HIROYUKI YAMAZAKI

ヤマザキヒロユキ | HIROYUKI YAMAZAKI

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Gunma University Graduate School of Medicine

Homepage URL (1)： http://neuro.dept.med.gunma-u.ac.jp/

Research field (3)： Pharmacology , Neuroscience - general , Neuropathology

Research keywords (12)：エピジェネティクス , 自閉症 , 樹状突起スパイン , 細胞培養 , 行動解析 , アルツハイマー病 , Ca2+/calmodulin-dependent protein kinase II , ZMYND8/Spikar , drebrin , actin cytoskeleton , synapse , dendritic spine

Research theme for competitive and other funds (7)：

2023 - 2027 エピジェネティクス制御に着目したストレス適応の分子基盤の解明
2017 - 2020 Actin-based model of synaptic plasticity
2014 - 2017 Role of spine-resident transcriptional coactivator in dendritic spine formation
2009 - 2010 A novel mechanism of dendritic spine formation by synapse-resident transcriptional coactivator
2006 - 2007 新規転写調節因子による樹状突起スパイン形成機構

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Papers (44)：

Hiroyuki Yamazaki, Tomoaki Shirao. The Nuclear Export and Dendritic Spine Localization of Transcriptional-regulator Spikar/ZMYND8. The Kitakanto Medical Journal. 2023. 73. 4. 293-298
Hiroyuki Yamazaki, Noriko Koganezawa, Hideaki Yokoo, Yuko Sekino, Tomoaki Shirao. Super-resolution imaging reveals the relationship between CaMKIIβ and drebrin within dendritic spines. Neuroscience Research. 2023
Min-Jue Xie, Hideshi Yagi, Tokuichi Iguchi, Hiroyuki Yamazaki, Kenji Hanamura, Hideo Matsuzaki, Tomoaki Shirao, Makoto Sato. Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner. Neuroscience Research. 2022. 185. 1-10
Kazuyuki Togo, Hayato Fukusumi, Tomoko Shofuda, Hiroshi Ohnishi, Hiroyuki Yamazaki, Mariko Kato Hayashi, Nana Kawasaki, Nobuyuki Takei, Takanobu Nakazawa, Yumiko Saito, et al. Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro. Molecular Brain. 2021. 14. 1. 149-149
Paloma Alvarez-Suarez, Natalia Nowak, Anna Protasiuk-Filipunas, Hiroyuki Yamazaki, Tomasz J. Prószyński, Marta Gawor. Drebrin Regulates Acetylcholine Receptor Clustering and Organization of Microtubules at the Postsynaptic Machinery. International Journal of Molecular Sciences. 2021. 22. 17. 9387-9387

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MISC (83)：

YAMAZAKI Hiroyuki, HANAMURA Kenji, SEGAWA Banri, TSUKAHARA Narutoshi, MURAKAMI Akikazu, SHIRAO Tomoaki. Live cell imaging of endogenous drebrin using camelidae single-domain antibody. Journal of Physiological Sciences (Web). 2020. 70. Supplement 1
Hanamura, Kenji, Kamata, Yousuke, Yamazaki, Hiroyuki, Kojima, Nobuhiko, Shirao, Tomoaki. Isoform-dependent regulation of drebrin dynamics in dendritic spines. NEUROSCIENCE. 2018. 379. 67-76
Yamazaki H, Sasagawa Y, Yamamoto H, Bito H, Shirao T. CaMKIIβ is localized in dendritic spines as both drebrin-dependent and drebrin-independent pools. JOURNAL OF NEUROCHEMISTRY. 2018. 146. 2. 145-159
Hanamura, Kenji, Kamata, Yousuke, Yamazaki, Hiroyuki, Kojima, Nobuhiko, Shirao, Tomoaki. Isoform-dependent regulation of drebrin dynamics in dendritic spines. NEUROSCIENCE. 2018. 379. 67-76
Yamazaki H, Sasagawa Y, Yamamoto H, Bito H, Shirao T. CaMKIIβ is localized in dendritic spines as both drebrin-dependent and drebrin-independent pools. JOURNAL OF NEUROCHEMISTRY. 2018. 146. 2. 145-159

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Patents (2)：

シナプス成熟障害モデル動物
樹状突起スパイン移行配列

Books (1)：

オックスフォード生理学原書4版
丸善出版 2016

Lectures and oral presentations (104)：

Drebrin functions as a scaffold for Ca2+/calmodulin-dependent protein kinase II in the core region of dendritic spines
(The 13th International Society of Radiation Neurobiology Conference 2024)
ドレブリン結合タンパク質の同定と機能解析
(樹状突起スパインの形成・維持・可塑性 2020)
ドレブリンによるシナプスのCaMKIIβの制御機能
(第一回ドレブリン研究会 2019)
シナプス形成におけるドレブリン結合タンパク質Spikarの役割
(第一回ドレブリン研究会 2019)
Super-resolution analysis of the interaction between drebrin and CaMKIIbeta in dendritic spines
(第60回日本神経化学会大会 2017)

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Education (3)：

1997 - 2001 Gunma University
1995 - 1997 Gunma University Graduate School, Division of Medical Sciences
1991 - 1995 Gunma University

Professional career (1)：

PhD (Gunma University)

Work history (8)：

2024/04 - 現在 Gunma Prefectural College of Health Sciences Professor
2021/04 - 2023/03 Gunma University of Health and Welfare Faculty of Social Welfare
2020/04 - 2021/03 群馬大学大学院医学系研究科薬理学講座助教
2008/04 - 2020/03 Gunma University
2007/04 - 2008/03 群馬大学大学院医学系研究科高次細胞機能学助教

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Committee career (3)：

日本神経化学会一般会員
日本神経科学会一般会員
国際放射線神経生物学会一般会員

Association Membership(s) (3)：

日本神経化学会 , 日本神経科学会 , 日本生理学会

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