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J-GLOBAL ID：200901089463368472   Update date: Apr. 15, 2024

Higuchi Yoshiki

ヒグチ ヨシキ | Higuchi Yoshiki
Affiliation and department：
University of Hyogo Graduate School of Science

About University of Hyogo Graduate School of Science


Job title： Specially Appointed Professor of University of Hyogo
Homepage URL  (1)： http://www.sci.u-hyogo.ac.jp/life/biophys1/index-j.html
Research field  (4)： Molecular biology ,  Biophysics ,  Structural biochemistry ,  Biochemistry
Research keywords  (5)： hydrogenase ,  構造生物学 ,  タンパク質結晶学 ,  Structural Biology ,  Protein Crystallography
Research theme for competitive and other funds  (35)：
  • 2019 - 2024 Structural basis of reaction mechanism and proton pathway of [NiFe]-hydrogenase
  • 2018 - 2023 high speed and local transfer hydrogen and electrons
  • 2017 - 2019 Reaction mechanism of [FeFe] hydrogenases
  • 2016 - 2018 Activity inhibition mechanism of [NiFe] hydrogenase by oxidative modification of active site cysteine ligand
  • 2012 - 2018 Structural Basis of Biological System in Hydrogen Energy Metabolism
Show all
Papers (222)：
  • Ami Kobayashi, Midori Taketa, Keisei Sowa, Kenji Kano, Yoshiki Higuchi, Hideaki Ogata. Structure and function relationship of formate dehydrogenases: an overview of recent progress. IUCrJ. 2023. 10. 5. 544-554
  • Takeshi Hiromoto, Koji Nishikawa, Seiya Inoue, Hideaki Ogata, Yuta Hori, Katsuhiro Kusaka, Yu Hirano, Kazuo Kurihara, Yasuteru Shigeta, Taro Tamada, et al. New insights into the oxidation process from neutron and X-ray crystal structures of an O2-sensitive [NiFe]-hydrogenase. Chemical Science. 2023. 35. 14. 9306-9315
  • Seiji Negoro, Naoki Shibata, Dai-ichiro Kato, Yusuke Tanaka, Kengo Yasuhira, Keisuke Nagai, Shohei Oshima, Yoko Furuno, Risa Yokoyama, Kaito Miyazaki, et al. X-ray crystallographic and mutational analysis of the NylC precursor: Catalytic mechanism of autocleavage and substrate hydrolysis of nylon hydrolase. The FEBS Journal. 2023
  • Catharina J. Kulka-Peschke, Anne-Christine Schulz, Christian Lorent, Yvonne Rippers, Stefan Wahlefeld, Janina Preissler, Claudia Schulz, Charlotte Wiemann, Cornelius C. M. Bernitzky, Chara Karafoulidi-Retsou, et al. Reversible Glutamate Coordination to High-Valent Nickel Protects the Active Site of a [NiFe] Hydrogenase from Oxygen. Journal of the American Chemical Society. 2022. 144. 37. 17022-17032
  • Naoki Shibata, Yoshiki Higuchi, Bernhard Kräutler, Tetsuo Toraya. Structural Insights into the Very Low Activity of the Homocoenzyme B 12 Adenosylmethylcobalamin in Coenzyme B 12 -Dependent Diol Dehydratase and Ethanolamine Ammonia-Lyase. Chemistry - A European Journal. 2022. e202202196. 65. e202202196
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MISC (44)：
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Books (28)：
  • Hydrogenomics: The Science of Fully Utilizing Hydrogen
    2023
  • 生命金属ダイナミクス : 生体内における金属の挙動と制御
    エヌ・ティー・エス 2021 ISBN:9784860437060
  • イメージング時代の構造生命科学 : 細胞の動態、膜のないオルガネラ、分子の構造変化をトランススケールに観る
    羊土社 実験医学増刊 2020 ISBN:9784758103855
  • 進化を続ける構造生物学
    化学同人 2014 ISBN:9784759815153
  • 構造生命科学で何がわかるのか,何ができるのか : 最先端のタンパク質解析技術から構造情報の活用事例,創薬展開まで
    羊土社 実験医学増刊 2014 ISBN:9784758103398
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Lectures and oral presentations  (25)：
  • Structural Studies on [NiFe]-hydrogenases-Role of water/proton-network for O2-stability
    (3rd International Solar Fuels Conference (ISF-3) and International Conference on Artificial Photosynthesis-2019 (ICARP2019) 2019)
  • Role of water network for O2-stability of [NiFe]-hydrogenases
    (12th International Hydrogenase Conference 2019 2019)
  • Structural study on [NiFe]-hydrogenases
    (I2CNER International Workshop, Catalysis for Future Energy Technologies 2019 2019)
  • Aiming Towards Comprehensive Structural Chemistry on [NiFe]-hydrogenases (Molecular Mechanism of O2-tolerance)
    (3rd International Symposium and Workshop on Functional Genomic and Structural Biology (FGSB2018) 2018)
  • Crystallographic Studies of [NiFe]-hydrogenases
    (8th Asian Biological Inorganic Chemistry Conference (AsBIC8) 2016)
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Professional career (1)：
  • Doctor of Science (Osaka University)
Committee career (5)：
  • 2012/01 - 現在 The Protein Society Editorial Advisory Board of Protein Science
  • 2003 - 現在 The Japanese Biochemical Society Councillor
  • 2010/04 - 2023/03 The Crystallographic Society of Japan Councillor
  • 1996/04 - 1998/03 The Biophysical society of Japan committee member of the editorial board
  • 1994/04 - 1996/03 The Crystallographic Society of Japan committee member of the editorial board
Awards (5)：
  • 2022/12 - Hyogo Prefecture Hyogo Prefecture Education Achievement Award (Governor Commendation) university education
  • 2020/04 - Ministry of Education, Culture, Sports, Science and Technology Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology Structural basis of the mechanism of hydrogen metabolism for hydrogenases
  • 2017/11 - Hyogo prefecture Hyogo Preecture Science Award Structural studies on hydrogenases
  • 2014/10 - Iue Memorial Foundation 38th Iue Culture Prize X-ray structural study and application for the proteins
  • 1999/11 - The Crystallographic Society of Japan 1999 Award of Japan Crystallographic Society X-ray Structure Analysis of Hydrogenase
Association Membership(s) (6)：
Protein science Society of Japan ,  The Biophysical Society of Japan ,  Tha Japanese Society for Synchrotron Radiation Research ,  The japanese Biochemical Society ,  The Chemical Society Of Japan ,  The Crystallographic Society of Japane
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