Rchr
J-GLOBAL ID:200901002125524070
Update date: Apr. 01, 2024
SAKAMOTO NAOYA
サカモト ナオヤ | SAKAMOTO NAOYA
Affiliation and department:
Job title:
教授
Research field (1):
Gastroenterology
Research keywords (2):
肝疾患
, ウイルス肝炎
Research theme for competitive and other funds (42):
- 2022 - 2025 肝線維化治療標的同定とそれに基づく新規抗肝線維化治療法開発
- 2022 - 2025 Comprehensive search for host factors related to liver fibrosis mechanisms and development of novel therapeutic strategies
- 2021 - 2024 肝癌幹細胞の維持・免疫寛容機構の解明と治療最適化の検討
- 2020 - 2023 R-Spondinによる肝幹細胞を標的とした造血幹細胞移植後肝傷害の治療開発
- 2020 - 2023 Development of novel antiviral therapy targeting hepatitis B virus host restriction factor
- 2020 - 2023 非アルコール性脂肪肝炎、新規診断マーカー・治療標的としての糖鎖修飾解析
- 2020 - 2022 Targeting the glycosylated structure of liver tissue stromal proteins to form the basis for glycosylation drug discovery for liver fibrosis.
- 2019 - 2022 High through anti-HBV drug screening by using reporter assay
- 2019 - 2022 Comprehensive screening of miviroenvirinmental factors that affect liver fibrosis
- 2018 - 2020 Development of drugs targeting liver fibrosis by modulation of protein/lipid glycosylation
- 2017 - 2020 A new development of antivirals for eradication of HBV cccDNA
- 2016 - 2019 Effect of truncated Hepatitis B virus X protein integration on malignant potential of HCC
- 2016 - 2019 Search for new cell- or small molecule-based therapies to promote regression of liver cirrohsis
- 2016 - 2018 Application of molecular dynamics simulation to construct of virtual assay system of antiviral drug resistance
- 2015 - 2018 Anti-Adipogenic and Antiviral Effects of L-Carnitine on Hepatitis C Virus Infection
- 2014 - 2017 Investigation of the HSF1 signaling pathway as the molecular targeted therapies for hepatocellular carcinoma.
- 2014 - 2016 Establishment of virtual assay system by molecular dynamic simulation of HCV antiviral resistance
- 2013 - 2015 To analyze the mechanisms of HCV drug resistance by using chimeric HCV cell culture system
- 2012 - 2015 Impaired host response and HCV disturbance of type I/III IFN signaling are closely associated with non-response to IFN-based anti-HCV treatment
- 2012 - 2015 Study on establishment of experimental animal model for chimeric liver with hepatitis C virus infection using induced hepatocyte-like cells
- 2012 - 2015 Analysis of IL-6-mediated drug-resistance of hepatitis C virus infection
- 2012 - 2015 High throughput screening of chemical library for antiviral compounds for hepatitis viruses
- 2012 - 2014 Development of drugs targeting hepatitis B x-protein
- 2010 - 2013 細胞障害性HCV培養系を用いた重症C型肝炎発症機構の解析
- 2009 - 2012 FRET/ BRET analysis of interaction between HCV protein and interferon signaling
- 2010 - 2011 Establishment of mouse-directed HCV infection models
- 2009 - 2011 Analysis on molecular mechanisms of liver reconstitution by transplanted hepatic cells
- 2009 - 2011 Development of plaque assay to isolate cytopathic HCV clones
- 2009 - 2011 High-throughput screening of virus-and host-targeted suppressors of HCV infection
- 2008 - 2009 Research on molecular mechanism of hepatic stem cell proliferation and development of mouse models for stem cell transplantation
- 2007 - 2008 Research on transplantation of hepatic stem cells and development of experimental mouse models for hepatitis C virus
- 2007 - 2008 Search for new classes of HCV therapeutics by large scale screening of antiviral compounds and host cellular factors
- 2006 - 2007 C型肝炎ウイルス発現モデル動物を用いたsiRNAによる感染抑制系の開発
- 2005 - 2006 Comprehensive screening of host proteins that suppress replication of HCV replicon
- 2005 - 2006 Study on hepatic differentiation of mesenchymal stem cells derived from human umbilical cord blood, and cell therapy for liver disease by use of mesenchymal stem cells.
- 2005 - 2005 Suppression subraction法による消化器癌の分子病態の解析
- 2004 - 2005 Identification of human cord blood-derived hepatic stem cells, and establishment of cell therapy for lethal liver disease
- 2004 - 2005 Suppression of hepatitis C virus replication by cyclosporine A
- 2003 - 2004 Therapeutic application of RNA interference to suppress hepatitis C virus replication
- 2002 - 2004 HCV VectorによるHCV感染過程の制御分子の同定
- 2002 - 2004 Analysis of anti-interferon mechanism by HCV NS5A protein using HCV replicon system
- ウイルス学・肝臓病学
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Papers (792):
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中井 正人, 大原 正嗣, 坂本 直哉. 【チーム医療で取り組む肝胆膵疾患の栄養マネジメント】肝胆膵疾患に最適な栄養アセスメント法とは. 肝胆膵. 2024. 88. 1. 7-13
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Federico Rossari, Toshifumi Tada, Goki Suda, Shigeo Shimose, Masatoshi Kudo, Changhoon Yoo, Jaekyung Cheon, Fabian Finkelmeier, Ho Yeong Lim, José Presa, et al. α-FAtE: A new predictive score of response to atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma. International journal of cancer. 2023
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荘 拓也, 須田 剛生, 北潟谷 隆, 大原 正嗣, 中井 正人, 小川 浩司, 坂本 直哉. 【薬物療法によって変貌する肝細胞癌治療:2023 Update】Advanced stage肝細胞癌 Phase 3 HIMALAYA試験の結果とその解釈. 肝胆膵. 2023. 87. 4. 439-446
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荘 拓也, 須田 剛生, 大原 正嗣, 中井 正人, 小川 浩司, 出水 孝章, 目黒 高志, 中村 晃久, 高木 智史, 馬場 英, et al. IMbrave150基準外進行肝細胞癌に対するアテゾリズマブ+ベバシズマブ併用療法の治療効果と肝予備能変化. 肝胆膵. 2023. 87. 4. 508-509
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大原 正嗣, 小川 浩司, 長谷川 智子, 櫻井 菜々子, 中井 正人, 荘 拓也, 須田 剛生, 坂本 直哉. 北海道における肝炎医療コーディネーター養成研修会の実施状況の変遷に関する検討. 肝臓. 2023. 64. Suppl.3. A808-A808
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MISC (442):
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川久保 和道, 桒谷 将城, 杉浦 諒, 永井 孝輔, 岸 法磨, 米村 洋輝, 野澤 俊一郎, 坂本 直哉. 胆道疾患に対するInterventional EUSの現在、およびX線透視の活用-特集 低被ばく進むX線撮影装置. 映像情報medical : a monthly journal of medical imaging and information. 2023. 55. 2. 12-16
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山田 錬, 森川 賢一, 中村 晃久, 出水 孝章, 梅村 真知子, 大原 正嗣, 中井 正人, 荘 拓也, 須田 剛生, 小川 浩司, et al. 核酸アナログによるHBs抗原消失-Hepatitis B surface antigen (HBsAg) seroclearance by nucleos(t)ide analogs treatment-特集 B型肝炎診療の進歩. 消化器・肝臓内科 = Gastroenterology & hepatology / 消化器・肝臓内科編集委員会 編. 2022. 12. 2. 184-192
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須田 剛生, 川岸 直樹, 大原 正嗣, 中井 正人, 荘 拓也, 小川 浩司, 坂本 直哉. B型肝炎治療オーバービュー-Overview of treatment for hepatitis B-特集 B型肝炎診療の進歩. 消化器・肝臓内科 = Gastroenterology & hepatology / 消化器・肝臓内科編集委員会 編. 2022. 12. 2. 172-174
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桒谷 将城, 岸 法磨, 永井 孝輔, 川久保 和道, 坂本 直哉. 閉塞性黄疸のドレナージ,何を考える?-特集 胆道・膵疾患を診る : 早期診断・早期治療のために ; 胆膵実地診療のコツ. 内科 = Internal medicine : 臨床雑誌. 2022. 130. 1. 41-46
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須田 剛生, 小川 浩司, 坂本 直哉. 肝疾患における核酸医薬開発-Development of nucleic acid medicine in liver diseases-特集 革新的技術が変える肝疾患診療. 消化器・肝臓内科 = Gastroenterology & hepatology / 消化器・肝臓内科編集委員会 編. 2022. 11. 4. 489-493
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Professional career (1):
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