Tsukano Chihiro

ツカノチヒロ | Tsukano Chihiro

Affiliation and department：
Job title： Assistant Professor,Assistant Professor

Research field (5)： Bioorganic chemistry , Pharmaceuticals - chemistry and drug development , Molecular biochemistry , Synthetic organic chemistry , Biochemistry

Research keywords (3)： Organic Chemistry , Natural Product Synthesis , Synthetic Chemistry

Research theme for competitive and other funds (11)：

2021 - 2024 機能性食品由来・未開拓新奇トリテルペノイドの全合成
2021 - 2023 大環状天然物の立体配座制御による高選択的な抗HIVシーズの開発
2017 - 2022 Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seeds
2017 - 2021 Total synthesis of natural products with unique and complex structures based on transformation of multi-substituted cyclopropanes
2018 - 2020 新規中分子医薬品シード創製を指向した脂肪酸を持つリポヌクレオシド系天然物の全合成

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Papers (74)：

Chihiro Tsukano, Ayumi Uchino, Kazuhiro Irie. Synthesis and Applications of Symmetric Amino Acid Derivatives. Organic & Biomolecular Chemistry, in press. 2023. 22. 3. 411-428
Jumpei Maki, Yusuke Hanaki, Ryo C Yanagita, Masayuki Kikumori, Anastasiia Kovba, Ayaka Washizaki, Chihiro Tsukano, Hirofumi Akari, Kazuhiro Irie. Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analogue of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation. Bioscience, Biotechnology, and Biochemistry. 2023. 87. 12. 1453-1461
Hidetaka Kuroiwa, Soichiro Suzuki, Kazuhiro Irie, Chihiro Tsukano. Total Synthesis and Structure Revision of (+)-Lancilactone C. Journal of the American Chemical Society. 2023. 145. 27. 14587-14591
Ryotaro Yagita, Kazuhiro Irie, Chihiro Tsukano. Toward the Total Synthesis of Schinortriterpenoids: Construction of the all-cis-substituted cyclopropane unit. Synlett. 2023
Katsutoshi Nishino, Kenta Someya, Chihiro Tsukano, Toshio Ishikawa, Masaya Nagao. Synthesis of 8β-hydroxy-9(11),13-abietadien-12-one from (+)-dehydroabietylamine and its AhR ligand activity. Results in Chemistry. 2023. 5

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MISC (219)：

Saori KITA, Kazuhiro IRIE, Chihiro TSUKANO. Synthetic Studies on the Right and Left-Hand Fragments of Epoxyboetirane A, a Lathyrane-Type Diterpene. 2024. 2024
Ayumi UCHINO, Chihiro TSUKANO, Kazuhiro IRIE. Synthetic study on the C3-symmetric tris-amino acid linker for the trimer models of amyloid β peptides. 2024. 2024
塚野千尋. アロタケタール類の単純化アナログの設計、立体異性体の系統的合成とPKC結合活性. 日本薬学会年会要旨集 144th. 2024. 2024
塚野千尋. アロタケタール類の単純化アナログの設計、立体異性体の系統的合成とPKC結合活性. 日本農芸化学会大会講演要旨集(Web). 2024. 2024
Chihiro Tsukano, Hidetaka Kuroiwa, Soichiro Suzuki, Kazuhiro Irie. Total Synthesis and Structure Revision of (+)-Lancilactone C. IKCOC-15. 2023

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Patents (2)：

アルツハイマー病予防薬
ポリ環状エーテル化合物とギムノシン-Aの合成方法

Books (4)：

Asymmetric Dearomatization Reactions
Wiley-VCH 2016 ISBN:9783527338511
多環性アルカロイドからの新規抗癌剤シード化合物創製、遺伝子医学MOOK20, ナノバイオ技術と最新創薬応用研究p66-71
メディカルドゥ 2012
(+)-Gymnocin-A
有機化学合成協会編(共著),化学同人,2009,p.85-88. 2009
巨大ポリエーテル天然物・ギムノシン-Aの全合成, 天然物全合成の最新動向
シーエムシー出版, 2009, p228-243. 2009

Education (4)：

2003 - 2006 Tohoku University Graduate School of Life Sciences Department of Biomolecular Sciences
2001 - 2003 The University of Tokyo Graduate School of Science Department of Chemistry
1999 - 2001 The University of Tokyo Faculty of Science Department of Chemistry
1997 - 1999 The University of Tokyo College of Arts and Sciences

Professional career (1)：

Life Sciences (Tohoku University)

Work history (7)：

2024/04 - 現在 Kyoto University Graduate School of Agriculture Division of Food Science and Biotechnology Professor
2019/04 - 2024/03 Kyoto University Graduate School of Agriculture Division of Food Science and Biotechnology Assistant Professor,Assistant Professor
2014/04 - 2019/03 Kyoto University Graduate School of Pharmaceutical Sciences Division of Physical and Organic Chemistry Lecturer
2009/06 - 2014/03 Kyoto University Graduate School of Pharmaceutical Sciences Division of Physical and Organic Chemistry Assistant Professor
2008/07 - 2009/05 Tohoku University Graduate School of Science Department of Chemistry Assistant Professor

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Awards (8)：

2022/07 - Bulletin of the Chemical Society of Japan BCSJ Award Article
2017/12 - Chemist Award BCA 2017
2017/11 - Thieme Thieme Chemistry Journals Award
2016/10 - Asian Core Program/ Advanced Research Network Lectureship Award
2016/03 - 日本薬学会奨励賞

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Association Membership(s) (5)：

The Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA) , The Parmaceutical Society of Japan , American Chemical Society , The Society of Synthetic Organic Chemistry, Japan , The Chemical Society of Japan

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