Rchr
J-GLOBAL ID：200901089206660952
Update date: Feb. 29, 2024
Kubo Tai
クボ タイ | Kubo Tai
Affiliation and department：
Job title：
Science Fellow
Homepage URL (1)：
http://www.aist.go.jp/RESEARCHERDB/cgi-bin/worker_detail.cgi?call=namae&rw_id=T76634771
Research field (5)：
Pharmacology
, Applied biochemistry
, Functional biochemistry
, Structural biochemistry
, Neuroanatomy and physiology
Research keywords (9)：
in vitro evolution
, neurotransmitter receptor
, bioactive peptide
, peptide
, ion channel
, nerve transmitter substance receptor
, acetylcholine
, peptide
, physiologically active substance
Research theme for competitive and other funds (15)：
- 2018 - 2022 Allosteric modulators that recognize the transition-states of receptor channels
- 2016 - 2019 Discovery research of medium molecule drugs for cancer immunotherapy using in vitro molecular evolution technology
- 2014 - 2019 3D Active Site Science in Biology
- 2014 - 2017 Utilization of microenvironment of nanotubes in in-vitro evolution
- 2013 - 2016 Peptide drug discovery to identify the calcium channel subfamily by molecular evolutional technique
- 2010 - 2012 Search and analysis of bioactive peptides from a spider venom gland
- 2006 - 2007 Development of integrated model biological membranes on solid substrates
- 1994 - 1995 STRUCTURE AND FUNCTION ANALYSIS OF ATP-DEPENDENT K+CHANNEL AND SEROTONIN-SENSITIVE K+CHANNEL
- 1988 - 1991 Studies on the structure and function of neurotransmitter receptors and ionic channels
- 1983 - 1987 Studies on the Structure,Function and Gene Expression of Acetylcholine Receptors
- ナノバイオテクノロジー
- ペプチド高機能化技術の開発と創薬利用に関する研究
- 生理活性ペプチドの探索及び機能解析
- 神経機能タンパク質(受容体、イオンチャネル)の構造・機能・生理機能に関する研究
- Molecular basis of acetylcholine receptors and ion channel functions
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Papers (103)：
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Yue Yang, Tatsuya Arai, Daisuke Sasaki, Masahiro Kuramochi, Hidetoshi Inagaki, Sumiko Ohashi, Hiroshi Sekiguchi, Kazuhiro Mio, Tai Kubo, Yuji C. Sasaki. Real-time tilting and twisting motions of ligand-bound states of α7 nicotinic acetylcholine receptor. European Biophysics Journal. 2024. 53. 1-2. 15-25
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Kazuhiro Mio, Shoko Fujimura, Masaki Ishihara, Masahiro Kuramochi, Hiroshi Sekiguchi, Tai Kubo, Yuji C. Sasaki. Living-Cell Diffracted X-ray Tracking Analysis Confirmed Internal Salt Bridge Is Critical for Ligand-Induced Twisting Motion of Serotonin Receptors. International Journal of Molecular Sciences. 2021. 22. 10. 5285-5285
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Shoko Fujimura, Kazuhiro Mio, Masahiro Kuramochi, Hiroshi Sekiguchi, Keigo Ikezaki, Muneyo Mio, Kowit Hengphasatporn, Yasuteru Shigeta, Tai Kubo, Yuji C. Sasaki. Agonist and Antagonist-Diverted Twisting Motions of a Single TRPV1 Channel. The Journal of Physical Chemistry B. 2020. 124. 51. 11617-11624
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Kazuhiro Mio, Masaki Ishihara, Shoko Fujimura, Daisuke Sasaki, Shunsuke Nozawa, Kohei Ichiyanagi, Ryo Fukaya, Shin-ichi Adachi, Masahiro Kuramochi, Hiroshi Sekiguchi, et al. X-ray-based living-cell motion analysis of individual serotonin receptors. Biochemical and Biophysical Research Communications. 2020. 529. 2. 306-313
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K. Mio, S. Fujimura, M. Kuramochi, M. Ishihara, M. Honda, M. Mio, T. Kubo, H. Sekiguchi, Y. C. Sasaki. Toward understanding of internal motion measurement with quantum probe and cryo-EM. 2019. 44. 2. 210-215
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MISC (68)：
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K. Mio, K. Ikezaki, H. Sekiguchi, T. Baba, Y. Matsushita, T. Kubo, Y. C. Sasaki. Asymmetric rotational brownian motion on TRPV1 cation channel with X-ray single molecule technique. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S267-S267
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T. Kubo, T. Baba, S. Ohashi, H. Inagaki, K. Ikezaki, K. Mio, H. Sekiguchi, Y. C. Sasaki. PAMs modulate molecular dynamics of nAChR alpha 7: direct observation by DXT and electrophysiology. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S165-S165
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関口博史, 徳江真紀, 西野有里, 一柳光平, 久保泰, 宮澤淳夫, 八木直人, 佐々木裕次, 佐々木裕次. 高速1分子内ダイナミクス計測で捉えるアセチルコリン受容体・機能運動. 日本蛋白質科学会年会プログラム・要旨集. 2014. 14th
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関口博史, 徳江真紀, 西野有里, 一柳光平, 久保泰, 宮澤淳夫, 八木直人, 佐々木裕次, 佐々木裕次. 高速1分子内ダイナミクス計測で捉えるアセチルコリン受容体・機能運動. 日本蛋白質科学会年会プログラム・要旨集. 2014. 14th
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鈴木祥仁, 鈴木祥仁, 関口博史, 関口博史, 星指健太郎, 星指健太郎, 小林寿珠子, 小林寿珠子, CAI Weiyang, CAI Weiyang, et al. X線1分子追跡法を用いた膜タンパク質の高速1分子計測. 放射光. 2012. 25. 2
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Patents (24)：
Books (2)：
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『きちんとわかるナノバイオ』、第2章「生体分子モーターで駆動するナノアクチュエータ」、第8章「バイオセンサー」
白日社 2008
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『生体物理刺激と生体反応』、第2章「神経伝達物質」
フジテクノシステム社 2004
Works (3)：
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CREST 「高精度1分子内動画計測から見える生体分子構造認識プロセス」(代表 佐々木裕次) 「膜系1分子計測」
2008 - 2011
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科学技術振興調整費 新興分野人材育成 「産総研ナノバイオ人材養成ユニット」 (代表 湯元昇)
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科学技術振興調整費 知的基盤整備 「創薬及び生物研究情報基盤としての生体内ペプチドの多角的データベース化に関する研究」 (代表 南野直人)
Education (5)：
- Kyoto University Faculty of Engineering
- Kyoto University Graduate School of Engineering
- Kyoto University Graduate School of Medicine
- Kyoto University
- Kyoto University, Graduate School of Medicine and Faculty of Medicine
Professional career (1)：
Work history (14)：
- 2020 - 現在 National Institute of Advanced Industrial Science and Technology
- 2020/04 - 2022/03 Graduate School of Frontier Sciences, The University of Tokyo
- 2013/04 - 2020/03 National Institute of Advanced Industrial Science and Technology (AIST) Molecular Profiling Research Center Deputy Director
- 2007/04 - 2015/03 Gifu University United Graduate School of Drug Discovery and Medical Information Sciences Visiting Professor
- 2010 - 2013 National Institute of Advanced Industrial Science and Technology (AIST) Evaluation Department Principal Reviewer
- 2009 - 2010 National Institute of Advanced Industrial Science and Technology (AIST) Neuroscience Research Instutite Director
- 2005 - 2009 National Institute of Advanced Industrial Science and Technology
- 2001 - 2005 National Institute of Advanced Industrial Science and Technology
- 1997 - 2001 工業技術院 生命工学工業技術研究所 主任研究官 研究グループリーダー
- 1992 - 1997 財団法人 国際高等研究所 研究員
- 1985 - 1992 Kyoto University Faculty of Medicine
- 1984 - 1985 日本学術振興会奨励研究員(京都大学医学部)
- New York State Psychiatric Institute, Research Scientist
- Howard Hughes Medical Institute, Research Associate
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Association Membership(s) (4)：
THE JAPANESE PEPTIDE SOCIETY
, International Society on Toxinology
, Biophysical Society
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
