MURAKAMI Yuko

Affiliation and department：
Other affiliations (1)：

Juntendo University Faculty of Medicine

Research field (3)： Pharmaceuticals - health and biochemistry , Other , Pathobiochemistry

Research keywords (4)：合成致死 , DNA損傷修復 , がん , 細胞周期

Research theme for competitive and other funds (9)：

2021 - 2024 合成致死表現型を利用した腫瘍増殖機構の解析
2018 - 2021 Analysis of molecular mechanisms of cell proliferation in BAP1-mutated cancer using synthetic lethal phenotypes
2016 - 2019 Development of novel molecular diagnostic and therapeutic tools based on genomic information of malignant mesothelioma
2015 - 2019 Analysis of the Growth Mechanism of BAP1-Mutated Cancer Focused on DNA Damage Repair Factors
2013 - 2016 Identification of genes which shows synthetic lethality in malignant mesothelioma cells and application of them in clinics

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Papers (38)：

Koya Suzuki, Masaki Tange, Ryota Yamagishi, Hiroyuki Hanada, Satomi Mukai, Tatsuhiro Sato, Takeshi Tanaka, Tomohiro Akashi, Kenji Kadomatsu, Tohru Maeda, et al. SMG6 regulates DNA damage and cell survival in Hippo pathway kinase LATS2-inactivated malignant mesothelioma. Cell Death Discovery. 2022. 8. 1. 446-446
Yuuta Fujikawa, Masaya Mori, Minami Tsukada, Seiya Miyahara, Honoka Sato-Fukushima, Eita Watanabe, Yuko Murakami-Tonami, Hideshi Inoue. Pi-class Glutathione S-transferase (GSTP1)-selective fluorescent probes for multicolour imaging with various cancer-associated enzymes. ChemBioChem. 2022
Kodai Watanabe, Yuuta Fujikawa, Yuko Murakami-Tonami, Masaya Mori, Megumi Sakata, Hideshi Inoue. Design and synthesis of versatile GSTP1-specific fluorogenic substrates for the highly sensitive detection of GSTP1 activity in living cells. Talanta. 2022. 251. 123796-123796
Hong Nhung Nguyen, Suzuki Koya, Kimura Yasuaki, Hirokawa Takatsugu, Murakami-Tonami Yuko, Abe Hiroshi. SYNTHESIS AND BIOLOGICAL EVALUATION OF NMDI14 DERIVATIVES AS ANTI-MESOTHELIOMA AGENTS. Heterocycles. 2020. 100. 2. 253-266
Yuko Shishido, Fumiaki Tomoike, Keiko Kuwata, Haruka Fujikawa, Yoshitaka Sekido, Yuko Murakami-Tonami, Tomoshi Kameda, Naoko Abe, Yasuaki Kimura, Satoshi Shuto, et al. A Covalent Inhibitor for Glutathione S-Transferase Pi (GSTP1-1 ) in Human Cells. Chembiochem : a European journal of chemical biology. 2019. 20. 7. 900-905

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MISC (22)：

Shishido Yuko, Tomoike Fumiaki, Kimura Yasuaki, Kuwata Keiko, Yano Takato, Fukui Kenji, Fujikawa Haruka, Sekido Yoshitaka, Murakami-Tonami Yuko, Kameda Tomoshi, et al. Development of glutathione S-transferase (GST) covalent inhibitor. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2018. 255. .
宍戸裕子, 藤川遥加, 友池史明, 木村康明, 桑田啓子, 村上優子, 福井健二, 関戸好孝, 矢野貴人, 周東智, et al. グルタチオン-S-トランスフェラーゼを標的とした共有結合性阻害剤の開発. 生命科学系学会合同年次大会. 2017. 2017年度. [3P-0205]
村上優子, 渡並, 天野美希, 小木曽杏奈, 清成信一, 紅朋浩, 金田典雄, 門松健治, 村上浩士, 関戸好孝. 悪性中皮腫におけるBAP1遺伝子変異に対する合成致死遺伝子の網羅的探索. 生命科学系学会合同年次大会. 2017. 2017年度. [3AT26-05(3P
藤川遥加, 宍戸裕子, 村上優子, 関戸好孝, 阿部洋. グルタチオンS-トランスフェラーゼのプローブ開発. 日本癌学会総会記事. 2017. 76回. P-2323
宍戸裕子, 藤川遥加, 木村康明, 友池史明, 桑田啓子, 矢野貴人, 福井健二, 関戸好孝, 村上優子, 周東智, et al. 共有結合型グルタチオンS-転移酵素阻害剤の創薬研究. 日本薬学会年会要旨集. 2017. 137年会. 2. 68-68

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Education (3)：

2001 - 2005 Nagoya City University Graduate School of Medical Sciences
1995 - 2001 Nagoya City University
1990 - 1994 Hokkaido University Faculty of Pharmaceutical Sciences Department of Pharmacy

Professional career (1)：

医学博士

Work history (6)：

2019/09 - 現在 Tokyo University of Technology School of Bioscience and Biotechnology
2017/11 - 2019/08 Juntendo University Graduate School of Medicine
2012/10 - 2017/10 Aichi Cancer Center, Research Institute
2009/01 - 2012/09 Nagoya University Graduate School of Medicine, Graduate School of Medicine Others COE Designated Assistant Professor
2007/12 - 2008/12 Kyoto University Graduate School of Biostudies

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Association Membership(s) (7)：

THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER , THE JAPANESE CANCER ASSOCIATION , 分子生物学会 , 日本生化学会 , The molecular biology society of Japan , The Japanese biochemical society , 日本薬学会

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