Yonemitsu Yoshikazu

2015 - 2020 Development of Innovative Treatment Targeting the Sphere Formation Mechanism Involving Cancer Stem Cells

2016 - 2018 Drug screening for refractory malignant tumors based on sphere destructive potency

2016 - 2018 Development of the the innovative treatment and the proposal of the Self-niche hypothesis in refractory cancer

2014 - 2018 Study regarding pathophysiological significance of failure of vessel stability-induced system in diabetes mellitus-associated microvasculopathy

2014 - 2018 Building a nursing research and educational model for Evidence-Based Nursing practice

2013 - 2016 Development of a novel therapeutic approach based on the mechanism of tumor dissemination

2013 - 2016 Development of the innovative hybrid artificial liver with establishment of the hepatocyte strain from human iPS cells

2013 - 2016 Establishment of genetically engineered mouse creation foundation based on a new concept

2012 - 2015 Pre-clinical application of an innovative therapy, "BioKnife", to malignant pleural mesothelioma

2012 - 2015 Microenvironment in hepatocellular carcinoma

2011 - 2015 The establishment of the novel immunotherapy for neuroblastoma using transgenic mouse

2011 - 2013 The basic research for the novel treatment for under active bladder -focusing on the construction of troponin system in smooth muscle-

2010 - 2012 Study of novel pathogenesis and its availability of therapeutic target for diabetes-associated microangiopathy

2010 - 2011 Development of'BioKnife', a uPA-targeted oncolytic Sendai virus to treat intractable malignancies.

2009 - 2011 A novel treatment strategy for digestive system cancer against angiogenic signal in tumor stroma using nanosize particle.

2009 - 2011 Development of"immunostimulatory virotherapy"to treat various malignancies

2009 - 2010 染色体遺伝子へ影響を与えない全く新しい遺伝子操作マウス創出技術の確立

2008 - 2010 Signaling cross-talk between G protein-coupled receptor and tetraspanin in tumor inflammatory microenvironment

2008 - 2010 Development of anti-tumor gene therapy for retinoblastoma using Sendai virus vector and IFNB gene.

2007 - 2009 Development of local regulation strategy for malignant pleural mesothelioma

2006 - 2008 Dendritic cell-based immunotherapy for pediatric solid malignant tumor using the novel vector

2006 - 2007 Pathophysiological Mechanisms of Angiogenesis-Related Diseases

2006 - 2007 The role of innate immunity in choroidal neovascularization

2005 - 2006 Clinicopathyological and molecular studies for arising and development of lung Adenocarcinoma

2005 - 2006 Isolation and identification of tissue stem cell for clinical application

2005 - 2006 血管内皮細胞におけるCaspr3の病理学的・生物学的特性に関する萌芽的研究

2005 - 2006 新規受容体型PTPによる細胞機能変換の分子機構に関する萌芽的研究

2004 - 2006 Moleculo-pathological Study on the Homeostatic and Deregulated Mechanisms of Vascular Remodeling

2004 - 2005 Basic Research for Complex Molecular Mechanisms of the Process of the Functional Angiogenesis : toward the development of technologies controlling the molecular target of pathological angiogenesis.

2004 - 2005 細胞質転写型新規国産ベクターを用いた染色体非傷害型免疫再構築遺伝子治療法の開発

2004 - 2005 結膜下組織への遺伝子導入法の確立と治療への応用

2003 - 2005 Gene Therapy for Retinal Degeneration using Home-grown Gene Transfer Vectors-Aim for Clinical Trial-

2002 - 2004 Moleculo-Pathological studies on intracellular cross-talk signal in angiogenic process.

2002 - 2004 新規遺伝子導入ベクターを用いた慢性関節リウマチの治療法の開発

2002 - 2003 Hierarchical Regulation of Multiple Angiogenic Growth Factors During 'Functional' Angiogenesis In Vivo

2002 - 2003 Development of gene therapy using a novel domestic viral vector.

2001 - 2003 Molecular Pathophysiological Study on Endothelial Function Occurring during Vascular Remodeling

2001 - 2002 Essential role of monocyte chemoattractant protein-1 (MCP1) in development of restenotic changes (neointimal hyperplasia and constrictive remodeling) after balloon angioplasty in hypercholesterolemic rabbits

2001 - 2002 PEDFによる血管新生阻害機構の分子病理学的解析と治療への応用

2000 - 2002 Deveelopment of Novel Gene Theray Strategies Using Recombinant Sendai Virus.

2000 - 2001 Role of human cytomegalovirus infection and the expression of immediate early gene products (CMV-IE) in the pathogenesis of vascular lesion formations

2000 - 2000 動脈硬化発生・進展における血管内皮細胞機能に関する分子病理学的研究

1999 - 2000 Regulation of Vascular Remodeling by Gene Transfer and Its Clinical Application : Exploration of Novel Gene Transfer Vector and Gene Therapy for Atherosclerosis, Angiogenic Diseases and Organ Infarction

1998 - 2000 Molecular pathobiological Study on Endothelial Function Ocurring during Vascular Remodeling

1999 - 1999 動脈硬化発生・進展における血管内皮細胞機構に関する分子病理学的研究

ヒトサイトメガロウイルス感染による血管炎発生機序に関する研究

難治性循環器疾患,呼吸器疾患に対する遺伝子治療学の確立

動脈硬化の分子病理学的解析

Molecular analyses for Human Cytomegalovirus induced vasculitis

Development of Gene therapy strategies for intraetable cardiovascular and respiratoy diseases.

Molccular pathological analyses for atheroclerosis