Rchr
J-GLOBAL ID:200901089088721437   Update date: Feb. 01, 2024

Saito Hiroyuki

サイトウ ヒロユキ | Saito Hiroyuki
Affiliation and department:
Homepage URL  (1): https://labo.kyoto-phu.ac.jp/bukka/index.html
Research field  (1): Pharmaceuticals - analytical and physicochemistry
Research keywords  (3): apolipoprotein ,  amyloid ,  lipid membrane
Research theme for competitive and other funds  (10):
  • 2022 - 2025 Mechanisms of aggregation and fibril formation of amyloidogenic proteins with amyloid cofactors
  • 2017 - 2021 Physicochemical mechanisms of amyloid fibril formation by amyloidogenic apolipoproteins
  • 2013 - 2017 Physicochemical mechanism on formation and metabolism of HDL particles by apolipoproteins
  • 2013 - 2015 Development of HDL-like lipid membrane discs for reconstitution of membrane proteins
  • 2010 - 2012 Structural basis of dysfunctional apolipoprotein-induced dyslipidemia
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Papers (107):
  • Norihiro Namba, Takashi Ohgita, Hiroko Tamagaki-Asahina, Kazuchika Nishitsuji, Toshinori Shimanouchi, Takeshi Sato, Hiroyuki Saito. Amyloidogenic 60-71 deletion/ValThr insertion mutation of apolipoprotein A-I generates a new aggregation-prone segment that promotes nucleation through entropic effects. Scientific Reports. 2023. 13. 1
  • Yuki Takechi-Haraya, Takashi Ohgita, Akiko Usui, Kazuchika Nishitsuji, Kenji Uchimura, Yasuhiro Abe, Ryuji Kawano, Monika I. Konaklieva, Mart Reimund, Alan T. Remaley, et al. Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability. 2023
  • Takashi Ohgita, Hiroki Kono, Izumi Morita, Hiroyuki Oyama, Toshinori Shimanouchi, Norihiro Kobayashi, Hiroyuki Saito. Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein. Scientific reports. 2023. 13. 1. 10885-10885
  • Yuki Takechi-Haraya, Takashi Ohgita, Mana Kotani, Hiroki Kono, Chihiro Saito, Hiroko Tamagaki-Asahina, Kazuchika Nishitsuji, Kenji Uchimura, Takeshi Sato, Ryuji Kawano, et al. Effect of hydrophobic moment on membrane interaction and cell penetration of apolipoprotein E-derived arginine-rich amphipathic α-helical peptides. Scientific Reports. 2022. 12. 1
  • Mizuka Nakao, Yuki Takechi-Haraya, Takashi Ohgita, Hiroyuki Saito, Yosuke Demizu, Ken-Ichi Izutsu, Kumiko Sakai-Kato. Analysis of the interaction of cyclosporine congeners with cell membrane models. Journal of pharmaceutical and biomedical analysis. 2022. 218. 114874-114874
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MISC (24):
  • 加藤くみ子, 八幡志穂, 原矢佑樹, 扇田隆司, 出水庸介, 斎藤博幸, 伊豆津健一. Nanoparticle tracking analysis for characterization of extracellular vesicles including exosomes. Pharm Tech Japan. 2022. 38. 2
  • 扇田隆司, 原矢佑樹, 岡田圭祐, 松井早希, 竹内美紗紀, 齋藤千尋, 西辻和親, 内村健治, 川野竜司, 長谷川功紀, et al. ポリプロリンIIヘリックス構造によるアルギニンペプチド細胞膜透過促進機構. 膜シンポジウム. 2020. 32
  • 小谷 真菜, 田村 悠樹, 扇田 隆司, 原矢 佑樹, 西辻 和親, 内村 健治, 長谷川 功紀, 加藤 くみ子, 赤路 健一, 斎藤 博幸. ApoE糖鎖結合ドメイン改変型両親媒性アルギニンペプチドの細胞膜透過機構. 日本薬学会年会要旨集. 2019. 139年会. 2. 249-249
  • 小谷真菜, 田村悠樹, 扇田隆司, 原矢佑樹, 西辻和親, 内村健治, 長谷川功紀, 加藤くみ子, 赤路健一, 斎藤博幸. ApoE糖鎖結合ドメイン改変型両親媒性アルギニンペプチドの細胞膜透過機構. 日本薬学会年会要旨集(CD-ROM). 2019. 139th. 2. ROMBUNNO.22PO-am128S-249
  • 田村悠樹, 小谷真菜, 扇田隆司, 原矢佑樹, 西辻和親, 内村健治, 長谷川功紀, 加藤くみ子, 赤路健一, 斎藤博幸. ApoE由来アルギニンペプチドの細胞膜透過における糖鎖依存性の評価. 日本膜学会年会講演要旨集. 2019. 41st
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Work history (6):
  • 2016/01 - 現在 Kyoto Pharmaceutical University Department of Biophysical Chemistry Professor
  • 2010/04 - 2015/12 Tokushima University Graduate School of Biomedical Sciences Professor
  • 2005/04 - 2010/03 Kobe Pharmaceutical University Department of Biophysical Chemistry Professor
  • 2004/01 - 2005/03 Children's Hospital of Philadelphia Research Associate
  • 1997/04 - 2003/12 National Institute of Health Sciences
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