Rchr
J-GLOBAL ID：200901089824459567   Update date: Apr. 09, 2024

Nogi Terukazu

ノギ テルカズ | Nogi Terukazu
Affiliation and department：
Yokohama City University

About Yokohama City University


Homepage URL  (1)： http://www-mls.tsurumi.yokohama-cu.ac.jp/xtal-mls/members/nogi/
Research field  (1)： Structural biochemistry
Research keywords  (4)： 膜内タンパク質切断 ,  Development of protein production system ,  Transmembrane signaling ,  Structural biology
Research theme for competitive and other funds  (8)：
  • 2022 - 2026 Molecular mechanism of substrate selection and cleavage by intramembrane protease in lipid bilayer
  • 2019 - 2022 Examination of substrate specificity in the regulated intramembrane proteolysis
  • 2017 - 2019 動物細胞発現系と化学合成の融合による1回膜貫通型受容体への部位特異的標識導入
  • 2014 - 2017 Development of therapy methodology for neuronal regeneration using neural circuit formation factor LOTUS
  • 2010 - 2012 Structural basis for cell signaling mediated by lipoprotein receptors
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Papers (48)：
  • Tatsuhiko Yokoyama, Yutaro Yamagata, Saisei Honna, Shinya Mizuno, Shizuka Katagiri, Rika Oi, Terukazu Nogi, Yohei Hizukuri, Yoshinori Akiyama. S2P intramembrane protease RseP degrades small membrane proteins and suppresses the cytotoxicity of intrinsic toxin HokB. mBio. 2023
  • Renoma Takeda, Rie Ishii, Shumaia Parvin, Aki Shiozawa, Terukazu Nogi, Yukio Sasaki. Novel presynaptic assay system revealed that metformin ameliorates exaggerated synaptic release and Munc18-1 accumulation in presynapses of neurons from Fragile X syndrome mouse model. Neuroscience letters. 2023. 810. 137317-137317
  • Yuriko Adachi, Mika K Kaneko, Yukinari Kato, Terukazu Nogi. Recombinant production of antibody antigen-binding fragments with an N-terminal human growth hormone tag in mammalian cells. Protein expression and purification. 2023. 208-209. 106289-106289
  • Tsubasa Tanaka, Toru Ekimoto, Meri Nagatomo, Makiko Neyazaki, Erena Shimoji, Tsutomu Yamane, Sakura Kanagawa, Rika Oi, Emiko Mihara, Junichi Takagi, et al. Hybrid in vitro/in silico analysis of low-affinity protein-protein interactions that regulate signal transduction by Sema6D. Protein science : a publication of the Protein Society. 2022. 31. 11. e4452
  • Yuki Imaizumi, Kazunori Takanuki, Takuya Miyake, Mizuki Takemoto, Kunio Hirata, Mika Hirose, Rika Oi, Tatsuya Kobayashi, Kenichi Miyoshi, Rie Aruga, et al. Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP. Science advances. 2022. 8. 34. eabp9011
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MISC (58)：
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Books (2)：
  • 日本の結晶学(II)
    2014
  • Frontiers of Protein Crystals
    2013
Lectures and oral presentations  (6)：
  • 細胞表層ストレス応答に関わる大腸菌膜内切断プロテアーゼRsePの構造生物学的解析
    (第93回日本生化学会大会・シンポジウム「TAシステムを介した細胞の休眠と覚醒:生化学と一細胞解析の融和を目指したアプローチ」 2020)
  • Low-affinity but specific interactions between semaphorin-plexin pairs
    (The 56th Annual Meeting of The Biophysical Society of Japan 2018)
  • Understanding of ligand capture and release mechanism in the LDLR family members based on the crystal structure of the ApoER2 ectodomain in complex with the reelin R56 fragment
    (ConBio2017 2017)
  • Crystal structure of the endocytic receptor ApoER2 in the ligand-bound state
    (2017)
  • Structural study on lipoprotein uptake mechanism in the LDLR family
    (2016)
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Works (5)：
  • 構造安定化変異を導入した組換えG蛋白質共役型受容体(PAR-4)の大量発現
    2005 -
  • 膜内領域におけるタンパク質切断(RIP)に関する構造生物学的研究
    2005 -
  • 血小板トロンビン受容体の立体構造解析
    2005 -
  • Site-2プロテアーゼの立体構造解析と膜内タンパク質切断の反応機構解析
    2005 -
  • 細胞外リガンドと受容体の相互作用を“見る”-そのシグナリングにおける構造的側面
Education (5)：
  • - 2001 Kyoto University Graduate School, Division of Natural Science
  • - 2001 Kyoto University Graduate School, Division of Natural Science Department of Chemistry
  • 2001 - 京都大学 理学研究所 化学専攻
  • - 1996 Kyoto University
  • 1996 - Kyoto University
Professional career (1)：
  • Doctor(Science) (Kyoto University)
Work history (7)：
  • 2013/04 - 現在 Yokohama City University Graduate school of Medical Life Science Associate professor
  • 2011/04 - 2013/03 Yokohama City University Graduate School of Nanobioscience, Graduate
  • 2007/04 - 2011/03 Osaka University Institute for Protein Research
  • 2004/02 - 2007/03 Osaka University Institute for Protein Research
  • 2002/05 - 2004/01 マックスプランク生物物理学研究所分子膜生物学研究部門 博士研究員(Humboldt Research Fellow)
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Committee career (12)：
  • 2024/04 - 現在 日本結晶学会 AsCA評議員
  • 2024/04 - 現在 日本結晶学会 監査役
  • 2022/04 - 現在 日本結晶学会 評議員
  • 2013/08 - 現在 日本蛋白質科学会 男女共同参画WG
  • 2022/06 - 2024/06 日本蛋白質科学会 執行役員
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Awards (3)：
  • 2021/11 - 一般社団法人日本結晶学会 日本結晶学会賞・学術賞 生体膜上で形成される低親和性蛋白質間相互作用の構造生物学的研究
  • 2006 - 平成18年度日本結晶学会賞・進歩賞
  • 2002 - 第19回(平成14年度)留学補助金
Association Membership(s) (4)：
The Biophysical Society of Japan ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN
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