Mizukami Yusuke

ミズカミユウスケ | Mizukami Yusuke

Affiliation and department：
Homepage URL (1)： http://www.asahikawa-med.ac.jp/dept/mc/imed3/

Research field (3)： Gastroenterology , Tumor biology , Genomics

Research keywords (7)： Intraductal Papillary Mucinous Neoplasm , pancreatic cancer , tumor biology , Cancer Genetics , Gastroenterology , Clonal evolution , Biomarker

Research theme for competitive and other funds (28)：

2023 - 2026 Prediction of postoperative recurrence of pancreatic cancer by monitoring genomic abnormalities in the whole pancreas
2023 - 2026 血漿遊離核酸マルチレイヤー解析の自己免疫性膵炎診断・活動性評価への応用
2022 - 2026 Strategy for an early diagnosis by modeling the developmental and evolutionary paths of human pancreatic cancer
2022 - 2025 肺がん背景肺に潜むゲノム・エピゲノム異常の徹底的マッピングによる発がん機序の解明
2022 - 2025 TP53-RAS/RAF経路のクロストークに基づく局所進行直腸癌の術前治療戦略

2021 - 2024 The clinical applications of long non-coding RNA and extracellular vesicles to diagnosis and therapy for pancreatic cancer

2021 - 2024 Study on the mechanism of oncogene activation by structural variants in cancer genome

2020 - 2023 Early diagnosis of pancreatic cancer based on diversity of field defect and molecular genetic approach

2020 - 2023 ドライバー変異が惹起する発癌経路に基づいた血中新規バイオマーカーの探索

2020 - 2023 膵管内乳頭粘液性腫瘍の進展を担う分子機構の解明

2020 - 2023 Distribution and clonality of multiple intraductal neoplasms of the pancreas evaluated by morphology

2017 - 2020 Genetic alterations in early-onset pancreatic cancer

2017 - 2020 Diversity of molecular paths during pancreatic carcinogenesis

2015 - 2018 Monitoring of Emerging Resistance of Lung Cancer using Liquid Biopsy

2015 - 2018 Pancreatic-Intestinal Crosstalk: a novel approach to elucidate the tumorigenic process of PDAC

2015 - 2017 Endoscopic ultrasound-guided through-the-needle-biopsy for the diagnosis of pancreatic cystic neoplasms

2014 - 2017 Cryo-immunology; booster effects of cryotherapy on the anti-tumor immune response

2013 - 2017 Development of novel therapy based on epigenetic alterations in Barrett's esophagus

2013 - 2016 Primary tumor culture for personalized medicine

2013 - 2016 Non-invasive modality for diagnosis of pancreatic neoplasm

2013 - 2015 Non-invasive identification and monitoring of cancer using hair follicle gene expression profiling

2010 - 2012 Role of bone marrow-derived cells during pancreatic tumorigenesis

2007 - 2011 腫瘍血管リモデリング誘導による新規難治がん克服技術の研究開発

2008 - 2010 Overcome to avoidance from the anti-leukemia immunity by using combination therapy with HSP and dendritic cells targeted to both tumor and tumor angiogenesis

2006 - 2007 血管内皮前駆細胞を用いた細胞遺伝子治療の開発〜がん治療への応用〜

2006 - 2007 ヒト血管内皮前駆細胞の可塑性に起因するがん微小環境の異常とその制御

血管新生を標的とした癌治療の開発

Therapeutic targeting of tumor angiogenesis

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Papers (200)：

Yuko Omori, Shuichi Aoki, Yusuke Ono, Takashi Kokumai, Shingo Yoshimachi, Hideaki Sato, Akiko Kusaka, Masahiro Iseki, Daisuke Douchi, Takayuki Miura, et al. Clonal analysis of metachronous double biliary tract cancers. The Journal of pathology. 2024. 263. 1. 113-127
Hiroki Sato, Hidemasa Kawabata, Hidetaka Iwamoto, Tetsuhiro Okada, Shugo Fujibayashi, Kenji Takahashi, Yohei Kitano, Takuma Goto, Yusuke Mizukami, Toshikatsu Okumura, et al. New gel immersion endoscopic ultrasonography technique for accurate periampullary evaluation. Surgical endoscopy. 2024
Kenji Takahashi, Tatsutoshi Inuzuka, Yuta Shimizu, Kazuki Sawamoto, Kenzui Taniue, Yusuke Ono, Fumi Asai, Kazuya Koyama, Hiroki Sato, Hidemasa Kawabata, et al. Liquid Biopsy for Pancreatic Cancer by Serum Extracellular Vesicle-Encapsulated Long Noncoding RNA HEVEPA. Pancreas. 2024
Hiroyuki Hato, Atsushi Kaneko, Chiho Maeda, Ken-ichiro Sakata, Yusuke Ono, Yusuke Mizukami, Toru Kono, Yoshimasa Kitagawa. Comparison between hangeshashinto and dexamethasone for IL-1α and β-defensin 1 production by human oral keratinocytes. Journal of Oral Biosciences. 2024
Masayo Yamamoto, Motohiro Shindo, Takuya Funayama, Chihiro Sumi, Takeshi Saito, Yasumichi Toki, Mayumi Hatayama, Yusuke Ono, Kazuya Sato, Yusuke Mizukami, et al. Monitoring mutant KRAS in plasma cell-free DNA can predict disease progression in a patient with multiple myeloma: A case report. Clinica chimica acta; international journal of clinical chemistry. 2023. 551. 117590-117590

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MISC (242)：

大森優子, 水上裕輔, 古川徹. Low-grade PanINは膵癌の前駆病変なのか? Low-grade PanINは胃型IPMNの前駆病変なのか?. 胆と膵. 2023. 44. 4. 339-344
Yuko Omori, Yusuke Ono, Takashi Kokumai, Fumiko Date, Ryota Higuchi, Goro Honda, Yusuke Mizukami, Takanori Morikawa, Michiaki Unno, Toru Furukawa. Molecular Phenotyping and the Combinatorial System by the Number of Accumulated Gene Alterations of Intraductal Papillary Mucinous Neoplasms Stratifies the Risk of Invasion and Outcome: New Insight for Management Strategy. LABORATORY INVESTIGATION. 2023. 103. 3. S1520-S1520
河端秀賢, 高橋賢治, 水上裕輔. 【膵癌・胆道癌2023(上)膵癌編-基礎・臨床の最新研究動向-】上皮性腫瘍嚢胞性膵腫瘍膵管内乳頭粘液性腫瘍(IPMN) 診断由来癌と併存癌. 日本臨床. 2023. 81. 増刊2 膵癌・胆道癌2023(上)膵癌編. 276-288
石黒達也, 河端秀賢, 小山一也, 梶浦麻未, 佐藤裕基, 岡田哲弘, 岩本英孝, 高橋賢治, 北野陽平, 藤谷幹浩, et al. EUS下胆道ドレナージにおけるステント迷入への対策. 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集. 2023. 133rd-127th
羽藤裕之, 金子篤, 前田知歩, 坂田健一郎, 小野裕介, 水上裕輔, 水上裕輔, 河野透, 北川善政. ヒト口腔粘膜上皮細胞のIL-1αおよびβ-defensin1の産生に対する半夏瀉心湯とデキサメタゾンの作用比較. 日本口腔科学会学術集会プログラム・抄録集. 2023. 77th

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Patents (5)：

Education (1)：

1987 - 1993 Asahikawa Medical University School of Medicine

Committee career (4)：

2022/01 - 現在 The Japanese Cancer Association Board of Councilors
2022/01 - 現在 The Japanese Society of Gastroenterology Board of Councilors
2019/06 - 現在日本消化器病学会機関誌編集委員会
2020/01 - 2024/12 Japan Pancreas Society Board Certified Trainer

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