Hiroyuki Yamada, Päivi Kettunen, Hidemitsu Harada. Semaphorin-RhoA signaling regulates HERS maintenance by acting against TGF -β-induced EMT. Journal of Periodontal Research. 2022
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Haruno Arai, Akira Inaba, Shojiro Ikezaki, Mika Kumakami-Sakano, Marii Azumane, Hayato Ohshima, Kazumasa Morikawa, Hidemitsu Harada, Keishi Otsu. Energy metabolic shift contributes to the phenotype modulation of maturation stage ameloblasts. Frontiers in Physiology. 2022. 13. 1062042-1062042
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依田 浩子, 大津 圭史, 原田 英光, 大島 勇人. エナメル上皮細胞分化におけるオートファジーの役割(Role of autophagy in ameloblast differentiation). Journal of Oral Biosciences Supplement. 2022. 2022. 95-95
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MISC (130)：
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稲葉陽, 稲葉陽, 池崎晶二郎, 熊上(坂野)深香, 荒井春乃, 荒井春乃, 東根まりい, 東根まりい, 大島勇人, 森川和政, et al. エナメル芽細胞におけるLPA6シグナルの役割. 日本解剖学会総会・全国学術集会講演プログラム・抄録集. 2022. 127th
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原田英光, 池崎晶二郎, 後藤(松元)奈緒美, 中西(松井)真弓, 和田洋, 孫(和田)戈虹, 依田浩子, 大島勇人, 大津圭史. 大理石骨病モデルマウスを用いた歯の病態解析. 日本実験動物学会総会講演要旨集(Web). 2022. 69th
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大津 圭史, 池崎 晶二郎, 後藤 奈緒美[松元], 中西 真弓[松井], 和田 洋, 孫 戈虹[和田], 原田 英光. 成熟期エナメル芽細胞におけるプロトンポンプの新規機能. Journal of Oral Biosciences Supplement. 2020. 2020. 147-147
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稲葉陽, 稲葉陽, 池崎晶二郎, 原田英光, 森川和政, 大津圭史. エナメル芽細胞におけるLPAシグナルの機能的役割. 日本解剖学会総会・全国学術集会講演プログラム・抄録集. 2020. 125th
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Hidemitsu Harada, Keishi Otsu. 歯の発生、萌出、乳歯歯根吸収および関連するトピックス. Japanese Journal of Clinical Dentistry for Children. 2019. 24. 5. 14-19
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Books (6)：
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歯胚上皮系細胞.歯の再生(上田実 本田雅規:編)
真與交易(株)医書出版部59-66 2006
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歯の発生・再生(発生・再生イラストマップ,上野直人 野地澄晴編)
羊土社,東京,印刷中 2005
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口腔諸器官の発生と再生 (先端歯科医学の創生,浜田茂幸 米田俊之編)
大阪大学出版会,大阪 2005
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歯の再生
(再生医学・再生医療 室田誠逸編)現代科学増刊41 東京化学同人、東京 2002
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エナメル上皮幹細胞と再生医学
(骨形成・骨吸収の分子メカニズムと骨疾患 米田俊之、加藤茂明、松本俊夫編)実験医学創刊号 羊土社 東京 2002
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Works (4)：
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歯髄及び歯胚間葉系幹細胞の増殖法の開発と分化評価
2004 - 2005
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歯胚再生のための口腔粘膜上皮からの幹細胞分離技術の開発
2003 -
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上皮-間葉の相互作用による幹細胞形成過程の分子メカニズムの解明のための共同研究
2001 - 2002
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Group research for elucidating molecular mechanisms of stem cell formation during organogenesis of epithelial-mesenchymal interaction.
2001 - 2002
Education (4)：
- - 1991 Kyushu University
- - 1991 Kyushu University Graduate School, Division of Dental Research
- - 1987 Kyushu Dental College Dentistry
- - 1987 Kyushu Dental College Faculty of Dentistry
Professional career (1)：
- (BLANK) (Kyushu University)
Work history (10)：
- 2006/04 - 現在 Iwate Medical University
- 2002 - 2006 Osaka Universiy, Associate Professor
- 2002 - 2005 Osaka University Graduate School of Dentistry
- 2000 - 2002 Kyushu Dental College
- 2000 - 2002 Kyushu Dental College, Associate Professor
- 1997 - 1999 Kyushu Dental College
- 1997 - 1999 Kyushu Dental College, Assistant Professor
- 1995 - 1997 Kyushu Dental College
- 1995 - 1997 Kyushu Dental College, Research Assistant
- 1993 - 1994 日本学術振興会 特別研究員
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Association Membership(s) (5)：
THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY
, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, 日本発生生物学会
, 歯科基礎医学会
, 日本解剖学会
