Rchr
J-GLOBAL ID:200901089588771570   Update date: Feb. 01, 2024

Kobuchi Hirotsugu

コブチ ヒロツグ | Kobuchi Hirotsugu
Affiliation and department:
Job title: Senior Assistant Professor
Research field  (5): Tumor biology ,  Pharmaceuticals - chemistry and drug development ,  Physiology ,  Molecular biology ,  Medical biochemistry
Research keywords  (5): 腫瘍学 ,  創薬化学 ,  分子細胞生物学 ,  生化学 ,  Biochemistry
Research theme for competitive and other funds  (10):
  • 2022 - 2025 骨変性部位の目印「dig-hereシグナル」を認識する破骨細胞特異的受容体の探索
  • 2021 - 2024 Analysis of cell death induction and antitumor effect by suppression of the expression of ABC transporter
  • 2019 - 2022 The role of pattern recognition receptors in osteoclast differentiation and function
  • 2019 - 2022 深部・転移がんへのRadio-induced photodynamic (RIPD) - Theranosticsを実現する89Zr標識・抗体担持生分解性キャリアの開発
  • 2016 - 2019 深部・転移がんへのRadio-induced photodynamic (RIPD) - Theranosticsを実現する89Zr標識・抗体担持生分解性キャリアの開発
Show all
Papers (61):
  • Haruna Harada, Koko Moriya, Hirotsugu Kobuchi, Naotada Ishihara, Toshihiko Utsumi. Protein N-myristoylation plays a critical role in the mitochondrial localization of human mitochondrial complex I accessory subunit NDUFB7. Scientific Reports. 2023. 13. 1. 22991-22991
  • Melissa Siaw Han Lim, Takashi Ohtsuki, Fumiaki Takenaka, Kazuko Kobayashi, Masaru Akehi, Hirotaka Uji, Hirotsugu Kobuchi, Takanori Sasaki, Eiichi Ozeki, Eiji Matsuura. A Novel 89Zr-labeled DDS Device Utilizing Human IgG Variant (scFv): “Lactosome” Nanoparticle-Based Theranostics for PET Imaging and Targeted Therapy. Life. 2021. 11. 2. 158-186
  • Melissa Siaw Han Lim, Yuki Nishiyama, Takashi Ohtsuki, Kazunori Watanabe, Hirotsugu Kobuchi, Kazuko Kobayashi, Eiji Matsuura. Lactosome-Conjugated siRNA Nanoparticles for Photo-Enhanced Gene Silencing in Cancer Cells. Journal of pharmaceutical sciences. 2021. 110. 4. 1788-1798
  • Utsumi T, Matsuzaki K, Kiwado A, Tanikawa A, Kikkawa Y, Hosokawa T, Otsuka A, Iuchi Y, Kobuchi H, Moriya K. Identification and characterization of protein N-myristoylation occurring on four human mitochondrial proteins, SAMM50, TOMM40, MIC19, and MIC25. PloS one. 2018. 13. 11. e0206355
  • 竹中文章, 小林和子, 木村俊作, 小関英一, 大槻高史, 小渕浩嗣, 松浦栄次. 89Zr標識ヒト抗体バリアントと新規DDSキャリアによるTheranostics技術. Drug Delivery System. 2018. 33. 3. 214-222
more...
MISC (9):
  • 山田 勝彦, 山本 真司, 竹原 良記, 小渕 浩嗣, 吉岡 保, 内海 耕慥, 玉井 浩. ビタミンE及びコレステロールのコハク酸エステルによるヒト前骨髄性白血病細胞(HL-60)のアポトーシス誘導とその比較. ビタミン. 2002. 76. 3. 158-158
  • S Roy, CK Sen, H Kobuchi, L Packer. Antioxidants regulate agonists-induced cell adhesion molecule expression and function. FASEB JOURNAL. 1999. 13. 7. A1581-A1581
  • L Packer, T Bito, E Cossins, H Kobuchi, H Moini, Y Noda, G Rimbach, S Roy, J Vaya, F Virgili. French Maritime Pine bark extract: Antioxidant activity and effects on regulation of nitric oxide metabolism and cell adhesion. FASEB JOURNAL. 1999. 13. 4. A546-A546
  • L Packer, F Virgill, H Kobuchi, R Lee, E Cossins. Effect of polyphenols extracted from pine bark (pycnogenol) on nitric oxide metabolism and their role in the antioxidant network: Development of tools for the management of free-radical associated diseases?. FASEB JOURNAL. 1998. 12. 5. A814-A814
  • S Roy, CK Sen, H Kobuchi, L Packer. Regulation of phorbol ester induced adhesion of human jurkat T-cells to endothelial cells by the thiol antioxidant alpha-lipoate. FASEB JOURNAL. 1998. 12. 5. A772-A772
more...
Patents (3):
  • 修飾RNAを含有する分子集合体及びそれを用いたRNA送達システム
  • ポリ乳酸修飾RNAを有する分子集合体及びそれを用いたRNA送達システム
  • Molecular assembly containing modified RNA, and RNA delivery system using same.
Books (15):
  • 生物学に関する試験研究論叢 23
    2008
  • 両備てい園記念財団 平成18年度 研究報告書
    2008
  • 浜崎癌研究助成 平成18年度 研究報告書
    2007
  • 財団法人ウエスコ学術振興財団 平成17年度(2005〜2006)研究助成報告
    2006
  • 財団法人ウエスコ学術振興財団 平成16年度(2004〜2005)研究助成報告
    2005
more...
Lectures and oral presentations  (59):
  • 効率的なsiRNAの光依存的細胞内送達能を持つ生分解性ナノキャリアの開発
    (第44回日本バイオマテリアル学会 2022)
  • N-myristoylation dependent mitochondrial targeting of NDUFB7, an accessory subunit of mitochondrial respiratory complex I
    (2021)
  • N-ミリストイル化依存的にミトコンドリアに特異的に局在するタンパク質NDUFB7の発見
    (第62回 日本生化学会 中国・四国支部例会 2021)
  • Identification of N-myristoylated protein specifically localized to mitochondria by protein N-myristoylation
  • N-ミリストイル化されたミトコンドリアタンパク質の探索
    (第61回 日本生化学大会中四国支部例会 2020)
more...
Education (5):
  • 1991 - 1995 Okayama University Medical School
  • - 1995 Okayama University
  • 1988 - 1991 Kochi Medical School
  • 1984 - 1988 Kochi University
  • - 1988 Kochi University Faculty of Agriculture
Professional career (1):
  • Ph. D. (Okayama University)
Work history (11):
  • 2021/04 - 現在 Okayama University
  • 2005/04 - 現在 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Cell Chemistry Assistant Professor
  • 2001/04 - 2005/03 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Cell Chemistry Assistant Professor
  • 2001 - 2005 Senior Assistant Professor,Okayama University
  • 2005 - - Senior Assistant Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University
Show all
Awards (1):
  • 2002/07 - 日本生化学会 中四国支部奨励賞 志賀毒素のアポトーシス誘導機構におけるセラミドの関与
Association Membership(s) (3):
日本分子生物学会 ,  日本生化学会 ,  日本酸化ストレス学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page