Kanegae Yumi

Research field (2)： Medical biochemistry , Virology

Research keywords (2)： Virology , Gene therapy

Research theme for competitive and other funds (11)：

2020 - 2023 Study of genome editing therapy for Sly disease based on different genome editing mechanisms
2011 - 2013 Improvement of helper-dependent adenovirus vector not only increasing gene expression but also cell/tissue specificity
2006 - 2007 Basic research on gene therapy by pulmonary epithelial cell growth factor on acute and chronic lung injury
2004 - 2005 Development of novel method for the construction of viral vectors using the site-specific recombinase
2000 - 2004 がん治療をめざしたアデノウイルスベクターを用いた発現制御法の開発

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Papers (23)：

Kazuyoshi Ohta, Masahiko Ito, Takeshi Chida, Kenji Nakashima, Satoshi Sakai, Yumi Kanegae, Hideya Kawasaki, Takuya Aoshima, Shuji Takabayashi, Hirotaka Takahashi, et al. Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation. PLoS pathogens. 2023. 19. 8. e1011591
Sayaka Nagamoto, Miyuki Agawa, Emi Tsuchitani, Kazunori Akimoto, Saki Kondo Matsushima, Yumi Kanegae. Short term but highly efficient Cas9 expression mediated by excisional system using adenovirus vector and Cre. Scientific reports. 2021. 11. 1. 24369-24369
Manabu Yamasaki, Norie Matsuda, Kazuaki Matoba, Saki Kondo, Yumi Kanegae, Izumu Saito, Akio Nomoto. Acetophenone 4-nitrophenylhydrazone inhibits Hepatitis B virus replication by modulating capsid assembly. Virus research. 2021. 306. 198565-198565
Yokoyama-Mashima S, Yogosawa S, Kanegae Y, Hirooka S, Yoshida S, Horiuchi T, Ohashi T, Yanaga K, Saruta M, Oikawa T, et al. Forced expression of DYRK2 exerts anti-tumor effects via apoptotic induction in liver cancer. Cancer letters. 2019. 451. 100-109
Saito T, Kuma A, Sugiura Y, Ichimura Y, Obata M, Okuda S, Lee HC, Ikeda K, Kanegae Y, Saito I, et al. Autophagy regulates lipid metabolism through selective turnover of NCoR1. Nature communications. 2019. 10. 1. 1567-1567

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MISC (41)：

A. Maekawa, Y. Kanegae. The novel elimination system of HBV DNA using adenovirus vector expressing Cas9 and guide RNAs. HUMAN GENE THERAPY. 2017. 28. 12. A65-A65
Y. Kanegae, A. Maekawa, Z. Pei, M. Suzuki, S. Kondo, I. Saito. Dual-safe adenovirus vector lacking virus-associated RNA genes enhanced shRNA activity. HUMAN GENE THERAPY. 2013. 24. 12. A79-A79
A. Maekawa, Z. Pei, M. Suzuki, S. Kondo, I. Saito, Y. Kanegae. Very efficient production of adenovirus vector lacking genes of virus-associated RNAs that disturb cellular RNAi machinery: safer alternative to current vector. HUMAN GENE THERAPY. 2013. 24. 12. A78-A79
S. Kondo, A. Maekawa, M. Suzuki, Y. Kanegae, I. Saito. First-generation adenovirus vector expresses viral-associated (VA) RNAs that disturb cellular gene expressions. HUMAN GENE THERAPY. 2013. 24. 12. A79-A79
裴崢, 史国利, 近藤小貴, 伊藤昌彦, 鐘ケ江裕美, 鈴木哲朗, 斎藤泉. VA RNA欠失型アデノウイルスベクターを用いたC型肝炎治療法の開発. 日本ウイルス学会学術集会プログラム・抄録集. 2012. 60th. 287

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Patents (2)：

Books (1)：

Education (4)：

- 1984 Kitasato University
- 1984 Kitasato University Graduate School, Division of Pharmaceutical Sciences
- 1982 Kitasato University School of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences
- 1982 Kitasato University Faculty of Pharmaceutical Science

Professional career (2)：

Work history (8)：

2019 - 2022/12 Jikei University School of Medicine Core Reserarch Facilities Professor
2016 - 2019 Jikei University School of Medicine Core Research Facilities for Basic Science Associate Professor
2001 - 2016 The University of Tokyo The Institute of Medical Science
1993 - 2001 東京大学医科学研究所遺伝子解析施設助手
1996 - 1998 米国The Salk Institute留学(Dr. Inder Verma)

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Committee career (1)：

Association Membership(s) (4)：

日本癌学会 , 日本遺伝子治療学会 , 日本分子生物学会 , 日本ウイルス学会

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